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Research Article

Metabolic profile of chiral cobalt oxide nanoparticles in vitro and in vivo

Si Li1,2, Liwei Xu1,2, Meiru Lu1,2, Maozhong Sun1,2, Liguang Xu1,2, Changlong Hao1,2( ), Xiaoling Wu1,2( ), Chuanlai Xu1,2( ), Hua Kuang1,2
International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi 214122, China
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
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Abstract

In this study, we investigated the in vivo behaviors of chiral cobalt oxide nanoparticles (Co3O4 NPs) stabilized with D- or L-cysteine (denoted D- or L-NPs, respectively), as representative chiral metal oxide NPs. Chiral Co3O4 NPs exerted no observable cytotoxicity within the tested dose range. Both D-NPs and L-NPs were internalized by dendritic cells through caveola-dependent endocytosis, and L-NPs entered the cells faster than D-NPs. Significantly, a metabolic analysis indicated that chiral L-NPs had the same effect on the level of bile acids in the liver as D-NPs, which is attributed to the almost equal amount of farnesoid X receptor (FXR) induced by the chiral NPs. This study suggests that low chiroptical activity nanomaterials would not affect the metabolism and kinetics under physiological conditions even if there is some difference in their transport.

Keywords

chiral metal oxideendocytosisbile acidmetabolism

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Nano Research
Volume 14 Issue 7,
July 2021
Pages 2451-2455
DOI: 10.1007/s12274-020-3250-6
Cite this article:
Li S, Xu L, Lu M, et al. Metabolic profile of chiral cobalt oxide nanoparticles in vitro and in vivo. Nano Research, 2021, 14(7): 2451-2455. https://doi.org/10.1007/s12274-020-3250-6
Topics:
MetabolismMetal nanoparticlesMetalsMolecular biology

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Received: 21 October 2020
Revised: 13 November 2020
Accepted: 16 November 2020
Published: 05 July 2021
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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