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Research Article

Photo-triggered nucleus targeting for cancer drug delivery

Yafei Li1,2, Wen Lv2, Lang Wang3, Yaming Zhang1,2, Lipeng Yang4, Tianyi Wang1,2, Linyong Zhu4, Yufeng Wang3, Weiping Wang1,2()
Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong, China
Department of Chemistry, The University of Hong Kong, Hong Kong, China
School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200030, China
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Abstract

Here, we report a strategy to deliver drug nanoparticles into cells with nucleus-targeting ability under a spatiotemporal control. The nanoparticles were constructed through self-assembly of photoresponsive prodrugs and free drugs. By incorporating a nucleus localization sequence in the system, drug nanoparticles could be delivered into nuclei upon visible light irradiation. The drug nanoparticles showed high drug loading capacity and specific nucleus-targeting ability, which efficiently killed cancer cells. This self-assembly strategy could be applied to other hydrophobic drugs and targeting ligands for photo-controlled organelle-targeted drug delivery.

Keywords

phototargetingdePEGylationnucleus targetingcoumarinphotoresponsive prodrugs

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12274_2020_3264_MOESM1_ESM.pdf (3.1 MB)

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Nano Research
Volume 14 Issue 8,
August 2021
Pages 2630-2636
DOI: 10.1007/s12274-020-3264-0
Cite this article:
Li Y, Lv W, Wang L, et al. Photo-triggered nucleus targeting for cancer drug delivery. Nano Research, 2021, 14(8): 2630-2636. https://doi.org/10.1007/s12274-020-3264-0
Topics:
Cell proliferation Controlled drug deliveryDiseasesNanoparticlesSelf assembly
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