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Research Article

Near-infrared light-controllable bufalin delivery from a black phosphorus-hybrid supramolecular hydrogel for synergistic photothermal-chemo tumor therapy

Jiaqi He1,§, Guoqin Chen1,§, Peng Zhao2( ), Caiwen Ou3( )
Cardiology Department of Panyu Central Hospital Guangzhou University of Chinese MedicineGuangzhou 510006 China
Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences, Southern Medical UniversityGuangzhou 510515 China
Guangdong Provincial Key Laboratory of Shock and Microcirculation Zhujiang Hospital of Southern Medical University, Southern Medical UniversityGuangzhou 510280 China

§Jiaqi He and Guoqin Chen contributed equally to this work.

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Graphical Abstract

Abstract

Bufalin is efficacious in treating various tumors, however, the clinical application of which is restricted by the myocardial toxicity. Developing a smart synergetic delivery system is widely considered as a promising therapeutic strategy. To address this issue, a black phosphorus hybrid polypeptides hydrogel was designed to highly load bufalin, and achieved near-infrared (NIR)-controllable drug release with synergistic photothermal-chemo therapeutic effect. Black phosphorus nanosheets (BPNSs) and bufalin were co-loaded in temperature-sensitive supramolecular hydrogel to receive smart hybridization (BP-bufalin@SH). With NIR irradiation (1 W·cm-2), BP-bufalin@SH exhibited a rapid and large temperature increase and released bufalin via light-controllable manner, with which the side effects of bufalin were greatly decreased. Combined with photothermal-chemo therapeutic effect, BP-bufalin@SH could collapse the mitochondrial transmembrane potential resulting in the irreversible apoptosis of tumor cells, and realize a highly efficient in vivo tumor elimination with good biosafety and biocompatibility. This work provides a new hydrogel platform for controlling bufalin release, and thus further promotes the practical application on antitumor therapy.

Keywords

photothermal-chemo synergic therapybufalinblack phosphorus nanosheetssupramolecular hydrogel

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Nano Research
Volume 14 Issue 11,
November 2021
Pages 3988-3998
DOI: 10.1007/s12274-021-3325-z
Cite this article:
He J, Chen G, Zhao P, et al. Near-infrared light-controllable bufalin delivery from a black phosphorus-hybrid supramolecular hydrogel for synergistic photothermal-chemo tumor therapy. Nano Research, 2021, 14(11): 3988-3998. https://doi.org/10.1007/s12274-021-3325-z
Topics:
BiocompatibilityCell death Drug productsInfrared devices NanosheetsPhosphorusTargeted drug deliveryTumors

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Received: 21 November 2020
Revised: 05 January 2021
Accepted: 11 January 2021
Published: 05 February 2021
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021
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