AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Nano Research Article
Article Link
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Research Article

Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery

Zhongyin Chen1,§, Tao Liao1,§, Lihui Wan1, Ying Kuang2, Chang Liu1, Junlin Duan1, Xiangyu Xu1, Ziqiang Xu1( ), Bingbing Jiang1, Cao Li1( )
Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry Hubei Key Laboratory of Polymer Materials Hubei University Wuhan 430062 China
Glyn O. Philips Hydrocolloid Research Centre at HUT Hubei University of Technology Wuhan 430068 China

§ Zhongyin Chen and Tao Liao contributed equally to this work.

Show Author Information
An erratum to this article is available online at:
https://doi.org/10.1007/s12274-021-3765-5

Graphical Abstract

Abstract

Due to better penetrating abilities of near-infrared (NIR) light and lower autofluorescence of biological tissue at NIR region, the combination of NIR fluorescent imaging with therapeutic abilities has gradually emerged as a promising strategy for cancer therapy. Herein, tumor microenvironment (TME) sensitive nanocarriers based on doxorubicin hydrochloride (DOX), NIR emitting carbon dots (C-dots), hollow mesoporous silica nanoparticles (HMSN) and anionic polymer citraconic anhydride-modified polylysine (PLL(cit)) are fabricated for imaging guided drug delivery. The NIR emitting C-dots were conjugated onto the surface of HMSN via disulfide bonds which can be reduced by intracellular glutathione (GSH) and result in the release of DOX into cells. And then the PLL(cit) was grafted on the surface of the nanocarriers to endow the nanocarriers with charge convertible property in mildly acidic TME (pH = 6.50) which results in prolonged blood circulation time and enhanced cellular internalization. The in vitro and in vivo experiments confirmed that the dual pH/GSH responsive features of nanocarriers can eliminate the tumor tissues effectively and elicit much slighter side effects. Moreover, since the fluorescence of C-dots can be recovered after the reduction of disulfide bonds and selectively accumulation of nanocarriers around tumor tissue, the DOX@HMSN-SS-C-dots-PLL(cit) can be served as a promising NIR fluorescence probe for targeted imaging of tumor tissue. As a kind of multifunctional nanocarrier with NIR fluorescent imaging and therapeutic functions, the theranostic nanocarriers hold great potential for tumor therapy and in vivo imaging of tumor tissue.

Keywords

charge-reversalhollow mesoporous silica nanoparticlesnear-infrared emissive carbon dotsdual-stimuli responsive

Electronic Supplementary Material

Download File(s)
12274_2021_3624_MOESM1_ESM.pdf (3.7 MB)

References

1

Liu, H. W.; Chen, L. L.; Xu, C. Y.; Li, Z.; Zhang, H. Y.; Zhang, X. B.; Tan, W. H. Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging. Chem. Soc. Rev. 2018, 47, 7140–7180.
Crossref Google Scholar
2

Mou, C. Y.; Yang, Y.; Bai, Y.; Yuan, P.; Wang, Y. W.; Zhang, L. K. Hyaluronic acid and polydopamine functionalized phase change nanoparticles for ultrasound imaging-guided photothermal-chemotherapy. J. Mater. Chem. B 2019, 7, 1246–1257.
Crossref Google Scholar
3

Deng, X. R.; Liang, S.; Cai, X. C.; Huang, S. S.; Cheng, Z. Y.; Shi, Y. S.; Pang, M. L.; Ma, P. A.; Lin, J. Yolk-shell structured au nanostar@metal-organic framework for synergistic chemo-photothermal therapy in the second near-infrared window. Nano Lett. 2019, 19, 6772–6780.
Crossref Google Scholar
4

Wei, R. X.; Gong, X. Q.; Lin, H. Y.; Zhang, K.; Li, A.; Liu, K.; Shan, H.; Chen, X. Y.; Gao, J. H. Versatile octapod-shaped hollow porous manganese(ii) oxide nanoplatform for real-time visualization of cargo delivery. Nano Lett. 2019, 19, 5394–5402.
Crossref Google Scholar
5

Sun, Q. H.; Zhou, Z. X.; Qiu, N. S.; Shen, Y. Q. Rational design of cancer nanomedicine: Nanoproperty integration and synchronization. Adv. Mater. 2017, 29, 1606628.
Crossref Google Scholar
6

Wang, M. L.; Yang, Q. M.; Li, M.; Zou, H. M.; Wang, Z. G.; Ran, H. T.; Zheng, Y. Y.; Jian, J.; Zhou, Y.; Luo, Y. D. et al. Multifunctional nanoparticles for multimodal imaging-guided low-intensity focused ultrasound/immunosynergistic retinoblastoma therapy. ACS Appl. Mater. Interfaces 2020, 12, 5642–5657.
Crossref Google Scholar
7

Liu, Z. W.; Song, F. L.; Shi, W. B.; Gurzadyan, G.; Yin, H. Y.; Song, B.; Liang, R.; Peng, X. J. Nitroreductase-activatable theranostic molecules with high pdt efficiency under mild hypoxia based on a TADF fluorescein derivative. ACS Appl. Mater. Interfaces 2019, 11, 15426–15435.
Crossref Google Scholar
8

Miranda, D.; Carter, K.; Luo, D. D.; Shao, S.; Geng, J. M.; Li, C. N.; Chitgupi, U.; Turowski, S. G.; Li, N. S.; Atilla-Gokcumen, G. E. et al. Multifunctional liposomes for image-guided intratumoral chemo- phototherapy. Adv. Healthc. Mater. 2017, 6, 1700253.
Crossref Google Scholar
9

Gong, N. Q.; Ma, X. W.; Ye, X. X.; Zhou, Q. F.; Chen, X. A.; Tan, X. L.; Yao, S. K.; Huo, S. D.; Zhang, T. B.; Chen, S. Z. et al. Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment. Nat. Nanotechnol. 2019, 14, 379–387.
Crossref Google Scholar
10

Chen, T.; Su, L. C.; Ge, X. G.; Zhang, W. M.; Li, Q. Q.; Zhang, X.; Ye, J. M.; Lin, L. S.; Song, J. B.; Yang, H. H. Dual activated NIR-II fluorescence and photoacoustic imaging-guided cancer chemo- radiotherapy using hybrid plasmonic-fluorescent assemblies. Nano Res. 2020, 13, 3268–3277.
Crossref Google Scholar
11

Zhang, L.; Yang, Z.; Ren, J. H.; Ba, L.; He, W. S.; Wong, C. Y. Multifunctional oxygen-enriching nano-theranostics for cancer-specific magnetic resonance imaging and enhanced photodynamic/photothermal therapy. Nano Res. 2020, 13, 1389–1398.
Crossref Google Scholar
12

Xu, L.; Zhao, Y. L.; Owusu, K. A.; Zhuang, Z. C.; Liu, Q.; Wang, Z. Y.; Li, Z. H.; Mai, L. Q. Recent advances in nanowire-biosystem interfaces: From chemical conversion, energy production to electrophysiology. Chem 2018, 4, 1538–1559.
Crossref Google Scholar
13

Liu, C. H.; Zheng, J.; Deng, L.; Ma, C.; Li, J. S.; Li, Y. H.; Yang, S.; Yang, J. F.; Wang, J.; Yang, R. H. Targeted intracellular controlled drug delivery and tumor therapy through in situ forming ag nanogates on mesoporous silica nanocontainers. ACS Appl. Mater. Interfaces 2015, 7, 11930–11938.
Crossref Google Scholar
14

Zhang, L.; Ji, X. Y.; Su, Y. Y.; Zhai, X.; Xu, H.; Song, B.; Jiang, A. R.; Guo, D. X.; He, Y. Fluorescent silicon nanoparticles-based nanotheranostic agents for rapid diagnosis and treatment of bacteria-induced keratitis. Nano Res. 2021, 14, 52–58.
Crossref Google Scholar
15

Lu, H. W.; Xu, Y. J.; Qiao, R. R.; Lu, Z. W.; Wang, P.; Zhang, X. D.; Chen, A.; Zou, L. M.; Wang, Z. L. A novel clustered spio nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy. Nano Res. 2020, 13, 2216–2225.
Crossref Google Scholar
16

Tang, W.; Fan, W. P.; Wang, Z. T.; Zhang, W. Z.; Zhou, S. Y.; Liu, Y. J.; Yang, Z.; Shao, E.; Zhang, G. F.; Jacobson, O. et al. Acidity/ reducibility dual-responsive hollow mesoporous organosilica nano­platforms for tumor-specific self-assembly and synergistic therapy. ACS Nano 2018, 12, 12269–12283.
Crossref Google Scholar
17

Blum, N. T.; Yildirim, A.; Gyorkos, C.; Shi, D.; Cai, A.; Chattaraj, R.; Goodwin, A. P. Temperature-responsive hydrophobic silica nanoparticle ultrasound contrast agents directed by phospholipid phase behavior. ACS Appl. Mater. Interfaces 2019, 11, 15233–15240.
Crossref Google Scholar
18

Chen, W.; Cheng, C. A.; Cosco, E. D.; Ramakrishnan, S.; Lingg, J. G. P.; Bruns, O. T.; Zink, J. I.; Sletten, E. M. Shortwave infrared imaging with J-aggregates stabilized in hollow mesoporous silica nanoparticles. J. Am. Chem. Soc. 2019, 141, 12475–12480.
Crossref Google Scholar
19

Gu, T. X.; Chen, T.; Cheng, L.; Li, X.; Han, G. R.; Liu, Z. Mesoporous silica decorated with platinum nanoparticles for drug delivery and synergistic electrodynamic-chemotherapy. Nano Res. 2020, 13, 2209–2215.
Crossref Google Scholar
20

Chen, F.; Hong, H.; Goel, S.; Graves, S. A.; Orbay, H.; Ehlerding, E. B.; Shi, S. X.; Theuer, C. P.; Nickles, R. J.; Cai, W. B. In vivo tumor vasculature targeting of CuS@MSN based theranostic nanomedicine. ACS Nano 2015, 9, 3926–3934.
Crossref Google Scholar
21

Yu, L. D.; Chen, Y.; Wu, M. Y.; Cai, X. J.; Yao, H. L.; Zhang, L. L.; Chen, H. R.; Shi, J. L. "Manganese extraction" strategy enables tumor-sensitive biodegradability and theranostics of nanoparticles. J. Am. Chem. Soc. 2016, 138, 9881–9894.
Crossref Google Scholar
22

Lu, N.; Fan, W. P.; Yi, X.; Wang, S.; Wang, Z. T.; Tian, R.; Jacobson, O.; Liu, Y. J.; Yung, B. C.; Zhang, G. F. et al. Biodegradable hollow mesoporous organosilica nanotheranostics for mild hyperthermia- induced bubble-enhanced oxygen-sensitized radiotherapy. ACS Nano 2018, 12, 1580–1591.
Crossref Google Scholar
23

Sun, C. X.; Li, B. H.; Zhao, M. Y.; Wang, S. F.; Lei, Z. H.; Lu, L. F.; Zhang, H. X.; Feng, L. S.; Dou, C. R.; Yin, D. R. et al. J-aggregates of cyanine dye for NIR-II in vivo dynamic vascular imaging beyond 1, 500 nm. J. Am. Chem. Soc. 2019, 141, 19221–19225.
Crossref Google Scholar
24

Xu, G.; Yan, Q. L.; Lv, X. G.; Zhu, Y.; Xin, K.; Shi, B.; Wang, R. C.; Chen, J.; Gao, W.; Shi, P. et al. Imaging of colorectal cancers using activatable nanoprobes with second near-infrared window emission. Angew. Chem. , Int. Ed. 2018, 57, 3626–3630.
Crossref Google Scholar
25

Liu, L.; Wang, S. F.; Zhao, B. Z.; Pei, P.; Fan, Y.; Li, X. M.; Zhang, F. Er3+ sensitized 1, 530 nm to 1, 180 nm second near-infrared window upconversion nanocrystals for in vivo biosensing. Angew. Chem. , Int. Ed. 2018, 57, 7518–7522.
Crossref Google Scholar
26

Peng, X. Y.; Wang, R.; Wang, T. J.; Yang, W. N.; Wang, H.; Gu, W.; Ye, L. Carbon dots/prussian blue satellite/core nanocomposites for optical imaging and photothermal therapy. ACS Appl. Mater. Interfaces 2018, 10, 1084–1092.
Crossref Google Scholar
27

Lyu, Y.; He, S. S.; Li, J. C.; Jiang, Y. Y.; Sun, H.; Miao, Y. S.; Pu, K. Y. A photolabile semiconducting polymer nanotransducer for near-infrared regulation of CRISPR/Cas9 gene editing. Angew. Chem. , Int. Ed. 2019, 58, 18197–18201.
Crossref Google Scholar
28

Li, J. C.; Duan, H. W.; Pu, K. Y. Nanotransducers for near-infrared photoregulation in biomedicine. Adv. Mater. 2019, 31, 1901607.
Crossref Google Scholar
29

He, K.; Zhu, J. Y.; Gong, L. S.; Tan, Y.; Chen, H. R.; Liang, H. R.; Huang, B. H.; Liu, J. B. In situ self-assembly of near-infrared- emitting gold nanoparticles into body-clearable 1d nanostructures with rapid lysosome escape and fast cellular excretion. Nano Res. 2021, 14, 1087–1094.
Crossref Google Scholar
30

Pan, L. L.; Sun, S.; Zhang, L.; Jiang, K.; Lin, H. W. Near-infrared emissive carbon dots for two-photon fluorescence bioimaging. Nanoscale 2016, 8, 17350–17356.
Crossref Google Scholar
31

Zhou, B.; Guo, Z. X.; Lin, Z. X.; Zhang, L. Z.; Jiang, B. P.; Shen, X. C. Recent insights into near-infrared light-responsive carbon dots for bioimaging and cancer phototherapy. Inorg. Chem. Front. 2019, 6, 1116–1128.
Crossref Google Scholar
32

Xu, Z. Q.; Liu, Y. The behavior of carbonized polymer dots at the nano-bio interface and their luminescent mechanism: A physical chemistry perspective. Chin. J. Chem. 2021, 39, 265–273.
Crossref Google Scholar
33
Sun, Z. H.; Yan, F. Y.; Xu, J.; Zhang, H.; Chen, L. Solvent- controlled synthesis strategy of multicolor emission carbon dots and its applications in sensing and light-emitting devices. Nano Res., in press, https://doi.org/10.1007/s12274-021-3495-8.
Crossref
34

Chen, J. J.; Ding, J. X.; Wang, Y. C.; Cheng, J. J.; Ji, S. X.; Zhuang, X. L.; Chen, X. S. Sequentially responsive shell-stacked nanoparticles for deep penetration into solid tumors. Adv. Mater. 2017, 29, 1701170.
Crossref Google Scholar
35

Liu, J. J.; Liang, H. N.; Li, M. H.; Luo, Z.; Zhang, J. X.; Guo, X. M.; Cai, K. Y. Tumor acidity activating multifunctional nanoplatform for NIR-mediated multiple enhanced photodynamic and photothermal tumor therapy. Biomaterials 2018, 157, 107–124.
Crossref Google Scholar
36

Liu, Y. J.; Guo, X. Y.; Yang, S. H.; He, G. X.; Jin, H. B. Controllable preparation of uniform micron-sized barium-sulfate spheres. Cryst. Res. Technol. 2018, 53, 1700212.
Crossref Google Scholar
37

Wan, L. H.; Chen, Z. Y.; Deng, Y.; Liao, T.; Kuang, Y.; Liu, J.; Duan, J. L.; Xu, Z. Q.; Jiang, B. B.; Li, C. A novel intratumoral pH/redox-dual-responsive nanoplatform for cancer MR imaging and therapy. J. Colloid Interface Sci. 2020, 573, 263–277.
Crossref Google Scholar
38

Chen, Z. Y.; Wan, L. H.; Yuan, Y.; Kuang, Y.; Xu, X. Y.; Liao, T.; Liu, J.; Xu, Z. Q.; Jiang, B. B.; Li, C. pH/GSH-dual-sensitive hollow mesoporous silica nanoparticle-based drug delivery system for targeted cancer therapy. ACS Biomater. Sci. Eng. 2020, 6, 3375–3387.
Crossref Google Scholar
39

Xu, C.; Chen, F.; Valdovinos, H. F.; Jiang, D. W.; Goel, S.; Yu, B.; Sun, H. Y.; Barnhart, T. E.; Moon, J. J.; Cai, W. B. Bacteria-like mesoporous silica-coated gold nanorods for positron emission tomography and photoacoustic imaging-guided chemo-photothermal combined therapy. Biomaterials 2018, 165, 56–65.
Crossref Google Scholar
40

Chen, X.; Liu, Y. N.; Lin, A. G.; Huang, N.; Long, L. Q.; Gang, Y.; Liu, J. Folic acid-modified mesoporous silica nanoparticles with pH-responsiveness loaded with Amp for an enhanced effect against anti-drug-resistant bacteria by overcoming efflux pump systems. Biomater. Sci. 2018, 6, 1923–1935.
Crossref Google Scholar
41

Luo, Z.; Hu, Y.; Cai, K. Y.; Ding, X. W.; Zhang, Q.; Li, M. H.; Ma, X.; Zhang, B. L.; Zeng, Y. F.; Li, P. Z. et al. Intracellular redox-activated anticancer drug delivery by functionalized hollow mesoporous silica nanoreservoirs with tumor specificity. Biomaterials 2014, 35, 7951–7962.
Crossref Google Scholar
42

Sun, T. T.; Zheng, M.; Xie, Z. G.; Jing, X. B. Supramolecular hybrids of carbon dots with doxorubicin: Synthesis, stability and cellular trafficking. Mater. Chem. Front. 2017, 1, 354–360.
Crossref Google Scholar
43

Hou, L.; Chen, D. D.; Wang, R. T.; Wang, R. B.; Zhang, H. J.; Zhang, Z. Z.; Nie, Z. H.; Lu, S. Y. Transformable honeycomb-like nanoassemblies of carbon dots for regulated multisite delivery and enhanced antitumor chemoimmunotherapy. Angew. Chem., Int. Ed. 2020, 60, 6581–6592.
Crossref Google Scholar
44

Zhang, S. Y.; Xiao, C. Q.; He, H.; Xu, Z. Q.; Wang, B. B.; Chen, X. Q.; Li, C.; Jiang, B. B.; Liu, Y. The adsorption behaviour of carbon nanodots modulated by cellular membrane potential. Environ. Sci. Nano 2020, 7, 880–890.
Crossref Google Scholar
45

Ma, J.; Kang, K.; Zhang, Y. J.; Yi, Q. Y.; Gu, Z. W. Detachable polyzwitterion-coated ternary nanoparticles based on peptide dendritic carbon dots for efficient drug delivery in cancer therapy. ACS Appl. Mater. Interfaces 2018, 10, 43923–43935.
Crossref Google Scholar
46

Dong, Y. M.; Du, P. C.; Liu, P. Absolutely "off-on" fluorescent CD- based nanotheranostics for tumor intracellular real-time imaging and ph-triggered DOX delivery. J. Mater. Chem. B 2020, 8, 8002–8009.
Crossref Google Scholar
47

Gao, N.; Yang, W.; Nie, H. L.; Gong, Y. Q.; Jing, J.; Gao, L. J.; Zhang, X. L. Turn-on theranostic fluorescent nanoprobe by electrostatic self-assembly of carbon dots with doxorubicin for targeted cancer cell imaging, in vivo hyaluronidase analysis, and targeted drug delivery. Biosens. Bioelectron. 2017, 96, 300–307.
Crossref Google Scholar
48

Du, J. Z.; Li, H. J.; Wang, J. Tumor-acidity-cleavable maleic acid amide (tacmaa): A powerful tool for designing smart nanoparticles to overcome delivery barriers in cancer nanomedicine. Acc. Chem. Res. 2018, 51, 2848–2856.
Crossref Google Scholar
49

Feng, T.; Ai, X. Z.; An, G. H.; Yang, P. P.; Zhao, Y. L. Charge- convertible carbon dots for imaging-guided drug delivery with enhanced in vivo cancer therapeutic efficiency. ACS Nano 2016, 10, 4410–4420.
Crossref Google Scholar
50

Liu, J.; Chang, B. C.; Li, Q. L.; Xu, L. M.; Liu, X. X.; Wang, G. B.; Wang, Z.; Wang, L. Redox-responsive dual drug delivery nanosystem suppresses cancer repopulation by abrogating doxorubicin-promoted cancer stemness, metastasis, and drug resistance. Adv. Sci. 2019, 6, 1801987.
Crossref Google Scholar
51

Zhang, M.; Liu, J.; Kuang, Y.; Li, Q. L.; Chen, H. Y.; Ye, H. F.; Guo, L.; Xu, Y. L.; Chen, X. Q.; Li, C. et al. "Stealthy" chitosan/mesoporous silica nanoparticle based complex system for tumor-triggered intracellular drug release. J. Mater. Chem. B 2016, 4, 3387–3397.
Crossref Google Scholar
52

He, T. F.; Zhang, C. Z.; Vedadghavami, A.; Mehta, S.; Clark, H. A.; Porter, R. M.; Bajpayee, A. G. Multi-arm avidin nano-construct for intra-cartilage delivery of small molecule drugs. J. Control. Release 2020, 318, 109–123.
Crossref Google Scholar
Nano Research
Volume 14 Issue 11,
November 2021
Pages 4264-4273
DOI: 10.1007/s12274-021-3624-4
Cite this article:
Chen Z, Liao T, Wan L, et al. Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery. Nano Research, 2021, 14(11): 4264-4273. https://doi.org/10.1007/s12274-021-3624-4
Topics:
Nanodots

753

Views

39

Crossref

38

Web of Science

36

Scopus

1

CSCD

Altmetrics
Received: 06 April 2021
Revised: 24 May 2021
Accepted: 26 May 2021
Published: 23 July 2021
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021
Return