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Research Article

Infrared nanoimaging of nanoscale sliding dislocation of collagen fibrils

Zhi Qiao1,2, Mengfei Xue3,4,5, Yongqian Zhao4,5, Yindong Huang2, Ming Zhang6, Chao Chang1,2( ), Jianing Chen4,5,7( )
Key Laboratory for Physical Electronics and Devices of the Ministry of Education, School of Electronic Science and Engineering, Xi'an Jiaotong University, Xi’an 710049, China
Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Beijing 100071, China
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China
Institute of Physics, Chinese Academy of Sciences and Beijing National Laboratory for Condensed Matter Physics, Beijing 100190, China
School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
Department of Neurobiology, Collaborative Innovation Center for Brain Science and Shaanxi Key Laboratory of Brain Disorders, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, China
Songshan Lake Materials Laboratory, Dongguan 523808, China
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Graphical Abstract

Abstract

Collagen, one of the major components in the mammalian connective tissues, plays an essential role in many vital physiological processes. Many common diseases, such as fibrosis, overuse injuries, and bone fracture, are associated with collagen arrangement defects. However, the underlying mechanism of collagen arrangement defects remains elusive. In this study, we applied infrared scattering-type scanning near-field optical microscopy to study collagen fibrils’ structural properties. Experimentally, we observed two types of collagen fibrils’ arrangement with different periodic characteristics. A crystal sliding model was employed to explain this observation qualitatively. Our results suggest that the collagen dislocation propagates in collagen fibrils, which may shed light on many collagen diseases’ pathogenesis. These findings help to understand the regulation mechanism of hierarchical biological structure.

Keywords

scattering near-field optical microscopycollagen fibrilsdislocationD periodicity

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Nano Research
Volume 15 Issue 3,
March 2022
Pages 2355-2361
DOI: 10.1007/s12274-021-3721-4
Cite this article:
Qiao Z, Xue M, Zhao Y, et al. Infrared nanoimaging of nanoscale sliding dislocation of collagen fibrils. Nano Research, 2022, 15(3): 2355-2361. https://doi.org/10.1007/s12274-021-3721-4
Topics:
Infrared imaging

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Received: 08 May 2021
Revised: 24 June 2021
Accepted: 28 June 2021
Published: 12 August 2021
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021
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