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Research Article

Natural product curcumin-based coordination nanoparticles for treating osteoarthritis via targeting Nrf2 and blocking NLRP3 inflammasome

Zhiqiang Zhou1,§, Fei Gong2,§(), Peng Zhang1,§, Xiaotong Wang3,§, Rui Zhang2, Wei Xia4, Xiang Gao1, Xiaozhong Zhou1(), Liang Cheng2()
Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China
Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China
Department of Hepatology and Gastroenterology, The Affiliated Infectious Hospital of Soochow University, Suzhou 215007, China
Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China

§ Zhiqiang Zhou, Fei Gong, Peng Zhang, and Xiaotong Wang contributed equally to this work.

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Graphical Abstract

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This scheme illustrates the natural product curcumin-based coordination nanoparticles (Fe-Cur NPs) for treating osteoarthritis via targeting nuclear factor-erythroid 2 related factor-2 (Nrf2) and blocking nod-like receptor protein-3 (NLRP3) inflammasome.

Abstract

Oxidative stress leads to chondrocyte apoptosis and extracellular matrix (ECM) degradation, thus contributing to the pathogenesis of osteoarthritis (OA). Herein, curcumin with remarkable antioxidant and anti-inflammatory activities has been employed as an organic ligand to coordinate ferric ions for enhancing the water-solubility and biocompatibility of natural product curcumin. The obtained iron-curcumin-based coordination nanoparticles (Fe-Cur NPs) exhibit great water-solubility and efficient reactive oxygen/nitrogen species (ROS/RNS) scavenging ability. In vitro chondrocyte evaluation experiments indicated that the intracellular ROS/RNS induced by interleukin 1β (IL-1β) could be efficiently scavenged by these Fe-Cur NPs and oxidative-stress-induced cell death could be preserved as well. In addition, post intra-articular (i.a.) injection into OA rat joints, Fe-Cur NPs could greatly inhibit OA progression via activating the nuclear factor-erythroid 2 related factor-2 (Nrf2) and inhibiting nod-like receptor protein-3 (NLRP3) inflammasome activation in primary rat chondrocytes, as well as decrease the production of matrix degrading proteases and other inflammatory mediators. The efficient antioxidation and anti-inflammation performance of Fe-Cur NPs endow them as a promising nanoplatform for treatment of various inflammatory diseases, and more detailed researches will be conducted in the future.

Keywords

iron-curcumin-based coordination nanoparticles (Fe-Cur NPs)reactive oxygen/nitrogen species (ROS/RNS) scavenging abilityosteoarthritisantioxidation and anti-inflammation performancesignaling pathway

Electronic Supplementary Material

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12274_2021_3864_MOESM1_ESM.pdf (557.9 KB)

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Nano Research
Volume 15 Issue 4,
April 2022
Pages 3338-3345
DOI: 10.1007/s12274-021-3864-3
Cite this article:
Zhou Z, Gong F, Zhang P, et al. Natural product curcumin-based coordination nanoparticles for treating osteoarthritis via targeting Nrf2 and blocking NLRP3 inflammasome. Nano Research, 2022, 15(4): 3338-3345. https://doi.org/10.1007/s12274-021-3864-3
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