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Research Article

Localized surface plasmon resonance improves transdermal photodynamic therapy of hypertrophic scars

Yunsheng Chen1, Zhixi Yu1, Xinxian Meng1, Hua Li1, Xiyang Sun2(), Dannong He3, Yixin Zhang1,3(), Zheng Zhang1()
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China
Hongqiao International Institute of Medicine, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200336, China
Shanghai National Engineering Research Center for Nanotechnology, Shanghai 200237, China
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Graphical Abstract

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5-Aminolevulinic acid (ALA) and Au nanotriangles (AuNTs) co-delivery nanoethosomes (A/A-ES) achieve the transdermal co-delivery of ALA and AuNTs, and enhance ALA excitation via localized surface plasmon resonance (LSPR) effect. This work provides an effective strategy to improve transdermal photodynamic therapy (PDT) efficacy through LSPR-enhanced reactive oxygen species (ROS) generation

Abstract

Photodynamic therapy (PDT) is an emerging therapeutic strategy for hypertrophic scars (HS), which is heavily dependent on reactive oxygen species (ROS) generation. However, the unsatisfactory delivery and excitation of 5-aminolevulinic acid (ALA, a commercial photosensitizer in dermatology) result in an insufficient ROS generation, and thus limit the clinical application of PDT treating HS (HS-PDT). Consequently, sophisticated transdermal co-delivery nanoethosomes (named A/A-ES) with ALA and Au nanotriangles (AuNTs) in cores are prepared via an in-situ seed-mediated growth method, and then applied to improve HS-PDT through localized surface plasmon resonance (LSPR)-enhanced ROS generation. A/A-ES display a satisfactory performance in co-delivery in HS tissue with sufficient protoporphyrin IX production and LSPR effect in cytoplasm, which is beneficial for ALA excitation as well as ROS generation. In vitro/vivo studies reveal that A/A-ES significantly improve HS-PDT in promoting to fibroblast apoptosis and collagen remodeling through LSPR-enhanced ROS generation. Therefore, this study provides a feasible strategy that integrates transdermal delivery and LSPR to enable the beneficial effects of HS-PDT through boosting the delivery and excitation of ALA.

Keywords

hypertrophic scarslocalized surface plasmon resonancenanoethosomesphotodynamic therapyreactive oxygen speciestransdermal co-delivery

Electronic Supplementary Material

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12274_2021_4067_MOESM1_ESM.pdf (652.6 KB)

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Nano Research
Volume 15 Issue 5,
May 2022
Pages 4258-4265
DOI: 10.1007/s12274-021-4067-7
Cite this article:
Chen Y, Yu Z, Meng X, et al. Localized surface plasmon resonance improves transdermal photodynamic therapy of hypertrophic scars. Nano Research, 2022, 15(5): 4258-4265. https://doi.org/10.1007/s12274-021-4067-7
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