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Research Article

NIR-II photothermal therapy for effective tumor eradication enhanced by heterogeneous nanorods with dual catalytic activities

Linghua Zhang1,§, Wenjie Wang1,§, Meng Ou1, Xiaoxiao Huang2, Yu Ma1, Jiayue Tang1, Ting Hou1, Sheng Zhang1, Li Yin1, Huan Chen3, Yanglong Hou2( ), Ya Ding1( )
Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
Beijing Key Laboratory for Magnetoelectric Materials and Devices, Beijing Innovation Center for Engineering Science and Advanced Technology, School of Materials Science and Engineering, Peking University, Beijing 100871, China
Department of Biochemistry, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China

§ Linghua Zhang and Wenjie Wang contributed equally to this work.

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Graphical Abstract

We successfully design and synthesize bovine serum albumin-coated heterogeneous Pd-Au nanorods to solve the current bottleneck problems of photothermal thermal therapy, and completely eliminate tumors in animal models without toxic side effects by collaborating with heterogeneous nanorod-mediated bioorthogonal catalytic therapy and chemodynamic therapy.

Abstract

Rational design and exploitation of nanomaterials with superior treatment properties for suitable indications is a way out to relieve cost constraint of therapy and solve the unsatisfactory efficacy for cancer patients. In this work, we propose a greatly facile approach to produce heterogeneous Pd-Au nanorods (Pd-Au NRs) that solve the current bottleneck problems of photothermal thermal therapy (PTT) as well as completely eliminate tumors in animal models without toxic side effects. Depositing Pd clusters on both tips of Au NRs offers Pd-Au NRs three novel functions, i.e., the extension of the absorption into NIR-II region, the activation of prodrug of 5-fluorouracil (5-Fu) via the bioorthogonal reaction, and the peroxidase-mimic activity to produce ·OH. The heterogeneous nanorods showed a high and stable photothermal conversion efficiency (52.07%) in a safer NIR-II irradiation region (1,064 nm), which not only eliminate most of tumor cells at only one dose of the irradiation for 5 min but also improve the in situ conversion of 5-fluoro-1-propargyluracil and H2O2 into active 5-Fu and ·OH to eradicate residual tumors for inhibiting tumor metastasis. This dual catalytic activity-synergistic mechanism of PTT demonstrates the importance of material design in solving current bottleneck problem of tumor therapy.

Keywords

heterogeneous nanorodsPd-Auphotothermal therapybioorthogonal catalysisperoxidase-mimic activity

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References

1

Lu, Y.; Aimetti, A. A.; Langer, R.; Gu, Z. Bioresponsive materials. Nat. Rev. Mater. 2017, 2, 16075.
Crossref Google Scholar
2

Wang, J.; Li, Y. Y.; Nie, G. J. Multifunctional biomolecule nanostructures for cancer therapy. Nat. Rev. Mater. 2021, 6, 766–783.
Crossref Google Scholar
3

Sung, H.; Ferlay, J.; Siegel, R. L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: Cancer J. Clin. 2021, 71, 209–249.
Crossref Google Scholar
4

Fan, W. P.; Yung, B.; Huang, P.; Chen, X. Y. Nanotechnology for multimodal synergistic cancer therapy. Chem. Rev. 2017, 117, 13566–13638.
Crossref Google Scholar
5

Wei, H.; Wang, E. K. Nanomaterials with enzyme-like characteristics (nanozymes): Next-generation artificial enzymes. Chem. Soc. Rev. 2013, 42, 6060–6093.
Crossref Google Scholar
6

Liu, Y. J.; Bhattarai, P.; Dai, Z. F.; Chen, X. Y. Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer. Chem. Soc. Rev. 2019, 48, 2053–2108.
Crossref Google Scholar
7

Sun, H. T.; Zhang, Q.; Li, J. C.; Peng, S. J.; Wang, X. L.; Cai, R. Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy. Nano Today 2021, 37, 101073.
Crossref Google Scholar
8

Huang, X. J.; Zhang, W. L.; Guan, G. Q.; Song, G. S.; Zou, R. J.; Hu, J. Q. Design and functionalization of the NIR-responsive photothermal semiconductor nanomaterials for cancer theranostics. Acc. Chem. Res. 2017, 50, 2529–2538.
Crossref Google Scholar
9

Abbas, M.; Zou, Q. L.; Li, S. K.; Yan, X. H. Self-assembled peptide- and protein-based nanomaterials for antitumor photodynamic and photothermal therapy. Adv. Mater. 2017, 29, 1605021.
Crossref Google Scholar
10

Liu, S.; Pan, X. T.; Liu, H. Y. Two-dimensional nanomaterials for photothermal therapy. Angew. Chem., Int. Ed. 2020, 59, 5890–5900.
Crossref Google Scholar
11

Yang, J.; Yao, M. H.; Jin, R. M.; Zhao, D. H.; Zhao, Y. D.; Liu, B. Polypeptide-engineered hydrogel coated gold nanorods for targeted drug delivery and chemo-photothermal therapy. ACS Biomater. Sci. Eng. 2017, 3, 2391–2398.
Crossref Google Scholar
12

Zhang, Z. J.; Wang, L. M.; Wang, J.; Jiang, X. M.; Li, X. H.; Hu, Z. J.; Ji, Y. L.; Wu, X. C.; Chen, C. Y. Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment. Adv. Mater. 2012, 24, 1418–1423.
Crossref Google Scholar
13

Shen, S.; Tang, H. Y.; Zhang, X. T.; Ren, J. F.; Pang, Z. Q.; Wang, D. G.; Gao, H. L.; Qian, Y.; Jiang, X. G.; Yang, W. L. Targeting mesoporous silica-encapsulated gold nanorods for chemo-photothermal therapy with near-infrared radiation. Biomaterials 2013, 34, 3150–3158.
Crossref Google Scholar
14

Ye, X. C.; Zheng, C.; Chen, J.; Gao, Y. Z.; Murray, C. B. Using binary surfactant mixtures to simultaneously improve the dimensional tunability and monodispersity in the seeded growth of gold nanorods. Nano Lett. 2013, 13, 765–771.
Crossref Google Scholar
15

Chen, Y. S.; Zhao, Y.; Yoon, S. J.; Gambhir, S. S.; Emelianov, S. Miniature gold nanorods for photoacoustic molecular imaging in the second near-infrared optical window. Nat. Nanotechnol. 2019, 14, 465–472.
Crossref Google Scholar
16

Sugiura, T.; Matsuki, D.; Okajima, J.; Komiya, A.; Mori, S.; Maruyama, S.; Kodama, T. Photothermal therapy of tumors in lymph nodes using gold nanorods and near-infrared laser light with controlled surface cooling. Nano Res. 2015, 8, 3842–3852.
Crossref Google Scholar
17

Terentyuk, G.; Panfilova, E.; Khanadeev, V.; Chumakov, D.; Genina, E.; Bashkatov, A.; Tuchin, V.; Bucharskaya, A.; Maslyakova. G.; Khlebtsov, N. et al. Gold nanorods with a hematoporphyrin-loaded silica shell for dual-modality photodynamic and photothermal treatment of tumors in vivo. Nano Res. 2014, 7, 325–337.
Crossref Google Scholar
18

Zeng, J. Y.; Zhang, M. K.; Peng, M. Y.; Gong, D.; Zhang, X. Z. Porphyrinic metal–organic frameworks coated gold nanorods as a versatile nanoplatform for combined photodynamic/photothermal/chemotherapy of tumor. Adv. Funct. Mater. 2018, 28, 1705451.
Crossref Google Scholar
19

Nam, J.; Son, S.; Ochyl, L. J.; Kuai, R.; Schwendeman, A.; Moon, J. J. Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer. Nat. Commun. 2018, 9, 1074.
Crossref Google Scholar
20

Deng, X. R.; Liang, S.; Cai, X. C.; Huang, S. S.; Cheng, Z. Y.; Shi, Y. S.; Pang, M. L.; Ma, P. A.; Lin, J. Yolk–shell structured Au nanostar@metal–organic framework for synergistic chemo-photothermal therapy in the second near-infrared window. Nano Lett. 2019, 19, 6772–6780.
Crossref Google Scholar
21

Rautio, J.; Meanwell, N. A.; Di, L.; Hageman, M. J. The expanding role of prodrugs in contemporary drug design and development. Nat. Rev. Drug. Discov. 2018, 17, 559–587.
Crossref Google Scholar
22

Dong, S. M.; Dong, Y. S.; Jia, T.; Liu, S. K.; Liu, J.; Yang, D.; He, F.; Gai, S. L.; Yang, P. P.; Lin, J. GSH-depleted nanozymes with hyperthermia-enhanced dual enzyme-mimic activities for tumor nanocatalytic therapy. Adv. Mater. 2020, 32, 2002439.
Crossref Google Scholar
23

Dong, Y. S.; Tu, Y. L.; Wang, K. W.; Xu, C. F.; Yuan, Y. Y.; Wang, J. A general strategy for macrotheranostic prodrug activation: Synergy between the acidic tumor microenvironment and bioorthogonal chemistry. Angew. Chem., Int. Ed. 2020, 59, 7168–7172.
Crossref Google Scholar
24

Wang, W. J.; Zhang, X. Z.; Huang, R.; Hirschbiegel, C. M.; Wang, H. S.; Ding, Y.; Rotello, V. M. In situ activation of therapeutics through bioorthogonal catalysis. Adv. Drug Deliv. Rev. 2021, 176, 113893.
Crossref Google Scholar
25

Yao, Q. X.; Lin, F.; Fan, X. Y.; Wang, Y. P.; Liu, Y.; Liu, Z. F.; Jiang, X. Y.; Chen, P. R.; Gao, Y. Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems. Nat. Commun. 2018, 9, 5032.
Crossref Google Scholar
26

Du, Z.; Liu, C.; Song, H. L.; Scott, P.; Liu, Z. Q.; Ren, J. S.; Qu, X. G. Neutrophil-membrane-directed bioorthogonal synthesis of inflammation-targeting chiral drugs. Chem. 2020, 6, 2060–2072.
Crossref Google Scholar
27

Chang, M. Y.; Hou, Z. Y.; Wang, M.; Yang, C. Z.; Wang, R. F.; Li, F.; Liu, D. L.; Peng, T. L.; Li, C. X.; Lin, J. Single-atom Pd nanozyme for ferroptosis-boosted mild-temperature photothermal therapy. Angew Chem., Int. Ed. 2021, 60, 12971–12979.
Crossref Google Scholar
28

Hu, Y. H.; Lv, T.; Ma, Y.; Xu, J. J.; Zhang, Y. H.; Hou, Y. L.; Huang, Z. J.; Ding, Y. Nanoscale coordination polymers for synergistic NO and chemodynamic therapy of liver cancer. Nano Lett. 2019, 19, 2731–2738.
Crossref Google Scholar
29

Xiang, S. J.; Fan, Z. X.; Ye, Z. C.; Zhu, T. B.; Shi, D.; Ye, S. F.; Hou, Z. Q.; Chen, X. L. Endogenous Fe2+-activated ROS nanoamplifier for esterase-responsive and photoacoustic imaging-monitored therapeutic improvement. Nano Res. 2022, 15, 907–918.
Crossref Google Scholar
30

Sancho-Albero, M.; Rubio-Ruiz, B.; Pérez-López, A. M.; Sebastián, V.; Martín-Duque, P.; Arruebo, M.; Santamaría, J.; Unciti-Broceta, A. Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis. Nat. Catal. 2019, 2, 864–872.
Crossref Google Scholar
31

Su, G. X.; Jiang, H. Q.; Zhu, H. Y.; Lv, J. J.; Yang, G. H.; Yan, B.; Zhu, J. J. Controlled deposition of palladium nanodendrites on the tips of gold nanorods and their enhanced catalytic activity. Nanoscale 2017, 9, 12494–12502.
Crossref Google Scholar
32

Petreni, A.; Bonardi, A.; Lomelino, C.; Osman, S. M.; ALOthman, Z. A.; Eldehna, W. M.; El-Haggar, R.; McKenna, R.; Nocentini, A.; Supuran, C. T. Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells. Eur. J. Med. Chem. 2020, 190, 112112.
Crossref Google Scholar
33

Wang, X.; Ma, Y. C.; Sheng, X.; Wang, Y. C.; Xu, H. X. Ultrathin polypyrrole nanosheets via space-confined synthesis for efficient photothermal therapy in the second near-infrared window. Nano Lett. 2018, 18, 2217–2225.
Crossref Google Scholar
34

Mugaka, B. P.; Zhang, S.; Li, R. Q.; Ma, Y.; Wang, B.; Hong, J.; Hu, Y. H.; Ding, Y.; Xia, X. H. One-pot preparation of peptide-doped metal–amino acid framework for general encapsulation and targeted delivery. ACS Appl. Mater. Interfaces 2021, 13, 11195–11204.
Crossref Google Scholar
35

Liu, A. Y.; Wang, H. S.; Hou, X. S.; Ma, Y.; Yang, G. J.; Hou, Y. L.; Ding, Y. Combinatory antitumor therapy by cascade targeting of a single drug. Acta Pharm. Sin. B. 2020, 10, 667–679.
Crossref Google Scholar
36

Cui, T.; Ma, Y.; Yang, J. Y.; Liu, S.; Wang, Z. Z.; Zhang, F. F.; Wang, J.; Cai, T.; Dong, L.; Hong, J. et al. Protein corona-guided tumor targeting therapy via the surface modulation of low molecular weight PEG. Nanoscale 2021, 13, 5883–5891.
Crossref Google Scholar
37

Ge, C. C.; Fang, G.; Shen, X. M.; Chong, Y.; Wamer, W. G.; Gao, X. F.; Chai, Z. F.; Chen, C. Y.; Yin, J. J. Facet energy versus enzyme-like activities: The unexpected protection of palladium nanocrystals against oxidative damage. ACS Nano 2016, 10, 10436–10445.
Crossref Google Scholar
38

Nikoobakht, B.; El-Sayed, M. A. Preparation and growth mechanism of gold nanorods (NRs) using seed-mediated growth method. Chem. Mater. 2003, 15, 1957–1962.
Crossref Google Scholar
39

Liu, M. Z.; Guyot-Sionnest, P. Mechanism of silver(I)-assisted growth of gold nanorods and bipyramids. J. Phys. Chem. B 2005, 109, 22192–22200.
Crossref Google Scholar
40

Sau, T. K.; Murphy, C. J. Seeded high yield synthesis of short Au nanorods in aqueous solution. Langmuir 2004, 20, 6414–6420.
Crossref Google Scholar
41

Ye, J. M.; Li, Z.; Fu, Q. R.; Li, Q. Q.; Zhang, X.; Su, L. C.; Yang, H. H.; Song, J. B. Quantitative photoacoustic diagnosis and precise treatment of inflammation in vivo using activatable theranostic nanoprobe. Adv. Funct. Mater. 2020, 30, 2001771.
Crossref Google Scholar
42

Roper, D. K.; Ahn, W.; Hoepfner, M. Microscale heat transfer transduced by surface Plasmon resonant gold nanoparticles. J. Phys. Chem. C 2007, 111, 3636–3641.
Crossref Google Scholar
43

Du, Y.; Yang, C.; Li, F. Y.; Liao, H. W.; Chen, Z.; Lin, P. H.; Wang, N.; Zhou, Y.; Lee, J. Y.; Ding, Q. et al. Core–shell–satellite nanomaces as remotely controlled self-fueling Fenton reagents for imaging-guided triple-negative breast cancer-specific therapy. Small 2020, 16, 2002537.
Crossref Google Scholar
44

Ma, N. N.; Jiang, Y. W.; Zhang, X. D.; Wu, H.; Myers, J. N.; Liu, P. D.; Jin, H. Z.; Gu, N.; He, N. Y.; Wu, F. G. et al. Enhanced radiosensitization of gold nanospikes via hyperthermia in combined cancer radiation and photothermal therapy. ACS Appl. Mater. Interfaces 2016, 8, 28480–28494.
Crossref Google Scholar
45

Wang, Z.; Liu, B.; Sun, Q. Q.; Feng, L. L.; He, F.; Yang, P. P.; Gai, S. L.; Quan, Z. W.; Lin, J. Upconverted metal–organic framework janus architecture for near-infrared and ultrasound co-enhanced high performance tumor therapy. ACS Nano 2021, 15, 12342–12357.
Crossref Google Scholar
46

Wei, J. P.; Chen, X. L.; Shi, S. G.; Mo, S. G.; Zheng, N. F. An investigation of the mimetic enzyme activity of two-dimensional Pd-based nanostructures. Nanoscale 2015, 7, 19018–19026.
Crossref Google Scholar
47

Speyer, J. L.; Collins, J. M.; Dedrick, R. L.; Brennan, M. F.; Buckpitt, A. R.; Londer, H.; DeVita, V. T. Jr.; Myers, C. E. Phase I and pharmacological studies of 5-fluorouracil administered intraperitoneally. Cancer Res. 1980, 40, 567–572.
Google Scholar
Nano Research
Volume 15 Issue 5,
May 2022
Pages 4310-4319
DOI: 10.1007/s12274-022-4096-x
Cite this article:
Zhang L, Wang W, Ou M, et al. NIR-II photothermal therapy for effective tumor eradication enhanced by heterogeneous nanorods with dual catalytic activities. Nano Research, 2022, 15(5): 4310-4319. https://doi.org/10.1007/s12274-022-4096-x
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Received: 10 November 2021
Revised: 20 December 2021
Accepted: 22 December 2021
Published: 24 January 2022
© Tsinghua University Press 2022
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