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Research Article

Dual-modality magnetic resonance/optical imaging-guided sonodynamic therapy of pancreatic cancer with metal–organic nanosonosensitizer

Yingli Chen1,2,§, Bo Yin3,§, Zhuang Liu2, Han Wang4, Zi Fu4, Xiuru Ji4, Wei Tang2( ), Dalong Ni4( ), Weijun Peng2( )
Shanghai Institution of Medical Imaging, Fudan University, Shanghai 200032, China
Department of Radiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China
Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

§ Yingli Chen and Bo Yin contributed equally to this work.

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Graphical Abstract

A novel metal–organic sonosensitizers of Gd-PPNs was synthesized through two steps with magnetic resonance imaging (MRI) and fluorescence imaging (FLI) both available for guiding sonodynamic therapy (SDT) of pancreatic cancer.

Abstract

Sonodynamic therapy (SDT) has been more attractive to carry out oncology treatments in recent years. However, imaging-guided sonodynamic therapeutic nanomedicine is still a shortage in SDT development. In this work, we designed and fabricated an organic SDT system based on combination of 1,2,4,5-tetrakis(4-carboxyphenyl)-porphyrin (TCPP) and gadolinium(III) (Gd3+) creatively (Gd-PPNs). Gd3+ was traditionally used to be T1-weighted magnetic resonance imaging (MRI) contrast agent and TCPP was initiatively a fluorescence imaging organic media. Therefore, these new designed nanoparticles have immense potential to integrate MRI and FLI to visualize the Gd-PPNs accumulating and keeping in tumor for a long time, which could be applied for guidance of SDT on tumors in clinical practice. Importantly, excellent SDT efficiency under imaging guidance was verified both in vitro and in vivo in this work. Our findings suggested that Gd-PPNs, as innovative imaging and therapy combinational nanomedicines, were successfully synthesized and were proved to possess excellent imaging-guided sonodynamic therapeutic efficacy. Moreover, this new designed sonosensitizer had great biocompatibility to avoid unnecessary biotoxicity. Overall, this strategy shed light on the MRI/FLI-guidance and successfully induced pancreatic tumor growth inhibition by sonodynamic therapy.

Keywords

pancreatic tumorsonodynamic therapytheranosticsmagnetic resonance imaging

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Nano Research
Volume 15 Issue 7,
July 2022
Pages 6340-6347
DOI: 10.1007/s12274-022-4284-8
Cite this article:
Chen Y, Yin B, Liu Z, et al. Dual-modality magnetic resonance/optical imaging-guided sonodynamic therapy of pancreatic cancer with metal–organic nanosonosensitizer. Nano Research, 2022, 15(7): 6340-6347. https://doi.org/10.1007/s12274-022-4284-8
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Nano biology

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Received: 09 January 2022
Revised: 28 February 2022
Accepted: 01 March 2022
Published: 04 April 2022
© Tsinghua University Press 2022
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