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Research Article

Oxygen vacancy-engineered BaTiO3 nanoparticles for synergistic cancer photothermal, photodynamic, and catalytic therapy

Yiming Ding1,2,§, Zhuo Wang2,§, Zeyu Zhang1,2, Yunchao Zhao1,2, Shangyu Yang3,4, Yalong Zhang1,2, Shuncheng Yao2,3, Shaobo Wang1,2, Tian Huang1,2, Yang Zhang3,4( ), Linlin Li1,2,5( )
School of Chemistry and Chemical Engineering, Center on Nanoenergy Research, School of Physical Science & Technology, Guangxi University, Nanning 530004, China
Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China
Key Laboratory of Semiconductor Material Sciences, Beijing Key Laboratory of Low Dimensional Semiconductor Materials and Devices, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China
College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China
School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China

§ Yiming Ding and Zhuo Wang contributed equally to this work.

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Graphical Abstract

A synergetic enhanced therapeutic nanoplatform integrating photothermal therapy (PTT), photodynamic therapy (PDT), and catalytic therapy is constructed based on BaTiO3 nanoparticles via defect engineering.

Abstract

With the rapid development of photo-responsive nanomaterials, photo-triggered therapeutic strategies such as photothermal therapy (PTT) and photodynamic therapy (PDT) have been new alternatives to current cancer therapeutic methods. Herein, we have fabricated oxygen vacancy-engineered BaTiO3 (BTO-Ov) nanoparticles (NPs) for near-infrared (NIR) light-triggered PTT, PDT, and catalytic therapy cooperatively for significantly improving cancer therapy. Compared to pristine BaTiO3 nanoparticles, BTO-Ov has stronger NIR light absorption and narrower band gap structure, which results in superior photothermal conversion and superoxide radical generation capabilities through PTT and PDT. Meanwhile, due to the existence of Ti3+, BTO-Ov also exhibits peroxidase (POD)-like activity to produce hydroxyl radical under tumor environment, which can be further improved under 808 nm light irradiation. Both in vitro and in vivo results demonstrate that such a multifunctional therapeutic nanoplatform can achieve a high therapeutic efficacy triggered by a single NIR light irradiation. The defect engineering strategy can be used as a general approach to fabricate multifunctional cancer therapeutic nanoplatform.

Keywords

oxygen vacancyBaTiO3photothermal therapyphotodynamic therapyperoxidase

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Nano Research
Volume 15 Issue 8,
August 2022
Pages 7304-7312
DOI: 10.1007/s12274-022-4336-0
Cite this article:
Ding Y, Wang Z, Zhang Z, et al. Oxygen vacancy-engineered BaTiO3 nanoparticles for synergistic cancer photothermal, photodynamic, and catalytic therapy. Nano Research, 2022, 15(8): 7304-7312. https://doi.org/10.1007/s12274-022-4336-0
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Received: 25 February 2022
Revised: 16 March 2022
Accepted: 16 March 2022
Published: 10 May 2022
© Tsinghua University Press 2022
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