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Research Article

Hyaluronic acid-based dual-responsive nanomicelles mediated mutually synergistic photothermal and molecular targeting therapies

Liangliang Cai1,§, Ronghua Ni1,§, Xiaofei Ma1,§, Rongrong Huang1, Zhiyuan Tang1, Jinqiu Xu1, Yong Han2( ), Yuehua Guo3( ), Zhifeng Gu4( )
Department of Pharmacy, Affiliated Hospital of Nantong University, Nantong 226001, China
Department of Radiation Oncology, Affiliated Hospital of Nantong University, Nantong 226001, China
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China
Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong 226001, China

§ Liangliang Cai, Ronghua Ni, and Xiaofei Ma contributed equally to this work.

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Graphical Abstract

A novel dual-responsive nanomicelles (CA-NMs) were conveniently constructed through self-assembly and the anticancer efficacy of CA-NMs was enhanced by mutually synergistic photothermal therapy/ molecularly targeted therapy (PTT/MTT), active targeting of hyaluronic acid (HA), and sufficient drug release.

Abstract

Precise clinical treatment of triple-negative breast cancer (TNBC) is an obstacle in clinic. Nanotechnology-assisted photothermal therapy (PTT) is a superior treatment modality for TNBC in terms of precision. However, thermoresistance arising from PTT and insufficient drug release from nanocarriers decrease the efficacy of PTT. AT13387 is a novel HSP90 inhibitor that can weaken thermoresistance and undergoing clinic II phase study, showing satisfactory antitumour activity through molecularly targeted therapy (MTT). Whereas, it has poor solubility. Hence hyaluronic acid and stearic acid were connected by hydrazone bonds and disulfide bonds, forming an amphipathic copolymer that could self-assembled into nanomicelles, followed by encapsulating Cypate and AT13387. These nanomicelles exhibited great features, including achieving mutually synergistic PTT/MTT for overcoming thermoresistance and promoting translocation of drugs, increasing the solubility of Cypate and AT13387, showing a pH/redox dual response that contributes to drug release, and having the ability of active targeting. Thus, the nanomicelles developed in this study may be a promising strategy for the precise treatment of TNBC.

Keywords

hyaluronic acidnanomicellesdual responsivephotothermal therapymolecular targeting therapy

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Nano Research
Volume 15 Issue 7,
July 2022
Pages 6361-6371
DOI: 10.1007/s12274-022-4368-5
Cite this article:
Cai L, Ni R, Ma X, et al. Hyaluronic acid-based dual-responsive nanomicelles mediated mutually synergistic photothermal and molecular targeting therapies. Nano Research, 2022, 15(7): 6361-6371. https://doi.org/10.1007/s12274-022-4368-5
Topics:
Drug therapy

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Received: 12 February 2022
Revised: 25 March 2022
Accepted: 28 March 2022
Published: 07 May 2022
© Tsinghua University Press 2022
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