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Research Article

Ultrathin covalent organic framework nanosheet-based photoregulated metal-free oxidase-like nanozyme

Yongwu Peng1,4, Minchu Huang1, Liangjun Chen1, Chengtao Gong1, Nanjun Li1, Ying Huang2( ), Changming Cheng3( )
College of Materials Science and Engineering and College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China
State Key Laboratory of Environment-friendly Energy Materials, Southwest University of Science and Technology, Mianyang 621010, China
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics (CAEP), Mianyang 612900, China
Jiangsu Province Engineering Research Center of Agricultural Breeding Pollution Control and Resource, Yancheng Teachers University, Yancheng 224007, China
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Graphical Abstract

By using flexible photoactive building units, ultrathin covalent organic framework nanosheets are designed as novel photoregulated metal-free oxidase-like nanozyme, which can effectively catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) under light irradiation in the presence of O2.

Abstract

The exploration of low-cost and metal-free nanozymes with oxidase-mimicking activity is highly desired due to their attractive properties and potential applications. However, it is still challenging and remains unexploited to fully realize oxidase-like nanozyme in the emerging covalent organic frameworks (COFs) due to their polymeric nature and weak photoelectric activity. We herein report the first example of the preparation and oxidase-mimicking activity of novel ultrathin two-dimensional (2D) COF (termed as TTPA-COF) nanosheets. The ultrathin TTPA-COF nanosheets with hexagonal layered structure are constructed from two flexible photoactive (diarylamino)benzene-based linkers, and exhibit remarkable catalytic activity toward the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) in the presence of O2 due to their large specific surface areas and abundant active sites. Moreover, it is worth noting that the nanozyme activity could be regulated by external light irradiation. Based on the oxidase-mimicking activity of TTPA-COF nanosheets, a green colorimetric sensor is proposed for the sensitive and selective determination of glutathione (GSH) in a wide linear range of 0.5–40 µM with a detection limit of 0.5 µM. This work reported here would open new avenues for the exploration of low-cost and high-efficiency nanozymes, as well as extend the application of 2D COF nanosheets in the fields of catalysis and sensing.

Keywords

covalent organic framework nanosheetsultrathinphotoregulatedmetal-freeoxidase mimics

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Nano Research
Volume 15 Issue 10,
October 2022
Pages 8783-8790
DOI: 10.1007/s12274-022-4541-x
Cite this article:
Peng Y, Huang M, Chen L, et al. Ultrathin covalent organic framework nanosheet-based photoregulated metal-free oxidase-like nanozyme. Nano Research, 2022, 15(10): 8783-8790. https://doi.org/10.1007/s12274-022-4541-x
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Received: 11 February 2022
Revised: 05 April 2022
Accepted: 16 May 2022
Published: 15 June 2022
© Tsinghua University Press 2022
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