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Research Article

NIR-II fluorescence/photoacoustic imaging of ovarian cancer and peritoneal metastasis

Siyu Lu1,2,§, Liru Xue1,§, Meng Yang3,§, Jingjing Wang2, Yang Li2, Yuxin Jiang3, Xuechuan Hong1,2,4, Mingfu Wu1( ), Yuling Xiao2,5( )
State Key Laboratory of Virology, Department Gynecology, Cancer Biology Research Center, Tongji Hospital; Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Department of Cardiology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China
College of Science, Research Center for Ecology, Laboratory of Extreme Environmental Biological Resources and Adaptive Evolution, Tibet University, Lhasa 850000, China
Shenzhen Institute of Wuhan University, Shenzhen 518057, China

§ Siyu Lu, Liru Xue, and Meng Yang contributed equally to this work.

Show Author Information

Graphical Abstract

H10@follicle-stimulating hormone (FSH) dots have been developed for near-infrared II (NIR-II, 1,000–1,700 nm) fluorescence/photoacoustic imaging of ovarian cancer and peritoneal metastasis.

Abstract

Ovarian cancer is a global problem, and is typically diagnosed in the middle or late stages, with a mysterious abdominal mass or atypical abdominal metastases due to the lack of specific initial diagnostic methods. Dual-modal near-infrared II (NIR-II, 1,000–1,700 nm) fluorescence/photoacoustic imaging has great potential in early ovarian cancer diagnosis and image-guided surgery due to its high sensitivity and deep penetration. Herein, we report a novel organic NIR-II dye (H10) with excellent aggregation-induced-emission (AIE) characteristics (I/I0 > 1.6) utilizing a selenadiazolo-[3,4-f]benzo[c][1,2,5]thiadiazole (ST)-based building block. Then, water-soluble and biocompatible H10@follicle-stimulating hormone (H10@FSH) dots with superior optical/photoacoustic properties and a tenfold increase in ovarian-specific targeting ability were synthesized. Finally, for the first time, in vivo dual-mode NIR-II fluorescent/photoacoustic (PA) imaging and image-guided surgery of patient-derived tumor xenograft (PDTX) and micro-metastatic abdominal ovarian cancer lesions were investigated. This novel strategy will establish a new method for early detection of ovarian cancer and significantly improve the prognosis of ovarian cancer patients.

Keywords

ovarian cancerperitoneal metastasisnear-infrared II (NIR-II, 1,000–1,700 nm) fluorescence/photoacoustic dual-modal imagingearly detection

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Nano Research
Volume 15 Issue 10,
October 2022
Pages 9183-9191
DOI: 10.1007/s12274-022-4592-z
Cite this article:
Lu S, Xue L, Yang M, et al. NIR-II fluorescence/photoacoustic imaging of ovarian cancer and peritoneal metastasis. Nano Research, 2022, 15(10): 9183-9191. https://doi.org/10.1007/s12274-022-4592-z
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Received: 14 March 2022
Revised: 24 May 2022
Accepted: 28 May 2022
Published: 26 July 2022
© Tsinghua University Press 2022
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