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Research Article

Ce and Se co-doped MBG/SA/HLC microgel bone powder for repairing tumor bone defects

Miaolin Fan1, Wan Liu2, Cuiying Fan3, Xiaoyan Zheng1, Junfeng Hui1( ), Chaoquan Hu4( ), Daidi Fan1,2( )
Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R & D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi’an 710069, China
Biotech. & Biomed. Research Institute, Northwest University, Xi’an 710069, China
Xi’an Giant Biogene Technology Co., Ltd., Xi’an 710069, China
Nanjing IPE Institute of Green Manufacturing Industry, Nanjing 211100, China
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Graphical Abstract

The schematic diagram exhibited the preparation of organic/inorganic composite microgel bone powders and their application in tumor inhibition and bone repair.

Abstract

The repair and treatment of tumor bone defects is a difficult problem to solve urgently in clinical medicine. After tumor resection, patients are not only faced with a large area of bone defect, but also may have the risk of tumor recurrence, which can easily cause huge physical and mental harm to patients. In this study, we successfully designed and constructed an organic/inorganic composite microgel bone powder (S-H-M3%Ce/3%Se) based on cerium (Ce) and selenium (Se) elements co-doped mesoporous bioactive glass (M3%Ce/3%Se), sodium alginate (SA), and recombinant human-like collagen (HLC). The obtained S-H-M3%Ce/3%Se could inhibit the growth of osteoma cells and promote the growth of normal cells, and effectively promote the repair of defect bone. The integration of the “treatment and repair” organic/inorganic composite microgel bone powder provided a new strategy for the treatment of cancerous bone defects.

Keywords

mesoporous bioactive glassfunctional elementsosteoma inhibitionbone repair

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Nano Research
Volume 16 Issue 1,
January 2023
Pages 746-756
DOI: 10.1007/s12274-022-4630-x
Cite this article:
Fan M, Liu W, Fan C, et al. Ce and Se co-doped MBG/SA/HLC microgel bone powder for repairing tumor bone defects. Nano Research, 2023, 16(1): 746-756. https://doi.org/10.1007/s12274-022-4630-x
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Received: 14 May 2022
Revised: 05 June 2022
Accepted: 05 June 2022
Published: 30 July 2022
© Tsinghua University Press 2022
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