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Research Article

A non-surgical suturing strategy for rapid cardiac hemostasis

Yuan Gao1,§, Jun Zhang1,§, Nan Cheng2,§, Zhong Liu1, Yuan-Bin Wu2, Qian-Qian Zhou3, Chen-Yan Li3, Miao Yu1, Seeram Ramakrishna4, Rong Wang2( ), Yun-Ze Long1,5( )
Collaborative Innovation Center for Nanomaterials & Devices, College of Physics, Qingdao University, Qingdao 266071, China
Department of Adult Cardiac Surgery, the Sixth Medical Center of PLA General Hospital, Beijing 100084, China
Institute of Health Service and Transfusion Medicine, Beijing 100850, China
Center for Nanofibers & Nanotechnology, Department of Mechanical Engineering, National University of Singapore, Singapore 117574, Singapore
State Key Laboratory of Bio-Fibers & Eco-Textiles, Qingdao 266071, China

§ Yuan Gao, Jun Zhang, and Nan Cheng contributed equally to this work.

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Graphical Abstract

Two-step hemostasis: A non-surgical suturing strategy for rapid cardiac hemostasis. A nanohemostatic fabric (CHP) was prepared by solution blow spinning (PLA/GEL) and air spraying (AHP), and cardiac hemostasis was rapidly accomplished in 4 min by combining the hemostatic fabric (CHP) with in-situ electrospinning of medical glue.

Abstract

As the central organ of the human body, once the heart is damaged, it will cause devastating damage to the circulation system of the whole body, often leading to rapid death. Currently, the only treatment option to stop bleeding in penetrating cardiac injuries is surgical suturing, which is extremely complex and risky. In addition, it is difficult to implement this kind of treatment in battlefields with poor medical conditions. Therefore, there is an urgent need to develop an effective cardiac hemostasis strategy. In this work, we propose a two-step hemostasis strategy that can effectively stop bleeding for penetrating heart injuries. That is, cardiac hemostatic plug (CHP) is made from the nanocomposite (polylactic acid/gelatin/absorbable hemostatic particles, PLA/GEL/AHP) with high biosafety, excellent hemostatic performance, and degradability which is used to block cardiac bleeding, and then wound surface is sealed by in-situ electrospun medical glue fibers (N-octyl-2-cyanoacrylate, interfacial toughness: 221 ± 23 J·m−2), thus completing cardiac hemostasis (porcine heart with 1 cm diameter penetrating wound). The hemostasis process is simple and quick (< 2 min). In addition, it is worth mentioning that we have also proposed a new composite method based on solution blow spinning that is suitable for doping various functional particles, and the PLA/GEL/AHP composite nanofiber membrane prepared by this method is also a promising hemostatic material.

Keywords

heartcardiac hemostasisnanocompositesolution blow spinningelectrospinning

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Nano Research
Volume 16 Issue 1,
January 2023
Pages 810-821
DOI: 10.1007/s12274-022-4691-x
Cite this article:
Gao Y, Zhang J, Cheng N, et al. A non-surgical suturing strategy for rapid cardiac hemostasis. Nano Research, 2023, 16(1): 810-821. https://doi.org/10.1007/s12274-022-4691-x
Topics:
Nano biology

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Received: 11 May 2022
Revised: 20 June 2022
Accepted: 21 June 2022
Published: 05 August 2022
© Tsinghua University Press 2022
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