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Research Article

Terbium-doped zinc oxide constructed dual-light-responsive nitric oxide-releasing platform for bacterial keratitis treatment

Yue Sun1, Wei Zhang1, Menghui Wang2, Huijie Liu2, Qun Li2, Jiazhe Luo2, Mengzhen Zhao2, Shichen Liu2, Xiaolei Wang1,2( )
School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330088, China
The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang 330088, China
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Graphical Abstract

Tb-doped ZnO constructed dual-light-responsive NO-releasing platform (CL-ZT@P@B) for the prevention and in situ treatment of bacterial keratitis (BK). The platform can release reactive oxygen species (ROS) and NO under the excitation of green light and 808 nm near-infrared (NIR), with the assistance of zinc ions to achieve efficient antibacterial and anti-inflammatory thereby treating bacterial keratitis.

Abstract

Bacterial keratitis (BK) is a principal factor contributing to corneal ulcers and ocular complications, and has become a significant killer of global vision health. Traditional antibiotic therapy has unsatisfactory therapeutic effect due to short residence time and low utilization rate of drug, and the long-term abuse of antibiotics can easily incur the prevalence of drug-resistant bacteria. Furthermore, antibiotics are not effective in addressing the excessive inflammatory response caused by infection. Here, we developed a terbium-doped zinc oxide constructed dual-light-responsive nitric oxide (NO)-releasing nanoparticle (ZT@P@B) and modified it on the surface of contact lenses (CL-ZT@P@B) to boost its bioavailability. In vitro and in vivo experimental results verified that ZT@P@B could simultaneously respond to green light (GL) and 808 nm near-infrared (NIR) without obvious damage to the eyes, releasing reactive oxygen species (ROS) and NO, which could effectively kill bacteria (including drug-resistant strains) and reduce inflammatory response. The platform provides a promising strategy for the prevention and treatment of BK.

Keywords

zinc oxidenitric oxidedual-light-responsivebacterial keratitiscontact lenses

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Nano Research
Volume 16 Issue 1,
January 2023
Pages 849-857
DOI: 10.1007/s12274-022-4744-1
Cite this article:
Sun Y, Zhang W, Wang M, et al. Terbium-doped zinc oxide constructed dual-light-responsive nitric oxide-releasing platform for bacterial keratitis treatment. Nano Research, 2023, 16(1): 849-857. https://doi.org/10.1007/s12274-022-4744-1
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Received: 11 May 2022
Revised: 30 June 2022
Accepted: 03 July 2022
Published: 17 August 2022
© Tsinghua University Press 2022
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