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Research Article

Fe-porphyrin: A redox-related biosensor of hydrogen molecule

Zhaokui Jin1,2, Penghe Zhao2, Wanjun Gong2, Wenjiang Ding1, Qianjun He1,2()
Center of Hydrogen Science, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
School of Biomedical Engineering, Health Science Center, Shenzhen University, 1066 Xueyuan Road, Shenzhen 518060, China
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Fe-porphyrin is revealed to be a H2-targeted molecule playing a redox-related biosensor/biocatalyst of H2, which is recognized to be an upstream signaling molecule of CO by Fe-porphyrin-catalytic reduction of CO2 into CO in the hypoxic microenvironment.

Abstract

Hydrogen molecule (H2) exhibits broad-spectrum but microenvironment-dependent biomedical effects in varied oxidation stress-related diseases, but its molecular mechanism is unclear and its targeting molecule is unknown so far. Herein, we originally reveal that Fe-porphyrin is a H2-targeted molecule. We have demonstrated that the oxidized Fe-porphyrin in both free and protein-confining states can self-catalyze the hydrogenation/reduction by reacting with H2 to catalytically scavenge ∙OH, and can also catalytically hydrogenate to reduce CO2 into CO in the hypoxic microenvironment of in vitro simulation and in vivo tumor, confirming that Fe-porphyrin is a redox-related biosensor of H2 and H2 is an upstream signaling molecule of CO. These discoveries are favorable for deep understanding and exploration of profound biomedical effects of H2, and helpful for development of innovative drugs and hydrogen energy/agricultural materials.

Keywords

hydrogen moleculemolecular mechanismmolecular targethydrogen medicineporphyrincatalysiscarbon monoxide

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Nano Research
Volume 16 Issue 2,
February 2023
Pages 2020-2025
DOI: 10.1007/s12274-022-4860-y
Cite this article:
Jin Z, Zhao P, Gong W, et al. Fe-porphyrin: A redox-related biosensor of hydrogen molecule. Nano Research, 2023, 16(2): 2020-2025. https://doi.org/10.1007/s12274-022-4860-y
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