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Review Article

Single-atom nanozymes: From bench to bedside

Chanyuan Jin1, Sanjun Fan2, Zechao Zhuang3( ), Yongsheng Zhou4 ( )
Second Dental Center, Peking University School and Hospital of Stomatology, Beijing 100101, China
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA
Department of Chemistry, Tsinghua University, Beijing 100084, China
Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
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Graphical Abstract

Schematic illustrates the single-atom nanozymes for biomedical applications.

Abstract

Single-atom nanozymes (SANs) are the new emerging catalytic nanomaterials with enzyme-mimetic activities, which have many extraordinary merits, such as low-cost preparation, maximum atom utilization, ideal catalytic activity, and optimized selectivity. With these advantages, SANs have received extensive research attention in the fields of chemistry, energy conversion, and environmental purification. Recently, a growing number of studies have shown the great promise of SANs in biological applications. In this article, we present the most recent developments of SANs in anti-infective treatment, cancer diagnosis and therapy, biosensing, and antioxidative therapy. This text is expected to better guide the readers to understand the current state and future clinical possibilities of SANs in medical applications.

Keywords

single-atom nanozymescancer therapybiosensinganti-infective treatmentantioxidative therapy

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Nano Research
Volume 16 Issue 2,
February 2023
Pages 1992-2002
DOI: 10.1007/s12274-022-5060-5
Cite this article:
Jin C, Fan S, Zhuang Z, et al. Single-atom nanozymes: From bench to bedside. Nano Research, 2023, 16(2): 1992-2002. https://doi.org/10.1007/s12274-022-5060-5
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Received: 07 August 2022
Revised: 12 September 2022
Accepted: 14 September 2022
Published: 08 November 2022
© Tsinghua University Press 2022
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