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Research Article

Selenium-engineered bottom-up-synthesized lanthanide coordination nanoframeworks as efficiency X-ray-responsive radiosensitizers

Liwen Zhu§, Leung Chan§, Junping Wang§, Mingkai Chen, Fei Cai, Yuan Tian, Li Ma( ), Tianfeng Chen( )
Department of Chemistry, and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou 510632, China

§ Liwen Zhu, Leung Chan, and Junping Wang contributed equally to this work.

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Graphical Abstract

This study presents a promising approach for effective radiotherapy through selenium-engineering stable lanthanide nanoframeworks with precise coordination structures as radiosensitizers to mitigate X-ray side effects.

Abstract

Radiotherapy is one of the main therapeutic methods for cancers; however, nonselective killing of normal cells and tumor cells by X-ray inevitably results in toxicity and side effects. Developing low-toxicity and high-efficiency radiosensitizers to reduce the practical dose of X-ray is a promising approach to overcoming these side effects. Here, we report the use of carboxylate-containing organic ligands to construct one-dimensional high-Z lanthanide chains for efficient response to X-ray. The one-dimensional lanthanide chains are stacked through weak interactions to form coordination nanoframeworks in the presence of polyethylenimine (PEI). The morphology and activity of the synthesized nanoframeworks can be regulated through selenium atom engineering. This study presents a promising approach for effective radiotherapy through selenium-engineering stable lanthanide nanoframeworks with precise coordination structures as radiosensitizers to mitigate X-ray side effects.

Keywords

seleniumlanthanide coordination nanoframeworksradiotherapyradiosensitizers

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Nano Research
Volume 16 Issue 4,
April 2023
Pages 5169-5175
DOI: 10.1007/s12274-022-5065-0
Cite this article:
Zhu L, Chan L, Wang J, et al. Selenium-engineered bottom-up-synthesized lanthanide coordination nanoframeworks as efficiency X-ray-responsive radiosensitizers. Nano Research, 2023, 16(4): 5169-5175. https://doi.org/10.1007/s12274-022-5065-0
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Received: 19 August 2022
Revised: 15 September 2022
Accepted: 16 September 2022
Published: 23 November 2022
© Tsinghua University Press 2022
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