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Research Article

Red organic light-emitting diodes based photobiomodulation therapy enabling prominent hair growth

Shuang-Qiao Sun1,§, Jing-Jing Shen1,§, Yu-Fei Wang1,§, Yu-Tong Jiang1, Lin-Fu Chen1, Hua Xin1,2,3, Jiang-Nan Wang3, Xiao-Bo Shi3, Xiao-Zhao Zhu3, Qi Sun1, Liang-Sheng Liao1,2,3, Qian Chen1( ), Man-Keung Fung1,2,3( ), Shuit-Tong Lee1,2,3( )
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, 199 Ren'ai Road, Suzhou 215123, China
Macao Institute of Materials Science and Engineering (MIMSE), MUST-SUDA Joint Research Center for Advanced Functional Materials, Zhuhai MUST Science and Technology Research Institute, Macau University of Science and Technology, Taipa 999078, Macau, China
Institute of Organic Optoelectronics, Jiangsu Industrial Technology Research Institute (JITRI), 1198 Fenhu Dadao, Wujiang, Suzhou 215200, China

§ Shuang-Qiao Sun, Jing-Jing Shen, and Yu-Fei Wang contributed equally to this work.

Show Author Information

Graphical Abstract

Red organic light-emitting diodes (OLEDs) can reactivate dormant hair follicle stem cells and regenerate new hair follicles: (i) increased autophagy during the anagen phase of the hair growth cycle; (ii) increased blood oxygen content promoted by the accelerated microvascular blood flow.

Abstract

Hair loss can cause psychological distress. Here, red organic light-emitting diode (OLED) light source is first introduced as the photobiomodulation therapy (PBMT) for hair growth and demonstrated as a promising and non-invasive therapeutic modality for alopecia. OLED exhibits unique advantages of homogeneous irradiation, flexible in form factor, and less heat generation. These features enable OLED to be an ideal candidate for wearable PBMT light sources. A systematic study of using red OLEDs to facilitate hair growth was conducted. The results show that OLEDs excellently promote hair regrowth. OLED irradiation can increase the length of the hair by a factor of 1.5 as compared to the control, and the hair regrowth area is enlarged by over 3 times after 20 days of treatments. Moreover, the mechanism of OLED that stimulates hair follicle regeneration is investigated in-vivo by conducting a systematic controlled experiments on mice with or without OLED PBMT. Based on the comprehensive histological and immunofluorescence staining studies, two key factors are identified for red OLEDs to facilitate hair follicle regeneration: (i) increased autophagy during the anagen phase of the hair growth cycle; (ii) increased blood oxygen content promoted by the accelerated microvascular blood flow.

Keywords

red organic light-emitting diode (OLED)light therapyhair growthautophagyoxygen saturation

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Nano Research
Volume 16 Issue 5,
May 2023
Pages 7164-7170
DOI: 10.1007/s12274-022-5315-1
Cite this article:
Sun S-Q, Shen J-J, Wang Y-F, et al. Red organic light-emitting diodes based photobiomodulation therapy enabling prominent hair growth. Nano Research, 2023, 16(5): 7164-7170. https://doi.org/10.1007/s12274-022-5315-1
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Received: 04 August 2022
Revised: 09 November 2022
Accepted: 09 November 2022
Published: 03 January 2023
© Tsinghua University Press 2022
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