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Review Article

Sensors-integrated organ-on-a-chip for biomedical applications

Hanxu Chen1Zhiqiang Luo1Xiang Lin1Yujuan Zhu1Yuanjin Zhao1,2( )
Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China
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Graphical Abstract

Organ-on-a-chip has been widely utilized for in vitro pharmaceutical study and tissues engineering based on the three-dimensional constructions of tissues/organs and delicate replication of in vivo-like microenvironment. We discuss the recent research advances made with respect to sensors-integrated organ-on-a-chip in this overall review.

Abstract

As a promising new micro-physiological system, organ-on-a-chip has been widely utilized for in vitro pharmaceutical study and tissues engineering based on the three-dimensional constructions of tissues/organs and delicate replication of in vivo-like microenvironment. To better observe the biological processes, a variety of sensors have been integrated to realize in-situ, real-time, and sensitive monitoring of critical signals for organs development and disease modeling. Herein, we discuss the recent research advances made with respect to sensors-integrated organ-on-a-chip in this overall review. Firstly, we briefly explore the underlying fabrication procedures of sensors within microfluidic platforms and several classifications of sensory principles. Then, emphasis is put on the highlighted applications of different types of organ-on-a-chip incorporated with various sensors. Last but not least, perspective on the remaining challenges and future development of sensors-integrated organ-on-a-chip are presented.

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Nano Research
Pages 10072-10099
Cite this article:
Chen H, Luo Z, Lin X, et al. Sensors-integrated organ-on-a-chip for biomedical applications. Nano Research, 2023, 16(7): 10072-10099. https://doi.org/10.1007/s12274-023-5651-9
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Received: 17 February 2023
Revised: 04 March 2023
Accepted: 07 March 2023
Published: 26 April 2023
© Tsinghua University Press 2023
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