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Research Article

Coordination-driven self-assembly of metallo-nanodrugs for local inflammation alleviation

Lijuan Tang1,2,3,§, Zhenghan Di3,§, Jingfang Zhang3, Feiying Yin1, Lele Li3( ), Li Zheng1( )
Guangxi Key Laboratory of Regenerative Medicine, Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration, Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development nd Application Co-Constructed by the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
Pharmaceutical College, Guangxi Medical University, Nanning 530021, China
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China

§ Lijuan Tang and Zhenghan Di contributed equally to this work.

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Graphical Abstract

An extremely simple yet efficient approach is presented to obtain hybrid nanodrugs through metal–drug coordination-driven self-assembly for anti-inflammatory therapy. This work highlights the development of anti-inflammatory nanoformulations by exploiting coordination-mediated self-assembly strategy.

Abstract

Developing dedicated nanomedicines to improve delivery efficacy of anti-inflammatory drugs is still a formidable challenge. In this study, we present an extremely simple yet efficient approach to obtain hybrid nanodrugs through metal-drug coordination-driven self-assembly for carrier-free drug delivery. The resulting metallo-nanodrugs exhibit well-defined morphology and high drug encapsulation capability, allowing for the combination of magnetic resonance imaging and anti-inflammatory therapy. In the case of osteoarthritis (OA), the metallo-nanodrugs remarkably alleviate synovial inflammation, preventing cartilage destruction and extracellular matrix loss. In addition, it led to significantly improved therapeutic efficacy compared with intra-articular administration of the same dose of free drugs in OA mouse model. This work provides a very simple approach for the development of anti-inflammatory nanoformulations by exploiting coordination-driven self-assembly.

Keywords

drug deliverycoordination-driven assemblynanomedicineanti-inflammation therapy

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Nano Research
Volume 16 Issue 12,
December 2023
Pages 13259-13266
DOI: 10.1007/s12274-023-5721-z
Cite this article:
Tang L, Di Z, Zhang J, et al. Coordination-driven self-assembly of metallo-nanodrugs for local inflammation alleviation. Nano Research, 2023, 16(12): 13259-13266. https://doi.org/10.1007/s12274-023-5721-z
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Received: 15 January 2023
Revised: 10 April 2023
Accepted: 10 April 2023
Published: 19 May 2023
© Tsinghua University Press 2023
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