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Research Article

Peroxidase-like single Fe atoms anchored on Ti3C2Tx MXene as surface enhanced Raman scattering substrate for the simultaneous discrimination of multiple antioxidants

Hongyan Xi1,§, Hongfei Gu2,§, Yurui Han3,§, Tingting You1, Pengfei Wu1, Qingqing Liu1, Lirong Zheng4, Shuhu Liu4, Qiang Fu5, Wenxing Chen2, Yukun Gao1, Yuting Wang1( ), Penggang Yin1( )
Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry, Beihang University, Beijing 100191, China
Energy & Catalysis Center, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China
Department of Chemical Physics, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230026, China
Institute of High Energy Physics, Chinese Academy of Science, Beijing 100029, China
School of Future Technology, University of Science and Technology of China, Hefei 230026, China

§ Hongyan Xi, Hongfei Gu, and Yurui Han contributed equally to this work.

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Graphical Abstract

We proposed an effective surface enhanced Raman scattering (SERS) sensor array based on Fe single atoms supported on Ti3C2Tx (Fe-SA/Ti3C2Tx) for the simultaneous discrimination of five antioxidants. The results showed that the as-prepared Fe-SA/Ti3C2Tx not only displays peroxidase-like activity with horseradish peroxidase (HRP), but also can be used as SERS substrate of oxidized 3,3',5,5'-tetramethylbenzidine (TMB+).

Abstract

Single-atom nanozymes (SAzymes) are emerging as promising alternatives to mimic natural enzyme, which is due to high atomic utilization efficiency, well-defined geometric, and unique electronic structure. Herein, Fe single atoms supported on Ti3C2Tx (Fe-SA/Ti3C2Tx) with intrinsic peroxidase activity is developed, further constructing a sensitive Raman sensor array for sensing of five antioxidants. Fe-SA/Ti3C2Tx shows excellent peroxidase-like performance in catalyzing the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) with colorimetric reactions. X-ray adsorption fine structure (XAFS) reveals that the electron transport between the Ti3C2Tx and Fe atoms occurs along Fe-O-Ti ligands, meanwhile the density functional theory (DFT) calculations confirm the spontaneous dissociation of H2O2 and the formation of OH radicals. Furthermore, the peroxidase-like Fe-SA/Ti3C2Tx was used as surface enhanced Raman scattering (SERS) substrate of oxidized TMB (TMB+) and achieved satisfied signal amplification performance. Using the blocking effects of free radical reactions, one-off identification of 5 antioxidants, including ascorbic acid (AA), uric acid (UA), glutathione (GSH), melatonin (Mel), and tea polyphenols (TPP), could be realized with this high identifiable catalytic property. This principle could realize 100% distinguish accuracy combined with linear discriminant analysis (LDA) and heat map data analysis. A wide detection concentration ranges from 10−8 to 10−3 M for five antioxidants was also achieved.

Keywords

single atom catalystTi3C2Tx MXeneatomic interface sitesurface enhanced Raman scattering (SERS)antioxidants

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Nano Research
Volume 16 Issue 7,
July 2023
Pages 10053-10060
DOI: 10.1007/s12274-023-5739-2
Cite this article:
Xi H, Gu H, Han Y, et al. Peroxidase-like single Fe atoms anchored on Ti3C2Tx MXene as surface enhanced Raman scattering substrate for the simultaneous discrimination of multiple antioxidants. Nano Research, 2023, 16(7): 10053-10060. https://doi.org/10.1007/s12274-023-5739-2
Topics:
Raman spectroscopy

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Received: 04 March 2023
Revised: 10 April 2023
Accepted: 13 April 2023
Published: 13 May 2023
© Tsinghua University Press 2023
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