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Research Article

Aptamer-functionalized nanoplatforms overcoming temozolomide resistance in synergistic chemo/photothermal therapy through alleviating tumor hypoxia

Yun Zeng1,3Linfei Zhao1,3Ke Li4Jingwen Ma5Dan Chen1,3Changhu Liu2Wenhua Zhan2( )Yonghua Zhan1,3( )
School of Life Science and Technology, Xidian University and Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, Xi’an 710126, China
Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan 750004, China
International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment and Xi’an Key Laboratory of Intelligent Sensing and Regulation of trans-Scale Life Information, School of Life Science and Technology, Xidian University, Xi’an 710126, China
Xi’an Key Laboratory for Prevention and Treatment of Common Aging Diseases, Translational and Research Centre for Prevention and Therapy of Chronic Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an 710021, China
Radiology Department, CT and MRI Room, Ninth Hospital of Xi’an, Xi’an 710054, China
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Graphical Abstract

To overcome temozolomide resistance in orthotopic gliomas, aptamer-functionalized liposomes are manufactured to encapsulate temozolomide and IR780 and can cross the blood-brain barrier and actively target gliomas.

Abstract

Tumor hypoxia is intimately associated with gliomas, which represents a significant threat to human health and are resistant to the first-line chemotherapeutic drug temozolomide (TMZ) due to hypoxia. In this work, to overcome TMZ resistance in orthotopic gliomas, aptamer-functionalized liposomes are manufactured to encapsulate TMZ and photothermal agent IR780, and can cross the blood-brain barrier and actively target gliomas. It is possible to employ liposomes for both fluorescence and photoacoustic imaging simultaneously due to their stability and excellent photothermal conversion capabilities. This chemo/photothermal synergistic therapeutic effect of liposomes on gliomas is demonstrated by their abilities to target orthotopic gliomas, alleviate tumor hypoxia and consequently reverse resistance of glioma cells to TMZ, thereby extending the survival time of tumor-bearing mice, making the nanoplatforms and their synergistic chemo/photothermal therapy as a potential clinical treatment for gliomas.

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Nano Research
Pages 9859-9872
Cite this article:
Zeng Y, Zhao L, Li K, et al. Aptamer-functionalized nanoplatforms overcoming temozolomide resistance in synergistic chemo/photothermal therapy through alleviating tumor hypoxia. Nano Research, 2023, 16(7): 9859-9872. https://doi.org/10.1007/s12274-023-5742-7
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Received: 02 January 2023
Revised: 11 April 2023
Accepted: 14 April 2023
Published: 22 May 2023
© Tsinghua University Press 2023
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