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Research Article

Early initiation of ARBs without blood pressure risk via neutrophil membrane-fused pH-sensitive liposomes to reduce cardiomyocyte apoptosis after acute myocardial infarction

Jinfeng Gao1,2,§, Wusiman Yakufu1,2,§, Hongbo Yang1,2,§, Yanan Song1,2, Qiaozi Wang1,2, Qiyu Li1,2, Haipeng Tan1,2, Jing Chen1,2, Dili Sun1,2, Zhengmin Wang1,2, Jinyan Zhang1,2, Xueyi Weng1,2, Juying Qian1,2, Zhiqing Pang4, Qibing Wang1,2( ), Zheyong Huang1,2( ), Junbo Ge1,2,3( )
Department of Cardiology, Zhongshan Hospital, Fudan University. Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China
National Clinical Research Center for Interventional Medicine& Shanghai Clinical Research Center for Interventional Medicine, 180 Feng Lin Road, Shanghai 200032, China
Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China
School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, 826 Zhangheng Road, Shanghai 200032, China

§ Jinfeng Gao, Wusiman Yakufu, and Hongbo Yang contributed equally to this work.

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Graphical Abstract

This study discusses the activation of the local renin-angiotensin system (RAS) after a heart attack and the potential for it to cause cardiomyocyte apoptosis. We developed a platform, NSLP-Val, to block the angiotensin II-AT1R (angiotensin type 1 receptor) axis, which can induce apoptosis, and tested its targeting ability to bind to human umbilical vein endothelial cells (HUVECs) in vitro and therapeutic effect in vivo.

Abstract

Activation of the local renin–angiotensin system (RAS) promotes cardiomyocyte apoptosis and cardiac remodeling after acute myocardial infarction (AMI). As an anti-RAS drug, the effect of Valsartan in the early stage of acute MI is limited by its low drug concentration in the heart and low dosage. Here, by exploiting the inherent nature of neutrophils migrating to the injured myocardium and the local low-pH microenvironment caused by ischemia and hypoxia after myocardial infarction, we designed nanocarrier (NSLP)-hybridized neutrophil membranes and pH-sensitive liposomes (SLPs) for the delivery of Valsartan (NSLP-Val). These functional nanocarriers could mimic neutrophils and are homed to the injured heart; they were also found to respond to a low-pH microenvironment. In the mouse model of MI, we found that NSLP-Val could target the infarct marginal zone and release Valsartan locally in the low-pH microenvironment without affecting hemodynamic stability. Further, locally released angiotensin receptor inhibitors reduced the infarct size and inflammatory response by inhibiting cardiomyocytes. Ultimately, NSLP-Val improved cardiac function and inhibited cardiac hypertrophy and fibrosis.

Keywords

Valsartanearly initiationcardiomyocyte apoptosisblood pressuremyocardial infarction

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Nano Research
Volume 16 Issue 7,
July 2023
Pages 9894-9905
DOI: 10.1007/s12274-023-5846-0
Cite this article:
Gao J, Yakufu W, Yang H, et al. Early initiation of ARBs without blood pressure risk via neutrophil membrane-fused pH-sensitive liposomes to reduce cardiomyocyte apoptosis after acute myocardial infarction. Nano Research, 2023, 16(7): 9894-9905. https://doi.org/10.1007/s12274-023-5846-0
Topics:
Cardiovascular system

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Received: 10 March 2023
Revised: 16 May 2023
Accepted: 18 May 2023
Published: 17 June 2023
© Tsinghua University Press 2023
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