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Research Article

Engineering hierarchical metal-organic@metal-DNA heterostructures for combinational tumor treatment

Xueyan Feng1,2,§, Bei Liu1,§, Zehao Zhou1,§, Wei Li3, Jian Zhao1,2( ), Lele Li1,2( ), Yuliang Zhao1,2( )
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Department of Nanomedicine & Shanghai Key Lab of Cell Engineering, Naval Medical University, Shanghai 200433, China

§ Xueyan Feng, Bei Liu, and Zehao Zhou contributed equally to this work.

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Graphical Abstract

Hierarchical metal-organic@metal-DNA nanostructures are fabricated through self-assembly of DNA and metal ions on nanoscale metal-organic frameworks. The hetero-architectures enable enhanced anti-tumor efficacy through the integration of gene therapy and chemotherapy with photodynamic therapy.

Abstract

Development of simple methods for controlled integration of DNA molecules with metal-organic frameworks (MOFs) is important for various biomedical applications, yet remains a challenge. Herein, a simple and general approach to load DNA on the surface of MOFs is developed via one-pot self-assembly of DNA and FeII ions on nanoscale MOFs, resulting in hierarchical core-shell nanostructures of metal-organic@metal-DNA coordination polymers. The strategy enables assembly of DNA molecules on MOFs with ultra-high contents and precise controllability. By incorporation of a chemotherapeutic drug into the Fe-DNA shell, the systems allow to integrate chemotherapy and gene therapy with photodynamic therapy for combinational tumor treatment. Moreover, the hybrid nanostructures enable light-triggered production of cytotoxic singlet oxygen, which further boosts the endosomal escape of the system for an enhanced gene silencing efficacy and thus improved therapeutic outcome. This work highlights a robust approach for the construction of coordination-based drug delivery systems to combat tumor.

Keywords

metal-organic frameworksDNAhierarchical nanostructurescoordinationcombinational tumor treatment

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Nano Research
Volume 16 Issue 11,
November 2023
Pages 12633-12640
DOI: 10.1007/s12274-023-5909-2
Cite this article:
Feng X, Liu B, Zhou Z, et al. Engineering hierarchical metal-organic@metal-DNA heterostructures for combinational tumor treatment. Nano Research, 2023, 16(11): 12633-12640. https://doi.org/10.1007/s12274-023-5909-2
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Received: 17 April 2023
Revised: 08 June 2023
Accepted: 09 June 2023
Published: 01 July 2023
© Tsinghua University Press 2023
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