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Review Article

Assembly of peptide nanostructures with controllable sizes

Dan Cheng1Fan Jia1Yun-Bao Jiang1,2Vincent P. Conticello3( )Tao Jiang1,2( )
The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen 361005, China
Department of Chemistry, Emory University, Atlanta 30033, USA
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Graphical Abstract

Current progress in the regulation of peptide assembly size through implementation of molecular design is surveyed.

Abstract

Controlled peptide assembly offers significant promise to develop synthetic supramolecular nanostructures to display material and biological properties that mimic protein assemblies in nature. Despite the progress in forming peptide nanostructures of various morphology, there exists a distinct gap between natural and synthetic assembly systems in terms of size control. Constructing nanostructures with a narrow size distribution that can be tuned over a wide range of length-scales is essential for applications that require precise spacing between objects. This approach provides the opportunity to correlate materials and biological properties of interest with assembly size. In this review, we discuss representative endeavors over the past two decades for design of size-controllable peptide nanostructures using tunable building blocks. Other mechanisms for size control, e.g., molecular frustration, template-directed peptide assembly, and multi-component peptide co-assembly, will also be discussed. We also demonstrate the applicable scopes of these strategies and suggest potential future avenues for scientific advances in this field.

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Nano Research
Pages 151-161
Cite this article:
Cheng D, Jia F, Jiang Y-B, et al. Assembly of peptide nanostructures with controllable sizes. Nano Research, 2024, 17(1): 151-161. https://doi.org/10.1007/s12274-023-5970-x
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Received: 29 April 2023
Revised: 29 June 2023
Accepted: 30 June 2023
Published: 26 July 2023
© Tsinghua University Press 2023
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