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Research Article

PD-L1-driven efficient enrichment and elimination of circulating cancer cells by magnetic MoSe2 nanosheet

Hongjie Huang1,2,§, Binhua Zou1,2,3,§, Shanlin Zhu2, Xingchen Zhang2, Jiale Huang2, Jinlin Wang4( ), Xiaoling Li1,2( ), Tianfeng Chen1( )
The Sixth Affiliated Hospital, Jinan University, Dongguan 523566, China
Department of Chemistry, Institute of Food Safety and Nutrition, Jinan University, Guangzhou 510632, China
Department of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China

§ Hongjie Huang and Binhua Zou contributed equally to this work.

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Graphical Abstract

Conceptual diagram of the anti-PD-L1-MoSe2@Fe3O4@PDA nanosheets (PD-L1-MFP NS) synthesis route, circulating tumor cell (CTC) capture, and the role of photothermal therapy combined with natural killer (NK) cells to kill CTCs.

Abstract

Circulating tumor cells (CTCs) are important biomarkers in the development and progression of lung cancer because they can reach other organs through the blood circulation and form distant metastases, exacerbating lung cancer progression. The presence of CTCs is also the main reason for the failure of nanomedicine-based lung cancer treatments. Therefore, magnetic MoSe2 nanosheets loaded with programmed death-ligand 1 (PD-L1), named PD-L1-MFP NS, were employed here to precisely capture lung cancer CTCs in the blood circulation through the tumor-targeting effect of PD-L1 killing CTCs with highly effective photothermal therapy (PTT). In addition, by increasing the expression of cytomegalovirus UL16-binding protein (ULBP) ligands on tumor cells, the PD-L1-MFP NS further activated natural killer (NK) cells and triggered NK cell-induced cancer immunotherapy, thereby enhancing the overall tumor-killing effect. In summary, this material designed to capture CTCs provides a substantial advancement for personalized PTT-triggered immunotherapy and has great clinical translational potential.

Keywords

circulating tumor cellsselenidephotothermal therapy (PTT)natural killer (NK) cellimmunotherapy

Electronic Supplementary Material

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Nano Research
Volume 17 Issue 5,
May 2024
Pages 4350-4358
DOI: 10.1007/s12274-023-6342-2
Cite this article:
Huang H, Zou B, Zhu S, et al. PD-L1-driven efficient enrichment and elimination of circulating cancer cells by magnetic MoSe2 nanosheet. Nano Research, 2024, 17(5): 4350-4358. https://doi.org/10.1007/s12274-023-6342-2
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Received: 23 September 2023
Revised: 14 November 2023
Accepted: 16 November 2023
Published: 20 December 2023
© Tsinghua University Press 2023
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