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Review Article

Targeted nanostrategies eliminate pre-metastatic niche of cancer

Juan Wang1,2,3, Ning Zhang4, Xiuping Ding3, Chengrui Fu3, Xiaodong Li3( ), Baosheng Li3( ), Jianxun Ding2,5( ), Tianmeng Sun1( )
Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, 1 Xinmin Street, Changchun 130061, China
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan 250117, China
Department of orthopaedics, The Second Hospital of Shandong University, Shandong University, 247 Beiyuan Street, Jinan 250033, China
State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai 200433, China
Show Author Information

Graphical Abstract

The primary tumor promotes metastases by inducing the formation of pre-metastatic niche (PMN). Targeting the critical phases in the evolution of PMN by advanced nanostrategies potentially inhibits the establishment of distant metastases.

Abstract

Establishing a pre-metastatic niche (PMN) in secondary organs is a prerequisite for cancer metastases. Despite advances in cancer therapy, the efficient inhibition of PMN formation remains a clinical challenge. Recent advances in understanding the specific characteristics of PMN and advances in nanotechnology have provided hope for manipulating their microenvironments. A series of nanostrategies have been designed to eliminate the PMN, including the removal of pro-metastatic exosomes from the bloodstream for excretion via the intestines, the targeting and scavenging of myeloid-derived suppressor cells, fibroblasts, and critical extracellular matrix components, and the elimination of circulating tumor cells prior to colonization in distant organs. This review summarizes the underlying mechanisms of PMN formation, highlights the anti-PMN efficacy of currently reported nanostrategies, and underlines the unresolved questions.

Keywords

nanoparticlecontrolled drug deliverypre-metastatic niche eliminationmetastasis suppressioncancer therapy

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Nano Research
Volume 17 Issue 6,
June 2024
Pages 5358-5373
DOI: 10.1007/s12274-024-6412-0
Cite this article:
Wang J, Zhang N, Ding X, et al. Targeted nanostrategies eliminate pre-metastatic niche of cancer. Nano Research, 2024, 17(6): 5358-5373. https://doi.org/10.1007/s12274-024-6412-0
Topics:
Biomaterials Controlled drug deliveryDrug therapyMedical nanotechnologyNanobiotechnologyNanoparticlesSelf assembly

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Received: 19 September 2023
Revised: 08 December 2023
Accepted: 11 December 2023
Published: 08 February 2024
© Tsinghua University Press 2024
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