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Antibiotics are a widely used and effective treatment for bacterial infections. However, bacteria can gradually evolve during infection, leading to developing resistance to antibiotics, which renders previously effective treatments ineffective. Finding a useful and convenient manner to treat bacterial infections is a great challenge. Here, we report a flexible hydrogen-bond-bridged phosphorene film with photodynamic antibacterial properties and excellent mechanical properties, fabricated from electrochemical exfoliation of black phosphorus (BP). When illuminated under 700 nm light, the hydrogen bond-bridged phosphorene flexible film is capable of converting ground-state triplet oxygen (O2) into excited-state singlet oxygen (1O2), destroying the structure of the membrane of Staphylococcus aureus, and eventually leading to bacterial death, via breaking the C=C of unsaturated fatty acids within the bacterial cell membrane after the reaction between 1O2 and unsaturated fatty acids, thus realizing a highly efficient antibacterial approach, which is supported by gas chromatography-mass spectrometry (GC-MS) technique. This work establishes an effective phototherapy platform for treating bacterial traumatic infections.
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