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Research Article | Open Access

Synthesis of carbon nanotubes loaded hydroxyapatite: Potential for controlled drug release from bone implants

Lisa COSTANTINIa, Nikolaos BOUROPOULOSb,c, Dimitrios G. FATOUROSd, Ioanna KONTOPOULOUb, Marta ROLDOa( )
School of Pharmacy and Biomedical Science, University of Portsmouth, St Michael’s Building, White Swan Road, Portsmouth, UK
Department of Materials Science, University of Patras, 26504 Rio, Patras, Greece
Foundation for Research and Technology, Hellas–Institute of Chemical Engineering and High Temperature Chemical Processes—FORTH/ICEHT, P.O. Box 1414, GR 26504 Patras, Greece
Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece
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Abstract

Carbon nanotubes (CNTs) can support the building of flexible and porous scaffolds for bone regeneration. Various studies have looked at the mixing of CNTs with hydroxyapaptite for the formulation of bone implants. In the present work, we report the one step preparation and characterisation of chitosan/hydroxyapatite/CNTs composite materials obtained by wet precipitation of hydroxyapatite (HA) in the presence of chitosan or its amphiphilic derivative N-octyl-O-sulphate chitosan and CNTs. The in situ precipitation of HA assured inclusion of the polysaccharide and the CNTs in the HA structure and provided materials with the ability to control the release of different model drugs.

Keywords

carbon nanotubes (CNTs)hydroxyapatite (HA) compositesbone regenerationchitosan

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Journal of Advanced Ceramics
Volume 5 Issue 3,
September 2016
Pages 232-243
DOI: 10.1007/s40145-016-0195-z
Cite this article:
COSTANTINI L, BOUROPOULOS N, FATOUROS DG, et al. Synthesis of carbon nanotubes loaded hydroxyapatite: Potential for controlled drug release from bone implants. Journal of Advanced Ceramics, 2016, 5(3): 232-243. https://doi.org/10.1007/s40145-016-0195-z

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Received: 02 March 2016
Revised: 10 June 2016
Accepted: 11 June 2016
Published: 21 August 2016
© The author(s) 2016

Open Access The articles published in this journal are distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons. org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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