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Research Article | Open Access

High performance hydroxyapatite ceramics and a triply periodic minimum surface structure fabricated by digital light processing 3D printing

Yongxia YAOa,†, Wei QINb,c,†, Bohang XINGa, Na SHAd( ), Ting JIAOb,c( ), Zhe ZHAOa( )
School of Material Science and Engineering, Shanghai Institute of Technology, Shanghai 201418, China
Department of Prosthodontics, Shanghai Ninth People's Hospital, College of Stomatology, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China
Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai 200011, China
School of Chemical and Environment Engineering, Shanghai Institute of Technology, Shanghai 201418, China

† Yongxia Yao and Wei Qin contributed equally to this work.

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Abstract

High performance hydroxyapatite (HA) ceramics with excellent densification and mechanical properties were successfully fabricated by digital light processing (DLP) three-dimensional (3D) printing technology. It was found that the sintering atmosphere of wet CO2 can dramatically improve the densification process and thus lead to better mechanical properties. HA ceramics with a relative density of 97.12% and a three-point bending strength of 92.4 MPa can be achieved at a sintering temperature of 1300 ℃, which makes a solid foundation for application in bone engineering. Furthermore, a relatively high compressive strength of 4.09 MPa can be also achieved for a DLP-printed p-cell triply periodic minimum surface (TPMS) structure with a porosity of 74%, which meets the requirement of cancellous bone substitutes. A further cell proliferation test demonstrated that the sintering atmosphere of wet CO2 led to improve cell vitality after 7 days of cell culture Moreover, with the possible benefit from the bio-inspired structure, the 3D-printed TPMS structure significantly improved the cell vitality, which is crucial for early osteogenesis and osteointegration.

Keywords

hydroxyapatite (HA)3D printingsintering atmospheremechanical propertybioactivitydigital light processing (DLP)

References

[1]
GB Wei, PX Ma. Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering. Biomaterials 2004, 25: 4749-4757.
Crossref Google Scholar
[2]
KF Lin, S He, Y Song, et al. Low-temperature additive manufacturing of biomimic three-dimensional hydroxyapatite/ collagen scaffolds for bone regeneration. ACS Appl Mater Interfaces 2016, 8: 6905-6916.
Crossref Google Scholar
[3]
MA Nowicki, NJ Castro, MW Plesniak, et al. 3D printing of novel osteochondral scaffolds with graded microstructure. Nanotechnology 2016, 27: 414001.
Crossref Google Scholar
[4]
RY Chen, WB Jia, DQ Hei, et al. Toward excellent performance of Al2O3-ZrO2 reticulated porous ceramics: New insights based on residual stress. Ceram Int 2018, 44: 21478-21485.
Crossref Google Scholar
[5]
SY Fu, M Zhu, YF Zhu. Organosilicon polymer-derived ceramics: An overview. J Adv Ceram 2019, 8: 457-478.
Crossref Google Scholar
[6]
DW Hutmacher. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000, 21: 2529-2543.
Crossref Google Scholar
[7]
K Rezwan, QZ Chen, JJ Blaker, et al. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 2006, 27: 3413-3431.
Crossref Google Scholar
[8]
PJ Bártolo, CK Chua, HA Almeida, et al. Biomanufacturing for tissue engineering: Present and future trends. Virtual Phys Prototyp 2009, 4: 203-216.
Crossref Google Scholar
[9]
SM Giannitelli, D Accoto, M Trombetta, et al. Current trends in the design of scaffolds for computer-aided tissue engineering. Acta Biomater 2014, 10: 580-594.
Crossref Google Scholar
[10]
SC Kapfer, ST Hyde, K Mecke, et al. Minimal surface scaffold designs for tissue engineering. Biomaterials 2011, 32: 6875-6882.
Crossref Google Scholar
[11]
DJ Yoo. Porous scaffold design using the distance field and triply periodic minimal surface models. Biomaterials 2011, 32: 7741-7754.
Crossref Google Scholar
[12]
JP Shi, JQ Yang, LY Zhu, et al. A porous scaffold design method for bone tissue engineering using triply periodic minimal surfaces. IEEE Access 2018, 6: 1015-1022.
Crossref Google Scholar
[13]
D Ali, M Ozalp, SBG Blanquer, et al. Permeability and fluid flow-induced wall shear stress in bone scaffolds with TPMS and lattice architectures: A CFD analysis. Eur J Mech-B 2020, 79: 376-385.
Crossref Google Scholar
[14]
L Li, JP Shi, KJ Zhang, et al. Early osteointegration evaluation of porous Ti6Al4V scaffolds designed based on triply periodic minimal surface models. J Orthop Transl 2019, 19: 94-105.
Crossref Google Scholar
[15]
Y Jung, KT Chu, S Torquato. A variational level set approach for surface area minimization of triply-periodic surfaces. J Comput Phys 2007, 223: 711-730.
Crossref Google Scholar
[16]
Y Jung, S Torquato. Fluid permeabilities of triply periodic minimal surfaces. Phys Rev E 2005, 72: 056319.
Crossref Google Scholar
[17]
JK Guest, JH Prévost. Optimizing multifunctional materials: Design of microstructures for maximized stiffness and fluid permeability. Int J Solids Struct 2006, 43: 7028-7047.
Crossref Google Scholar
[18]
B Bhushan, M Caspers. An overview of additive manufacturing (3D printing) for microfabrication. Microsyst Technol 2017, 23: 1117-1124.
Crossref Google Scholar
[19]
M Lasgorceix, E Champion, T Chartier. Shaping by microstereolithography and sintering of macro-micro-porous silicon substituted hydroxyapatite. J Eur Ceram Soc 2016, 36: 1091-1101.
Crossref Google Scholar
[20]
J Brie, T Chartier, C Chaput, et al. A new custom made bioceramic implant for the repair of large and complex craniofacial bone defects. J Cranio-Maxillofac Surg 2013, 41: 403-407.
Crossref Google Scholar
[21]
SC Cox, JA Thornby, GJ Gibbons, et al. 3D printing of porous hydroxyapatite scaffolds intended for use in bone tissue engineering applications. Mater Sci Eng: C 2015, 47: 237-247.
Crossref Google Scholar
[22]
HP Shao, JZ He, T Lin, et al. 3D gel-printing of hydroxyapatite scaffold for bone tissue engineering. Ceram Int 2019, 45: 1163-1170.
Crossref Google Scholar
[23]
ZB Liu, HX Liang, TS Shi, et al. Additive manufacturing of hydroxyapatite bone scaffolds via digital light processing and in vitro compatibility. Ceram Int 2019, 45: 11079-11086.
Crossref Google Scholar
[24]
S Zhang, N Sha, Z Zhao. Surface modification of α-Al2O3 with dicarboxylic acids for the preparation of UV-curable ceramic suspensions. J Eur Ceram Soc 2017, 37: 1607-1616.
Crossref Google Scholar
[25]
KH Li, Z Zhao. The effect of the surfactants on the formulation of UV-curable SLA alumina suspension. Ceram Int 2017, 43: 4761-4767.
Crossref Google Scholar
[26]
YX Yao, N Sha, Z Zhao. Highly concentrated hydroxyapatite suspension for DLP printing. IOP Conf Ser: Mater Sci Eng 2019, 678: 012016.
Crossref Google Scholar
[27]
BH Xing, YX Yao, X Meng, et al. Self-supported yttria-stabilized zirconia ripple-shaped electrolyte for solid oxide fuel cells application by digital light processing three-dimension printing. Scripta Mater 2020, 181: 62-65.
Crossref Google Scholar
[28]
JW Stansbury, MJ Idacavage. 3D printing with polymers: Challenges among expanding options and opportunities. Dent Mater 2016, 32: 54-64.
Crossref Google Scholar
[29]
CW Feng, KQ Zhang, RJ He, et al. Additive manufacturing of hydroxyapatite bioceramic scaffolds: Dispersion, digital light processing, sintering, mechanical properties, and biocompatibility. J Adv Ceram 2020, 9: 360-373.
Crossref Google Scholar
[30]
S Bose, SK Saha. Synthesis of hydroxyapatite nanopowders via sucrose-templated Sol-gel method. J Am Ceram Soc 2003, 86: 1055-1057.
Crossref Google Scholar
[31]
ZH Cheng, A Yasukawa, K Kandori, et al. FTIR Study on incorporation of CO2 into calcium hydroxyapatite. Faraday Trans 1998, 94: 1501-1505.
Crossref Google Scholar
[32]
F Scalera, C Esposito Corcione, F Montagna, et al. Development and characterization of UV curable epoxy/ hydroxyapatite suspensions for stereolithography applied to bone tissue engineering. Ceram Int 2014, 40: 15455-15462.
Crossref Google Scholar
[33]
A Rapacz-Kmita, A Ślósarczyk, Z Paszkiewicz. Mechanical properties of HAp-ZrO2 composites. J Eur Ceram Soc 2006, 26: 1481-1488.
Crossref Google Scholar
[34]
IR Gibson, W Bonfield. Novel synthesis and characterization of an AB-type carbonate-substituted hydroxyapatite. J Biomed Mater Res 2002, 59: 697-708.
Crossref Google Scholar
[35]
HX Zhao, WH Liang. A novel comby scaffold with improved mechanical strength for bone tissue engineering. Mater Lett 2017, 194: 220-223.
Crossref Google Scholar
[36]
EL Herzog, L Chai, DS Krause. Plasticity of marrow-derived stem cells. Blood 2003, 102: 3483-3493.
Crossref Google Scholar
[37]
A González-Vázquez, JA Planell, E Engel. Extracellular calcium and CaSR drive osteoinduction in mesenchymal stromal cells. Acta Biomater 2014, 10: 2824-2833.
Crossref Google Scholar
[38]
AS Curtis, JV Forrester, C McInnes, et al. Adhesion of cells to polystyrene surfaces. J Cell Biol 1983, 97: 1500-1506.
Crossref Google Scholar
[39]
XM Liu, JY Lim, HJ Donahue, et al. Influence of substratum surface chemistry/energy and topography on the human fetal osteoblastic cell line hFOB 1.19: Phenotypic and genotypic responses observed in vitro. Biomaterials 2007, 28: 4535-4550.
Crossref Google Scholar
[40]
LL Hench. Bioceramics: from concept to clinic. J Am Ceram Soc 1991, 74: 1487-1510.
Crossref Google Scholar
[41]
S Van Bael, YC Chai, S Truscello, et al. The effect of pore geometry on the in vitro biological behavior of human periosteum-derived cells seeded on selective laser-melted Ti6Al4V bone scaffolds. Acta Biomater 2012, 8: 2824-2834.
Crossref Google Scholar
Journal of Advanced Ceramics
Volume 10 Issue 1,
February 2021
Pages 39-48
DOI: 10.1007/s40145-020-0415-4
Cite this article:
YAO Y, QIN W, XING B, et al. High performance hydroxyapatite ceramics and a triply periodic minimum surface structure fabricated by digital light processing 3D printing. Journal of Advanced Ceramics, 2021, 10(1): 39-48. https://doi.org/10.1007/s40145-020-0415-4

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Received: 03 June 2020
Revised: 23 August 2020
Accepted: 25 August 2020
Published: 18 January 2021
© The Author(s) 2020

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