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Research Article | Open Access

Stable oral lubrication enhancer obtained from thiolated polyethylene glycol and mucin

Xiaoyan HE1,2, Pravin SMART1, Mohamad TAUFIQURRAKHMAN1, Chun WANG1, Michael BRYANT1( )
Institute of Functional Surfaces, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom
Reliability Engineering Institute, National Engineering Research Center for Water Transport Safety, Wuhan University of Technology, Wuhan 430063, China
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Abstract

Mucins are vital components contributing to the unique lubrication properties of human whole saliva. For patients receiving medication and or treatment such as diabetes or radiotherapy, xerostomia (dry mouth) is a common with numerous and deleterious side effects. Although products exist on the market to relive the symptoms of Xerostomia there remains a drive to formulate a biocompatible lubricant that replicate the functionality offered by the natural biological environment. Herein, a combination of mucin and thiolated polyethylene glycol (PEG-SH) was proposed as a new saliva substitute. Mucin and PEG-SH molecules could form hydrated layers immediately by chemisorption. Meanwhile, the chemical interactions between mucin and PEG-SH molecules also promoted the formation of a mixed layer. All the pre-formed layers could decrease friction and had the potential to decrease wear, especially mucin and PEG-SH mixed layer when compared to mucin only solutions. Further investigations of tribological mechanism implied that the excellent lubrication performance of mixed layer with long effectiveness was contributed to the friction-reducing effect of PEG/mucin molecules and the mucoadhesive property of mucin. The study provides a guide for using mucin as a mucoadhesive agent to stable lubricative polymers with low molecular weight as novel salivary substitutes for lubrication.

Keywords

lubricationmucinpolyethylene glycolmucoadhesivechemisorption

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Friction
Volume 11 Issue 4,
April 2023
Pages 617-634
DOI: 10.1007/s40544-022-0629-2
Cite this article:
HE X, SMART P, TAUFIQURRAKHMAN M, et al. Stable oral lubrication enhancer obtained from thiolated polyethylene glycol and mucin. Friction, 2023, 11(4): 617-634. https://doi.org/10.1007/s40544-022-0629-2

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Received: 23 October 2021
Revised: 19 December 2021
Accepted: 01 April 2022
Published: 16 July 2022
© The author(s) 2022.

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