AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Friction Article
PDF (3.2 MB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Research Article | Open Access

Synovial fluid-inspired biomimetic lubricating microspheres: Zwitterionic polyelectrolyte brushes-grafted microgels

Guoqiang LIU1,†( ), Yang FENG1,†, Xiaohua GAO1, Zhuo CHEN1, Nan ZHAO1, Feng ZHOU1,2 ( ), Weimin LIU1,2
Center of Advanced Lubrication and Seal Materials, State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi’an 710072, China
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China

† Guoqiang LIU and Yang FENG contributed equally to this work.

Show Author Information

Abstract

Synovial fluid is made up of various biomacromolecules, including hyaluronic acid, aggrecans, lubricins, and phosphatidylcholine lipid, which are assembled onto the surface of articular cartilage in a gel state. Among them, brush-like biomacromolecules or assemblies have a vital effect on human joint lubrication. Inspired by this, the combination of brush-like molecular structures and gel-like assembly may be an efficient approach for the synthesis of biomimetic lubricating matters. Learning from the lubrication system of human joints, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) brushes grafted poly(N-isopropylacrylamide-co-acrylic acid) (poly(NIPAAm-co-AA)) microgels, abbreviated as MBs-g-MGs, were synthesized as one kind of biomimetic lubricating additives. It is worth noting that this bionic strategy considered both molecular structure and assembled form, which enabled this hairy microgel to achieve low friction in aqueous medium. Meanwhile, the effective lubrication was still achieved when using MBs-g-MGs at high temperature, indicating that this microgel maintains a good lubricating effect over a wide range of temperature. In addition, this kind of microgel possessed good biocompatibility, which laid the foundation for potential biomedical applications. Looking beyond, these biomimetic microgels may provide an effective lubricating effect for water-based sliding interfaces, especially in biomedical systems.

Keywords

biomimetic designzwitterionic polyelectrolyte brushespolymeric microgelsaqueous lubrication

References

[1]
Cooper B G, Catalina B, Nazarian A, Snyder B D, Grinstaff M W. Active agents, biomaterials, and technologies to improve biolubrication and strengthen soft tissues. Biomaterials 181: 210–226 (2018)
Google Scholar
[2]
Jahn S, Seror J, Klein J. Lubrication of articular cartilage. Annu Rev Biomed Eng 18: 235–258 (2016)
Google Scholar
[3]
Dėdinaitė A. Biomimetic lubrication. Soft Matter 8(2): 273–284 (2012)
Google Scholar
[4]
Lin W F, Klein J. Recent progress in cartilage lubrication. Adv Mater 33(18): 2005513 (2021)
Google Scholar
[5]
Klein J. Polymers in living systems: From biological lubrication to tissue engineering and biomedical devices. Polym Adv Technol 23(4): 729–735 (2012)
Google Scholar
[6]
Lee S, Spencer N D. Sweet, hairy, soft, and slippery. Science 319(5863): 575–576 (2008)
Google Scholar
[7]
Seror J, Zhu L Y, Goldberg R, Day A J, Klein J. Supramolecular synergy in the boundary lubrication of synovial joints. Nat Commun 6: 6497 (2015)
Google Scholar
[8]
Morgese G, Benetti E M, Zenobi-Wong M. Molecularly engineered biolubricants for articular cartilage. Adv Healthc Mater 7(16): 1701463 (2018)
Google Scholar
[9]
Ma S H, Scaraggi M, Wang D A, Wang X L, Liang Y M, Liu W M, Dini D, Zhou F. Nanoporous substrate-infiltrated hydrogels: A bioinspired regenerable surface for high load bearing and tunable friction. Adv Funct Mater 25(47): 7366–7374 (2015)
Google Scholar
[10]
Liu G Q, Cai M R, Zhou F, Liu W M. Charged polymer brushes-grafted hollow silica nanoparticles as a novel promising material for simultaneous joint lubrication and treatment. J Phys Chem B 118(18): 4920–4931 (2014)
Google Scholar
[11]
Green J J, Elisseeff J H. Mimicking biological functionality with polymers for biomedical applications. Nature 540(7633): 386–394 (2016)
Google Scholar
[12]
Liu G Q, Feng Y, Zhao N, Chen Z, Shi J Q, Zhou F. Polymer-based lubricating materials for functional hydration lubrication. Chem Eng J 429: 132324 (2022)
Google Scholar
[13]
Chen Z, Feng Y, Zhao N, Liu Y N, Liu G Q, Zhou F, Liu W M. Near-infrared-light-modulated lubricating coating enabled by photothermal microgels. ACS Appl Mater Interfaces 13(41): 49322–49330 (2021)
Google Scholar
[14]
Raviv U, Giasson S, Kampf N, Gohy J F, Jérôme R, Klein J. Lubrication by charged polymers. Nature 425(6954): 163–165 (2003)
Google Scholar
[15]
Ma L R, Gaisinskaya-Kipnis A, Kampf N, Klein J. Origins of hydration lubrication. Nat Commun 6: 6060 (2015)
Google Scholar
[16]
Klein J. Hydration lubrication. Friction 1(1): 1–23 (2013)
Google Scholar
[17]
Chen M, Briscoe W H, Armes S P, Klein J. Lubrication at physiological pressures by polyzwitterionic brushes. Science 323(5922): 1698–1701 (2009)
Google Scholar
[18]
Wathier M, Lakin B A, Bansal P N, Stoddart S S, Snyder B D, Grinstaff M W. A large-molecular-weight polyanion, synthesized via ring-opening metathesis polymerization, as a lubricant for human articular cartilage. J Am Chem Soc 135(13): 4930–4933 (2013)
Google Scholar
[19]
Banquy X, Burdyńska J, Lee D W, Matyjaszewski K, Israelachvili J. Bioinspired bottle-brush polymer exhibits low friction and amontons-like behavior. J Am Chem Soc 136(17): 6199–6202 (2014)
Google Scholar
[20]
Faivre J, Shrestha B R, Burdynska J, Xie G J, Moldovan F, Delair T, Benayoun S, David L, Matyjaszewski K, Banquy X. Wear protection without surface modification using a synergistic mixture of molecular brushes and linear polymers. ACS Nano 11(2): 1762–1769 (2017)
Google Scholar
[21]
Plamper F A, Richtering W. Functional microgels and microgel systems. Acc Chem Res 50(2): 131–140 (2017)
Google Scholar
[22]
Li B, Kappl M, Han L, Cui J X, Zhou F, del Campo A. Goosebumps-inspired microgel patterns with switchable adhesion and friction. Small 15(35): 1902376 (2019)
Google Scholar
[23]
Chen Z, Feng Y, Zhao N, Shi J Q, Liu G Q, Liu W M. Near-infrared photothermal microgel for interfacial friction control. ACS Appl Polym Mater 3(8): 4055–4061 (2021)
Google Scholar
[24]
Liu G Q, Cai M R, Wang X L, Zhou F, Liu W M. Magnetite-loaded thermosensitive nanogels for bioinspired lubrication and multimodal friction control. ACS Macro Lett 5(1): 144–148 (2016)
Google Scholar
[25]
Liu G Q, Wang X L, Zhou F, Liu W M. Tuning the tribological property with thermal sensitive microgels for aqueous lubrication. ACS Appl Mater Interfaces 5(21): 10842–10852 (2013)
Google Scholar
[26]
Zhang Z Y, Moxey M, Alswieleh A, Morse A J, Lewis A L, Geoghegan M, Leggett G J. Effect of salt on phosphorylcholine-based zwitterionic polymer brushes. Langmuir 32(20): 5048–5057 (2016)
Google Scholar
[27]
Yu Y L, Vancso G J, de Beer S. Substantially enhanced stability against degrafting of zwitterionic PMPC brushes by utilizing PGMA-linked initiators. Eur Polym J 89: 221–229 (2017)
Google Scholar
[28]
Kobayashi M, Terayama Y, Hosaka N, Kaido M, Suzuki A, Yamada N, Torikai N, Ishihara K, Takahara A. Friction behavior of high-density poly(2-methacryloyloxyethyl phosphorylcholine) brush in aqueous media. Soft Matter 3(6): 740–746 (2007)
Google Scholar
[29]
Yu Y L, Yao Y C, van Lin S, de Beer S. Specific anion effects on the hydration and tribological properties of zwitterionic phosphorylcholine-based brushes. Eur Polym J 112: 222–227 (2019)
Google Scholar
[30]
Wang Y X, Sun Y L, Gu Y H, Zhang H Y. Articular cartilage-inspired surface functionalization for enhanced lubrication. Adv Mater Interfaces 6(12): 1900180 (2019)
Google Scholar
[31]
Zheng Y W, Yang J L, Liang J, Xu X Y, Cui W G, Deng L F, Zhang H Y. Bioinspired hyaluronic acid/phosphorylcholine polymer with enhanced lubrication and anti-inflammation. Biomacromolecules 20(11): 4135–4142 (2019)
Google Scholar
[32]
Chen H, Sun T, Yan Y F, Ji X L, Sun Y L, Zhao X, Qi J, Cui W G, Deng L F, Zhang H Y. Cartilage matrix-inspired biomimetic superlubricated nanospheres for treatment of osteoarthritis. Biomaterials 242: 119931 (2020)
Google Scholar
[33]
Klein J. Repair or replacement: A joint perspective. Science 323(5910): 47–48 (2009)
Google Scholar
[34]
Rong M M, Liu H, Scaraggi M, Bai Y Y, Bao L Y, Ma S H, Ma Z F, Cai M R, Dini D, Zhou F. High lubricity meets load capacity: Cartilage mimicking bilayer structure by brushing up stiff hydrogels from subsurface. Adv Funct Mater 30(39): 2004062 (2020)
Google Scholar
[35]
Wang D E, Gao X H, You S Q, Chen M, Ren L, Sun W J, Yang H, Xu H Y. Aptamer-functionalized polydiacetylene liposomes act as a fluorescent sensor for sensitive detection of MUC1 and targeted imaging of cancer cells. Sens Actuat B Chem 309: 127778 (2020)
Google Scholar
Friction
Volume 11 Issue 6,
June 2023
Pages 938-948
DOI: 10.1007/s40544-022-0634-5
Cite this article:
LIU G, FENG Y, GAO X, et al. Synovial fluid-inspired biomimetic lubricating microspheres: Zwitterionic polyelectrolyte brushes-grafted microgels. Friction, 2023, 11(6): 938-948. https://doi.org/10.1007/s40544-022-0634-5

632

Views

36

Downloads

5

Crossref

5

Web of Science

5

Scopus

0

CSCD

Altmetrics
Received: 07 January 2022
Revised: 13 February 2022
Accepted: 08 April 2022
Published: 15 August 2022
© The author(s) 2022.

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Return