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Research Article | Open Access

Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release

Xiaowei MAO1,2,†, Kexin CHEN3,†, Yanlong ZHAO2, Chunrong Xiong1, Jing LUO4, Yuguang WANG5( ), Bo WANG6( ), Hongyu ZHANG2( )
School of Chemical Engineering and Technology, Hainan University, Haikou 570228, China
State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China
Peking University School of Nursing & National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100191, China
Beijing Research Institute of Automation for Machinery Industry Co., Ltd., Beijing 100120, China
Center of Digital Dentistry, Peking University School and Hospital of Stomatology & NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing 100081, China
College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China

† Xiaowei MAO and Kexin CHEN contributed equally to this work.

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Abstract

Osteoarthritis is associated with the significantly increased friction of the joint, which results in progressive and irreversible damage to the articular cartilage. A synergistic therapy integrating lubrication enhancement and drug delivery is recently proposed for the treatment of early-stage osteoarthritis. In the present study, bioinspired by the self-adhesion performance of mussels and super-lubrication property of articular cartilages, a biomimetic self-adhesive dopamine methacrylamide–poly(2-methacryloyloxyethyl phosphorylcholine) (DMA–MPC) copolymer was designed and synthesized via free radical polymerization. The copolymer was successfully modified onto the surface of biodegradable mesoporous silica nanoparticles (bMSNs) by the dip-coating method to prepare the dual-functional nanoparticles (bMSNs@DMA–MPC), which were evaluated using a series of surface characterizations including the transmission electron microscope (TEM), Fourier transform infrared (FTIR) spectrum, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), etc. The tribological test and in vitro drug release test demonstrated that the developed nanoparticles were endowed with improved lubrication performance and achieved the sustained release of an anti-inflammatory drug, i.e., diclofenac sodium (DS). In addition, the in vitro biodegradation test showed that the nanoparticles were almost completely biodegraded within 10 d. Furthermore, the dual-functional nanoparticles were biocompatible and effectively reduced the expression levels of two inflammation factors such as interleukin-1β (IL-1β) and interleukin-6 (IL-6). In summary, the surface functionalized nanoparticles with improved lubrication and local drug release can be applied as a potential intra-articularly injected biolubricant for synergistic treatment of early-stage osteoarthritis.

Keywords

surface functionalizationphosphorylcholine coatingmesoporous silica nanoparticleshydration lubricationosteoarthritis

References

[1]
Klein J. Repair or replacement: A joint perspective. Science 323(5910): 47–48 (2009)
Crossref Google Scholar
[2]
Wang Y X, Sun Y L, Avestro A J, McGonigal P R, Zhang H Y. Supramolecular repair of hydration lubrication surfaces. Chem 8(2): 480–493 (2022)
Crossref Google Scholar
[3]
Morgese G, Trachsel L, Romio M, Divandari M, Ramakrishna S N, Benetti E M. Topological polymer chemistry enters surface science: Linear versus cyclic polymer brushes. Angew Chem Int Ed 55(50): 15583–15588 (2016)
Crossref Google Scholar
[4]
Morgese G, Cavalli E, Rosenboom J G, Zenobi-Wong M, Benetti E M. Cyclic polymer grafts that lubricate and protect damaged cartilage. Angew Chem Int Ed 57(6): 1621–1626 (2018)
Crossref Google Scholar
[5]
Xie R J, Yao H, Mao A S, Zhu Y, Qi D W, Jia Y G, Gao M, Chen Y H, Wang L, Wang D A, et al. Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis. Nat Biomed Eng 5(10): 1189–1201 (2021)
Crossref Google Scholar
[6]
Kosinska M K, Ludwig T E, Liebisch G, Zhang R Y, Siebert H C, Wilhelm J, Kaesser U, Dettmeyer R B, Klein H, Ishaque B, et al. Articular joint lubricants during osteoarthritis and rheumatoid arthritis display altered levels and molecular species. PLoS One 10(5): e0125192 (2015)
Crossref Google Scholar
[7]
Ludwig T E, McAllister J R, Lun V, Wiley J P, Schmidt T A. Diminished cartilage-lubricating ability of human osteoarthritic synovial fluid deficient in proteoglycan 4: Restoration through proteoglycan 4 supplementation. Arthritis Rheum 64(12): 3963–3971 (2012)
Crossref Google Scholar
[8]
Morgese G, Benetti E M, Zenobi-Wong M. Molecularly engineered biolubricants for articular cartilage. Adv Healthc Mater 7(16): 1701463 (2018)
Crossref Google Scholar
[9]
Poulet B, Staines K A. New developments in osteoarthritis and cartilage biology. Curr Opin Pharmacol 28: 8–13 (2016)
Crossref Google Scholar
[10]
Szychlinska M A, Leonardi R, Al-Qahtani M, Mobasheri A, Musumeci G. Altered joint tribology in osteoarthritis: Reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approaches. Ann Phys Rehabil Med 59(3): 149–156 (2016)
Crossref Google Scholar
[11]
Yan X, Yang B, Chen Y R, Song Y F, Ye J, Pan Y F, Zhou B N, Wang Y Q, Mao F B, Dong Y C, et al. Anti-friction MSCs delivery system improves the therapy for severe osteoarthritis. Adv Mater 33(52): 2104758 (2021)
Crossref Google Scholar
[12]
Kloppenburg M, Berenbaum F. Osteoarthritis year in review 2019: Epidemiology and therapy. Osteoarthr Cartil 28(3): 242–248 (2020)
Crossref Google Scholar
[13]
Sun T, Sun Y L, Zhang H Y. Phospholipid-coated mesoporous silica nanoparticles acting as lubricating drug nanocarriers. Polymers 10(5): 513 (2018)
Crossref Google Scholar
[14]
Jones G, Winzenberg T. Osteoarthritis: A new short-term treatment option? Lancet 394(10213): 1967–1968 (2019)
Crossref Google Scholar
[15]
Rothenfluh D A, Bermudez H, O’Neil C P, Hubbell J A. Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage. Nat Mater 7(3): 248–254 (2008)
Crossref Google Scholar
[16]
Jones I A, Togashi R, Wilson M L, Heckmann N, Vangsness C T Jr. Intra-articular treatment options for knee osteoarthritis. Nat Rev Rheumatol 15(2): 77–90 (2019)
Crossref Google Scholar
[17]
Chen H, Sun T, Yan Y F, Ji X L, Sun Y L, Zhao X, Qi J, Cui W G, Deng L F, Zhang H Y. Cartilage matrix-inspired biomimetic superlubricated nanospheres for treatment of osteoarthritis. Biomaterials 242: 119931 (2020)
Crossref Google Scholar
[18]
Lin W F, Klein J. Recent progress in cartilage lubrication. Adv Mater 33(18): 2005513 (2021)
Crossref Google Scholar
[19]
Liu G Q, Liu Z L, Li N, Wang X L, Zhou F, Liu W M. Hairy polyelectrolyte brushes-grafted thermosensitive microgels as artificial synovial fluid for simultaneous biomimetic lubrication and arthritis treatment. ACS Appl Mater Interfaces 6(22): 20452–20463 (2014)
Crossref Google Scholar
[20]
Morgese G, Cavalli E, Müller M, Zenobi-Wong M, Benetti E M. Nanoassemblies of tissue-reactive, polyoxazoline graft-copolymers restore the lubrication properties of degraded cartilage. ACS Nano 11(3): 2794–2804 (2017)
Crossref Google Scholar
[21]
Seror J, Merkher Y, Kampf N, Collinson L, Day A J, Maroudas A, Klein J. Normal and shear interactions between hyaluronan–aggrecan complexes mimicking possible boundary lubricants in articular cartilage in synovial joints. Biomacromolecules 13(11): 3823–3832 (2012)
Crossref Google Scholar
[22]
Klein J. Hydration lubrication. Friction 1(1): 1–23 (2013)
Crossref Google Scholar
[23]
Kankala R K, Han Y H, Na J, Lee C H, Sun Z Q, Wang S B, Kimura T, Ok Y S, Yamauchi Y, Chen A Z, et al. Nanoarchitectured structure and surface biofunctionality of mesoporous silica nanoparticles. Adv Mater 32(23): 1907035 (2020)
Crossref Google Scholar
[24]
Mora-Raimundo P, Lozano D, Benito M, Mulero F, Manzano M, Vallet-Regí M. Osteoporosis remission and new bone formation with mesoporous silica nanoparticles. Adv Sci 8(16): 2101107 (2021)
Crossref Google Scholar
[25]
Yu M H, Jambhrunkar S, Thorn P, Chen J Z, Gu W Y, Yu C Z. Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells. Nanoscale 5(1): 178–183 (2013)
Crossref Google Scholar
[26]
Zhang K, Yang J L, Sun Y L, He M R, Liang J, Luo J, Cui W G, Deng L F, Xu X Y, Wang B, et al. Thermo-sensitive dual-functional nanospheres with enhanced lubrication and drug delivery for the treatment of osteoarthritis. Chem Eur J 26(46): 10564–10574 (2020)
Crossref Google Scholar
[27]
Zheng Y W, Yang J L, Liang J, Xu X Y, Cui W G, Deng L F, Zhang H Y. Bioinspired hyaluronic acid/phosphorylcholine polymer with enhanced lubrication and anti-inflammation. Biomacromolecules 20(11): 4135–4142 (2019)
Crossref Google Scholar
[28]
Wan L, Wang Y, Tan X L, Sun Y L, Luo J, Zhang H Y. Biodegradable lubricating mesoporous silica nanoparticles for osteoarthritis therapy. Friction 10(1): 68–79 (2022)
Crossref Google Scholar
[29]
Tan X L, Sun Y L, Sun T, Zhang H Y. Mechanised lubricating silica nanoparticles for on-command cargo release on simulated surfaces of joint cavities. Chem Commun 55(18): 2593–2596 (2019)
Crossref Google Scholar
[30]
Ishihara K, Ito M, Fukazawa K, Inoue Y. Interface of phospholipid polymer grafting layers to analyze functions of immobilized oligopeptides involved in cell adhesion. ACS Biomater Sci Eng 6(7): 3984–3993 (2020)
Crossref Google Scholar
[31]
Yang J L, Han Y, Lin J W, Zhu Y, Wang F, Deng L F, Zhang H Y, Xu X Y, Cui W G. Ball-bearing-inspired polyampholyte-modified microspheres as bio-lubricants attenuate osteoarthritis. Small 16(44): 2004519 (2020)
Crossref Google Scholar
[32]
Lee H, Dellatore S M, Miller W M, Messersmith P B. Mussel-inspired surface chemistry for multifunctional coatings. Science 318(5849): 426–430 (2007)
Crossref Google Scholar
[33]
Han Y, Liu S Z, Sun Y L, Gu Y H, Zhang H Y. Bioinspired surface functionalization of titanium for enhanced lubrication and sustained drug release. Langmuir 35(20): 6735–6741 (2019)
Crossref Google Scholar
[34]
He Y, Xu L H, Feng X, Zhao Y P, Chen L. Dopamine-induced nonionic polymer coatings for significantly enhancing separation and antifouling properties of polymer membranes: Codeposition versus sequential deposition. J Membr Sci 539: 421–431 (2017)
Crossref Google Scholar
[35]
Shen D K, Yang J P, Li X M, Zhou L, Zhang R Y, Li W, Chen L, Wang R, Zhang F, Zhao D Y. Biphase stratification approach to three-dimensional dendritic biodegradable mesoporous silica nanospheres. Nano Lett 14(2): 923–932 (2014)
Crossref Google Scholar
[36]
Jiao Y Y, Liu S Z, Sun Y L, Yue W, Zhang H Y. Bioinspired surface functionalization of nanodiamonds for enhanced lubrication. Langmuir 34(41): 12436–12444 (2018)
Crossref Google Scholar
[37]
Zhao W W, Wang H, Wang H M, Han Y, Zheng Z B, Liu X D, Feng B, Zhang H Y. Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis. Nanoscale 13(13): 6394–6399 (2021)
Crossref Google Scholar
[38]
Guo S B, Yu B, Ahmed A, Cong H L, Shen Y Q. Synthesis of polyacrylonitrile/polytetrahydropyrimidine (PAN/PTHP) nanofibers with enhanced antibacterial and anti-viral activities for personal protective equipment. J Hazard Mater 424: 127602 (2022)
Crossref Google Scholar
[39]
Tong X, Zhang D C, Zhang X T, Su Y C, Shi Z M, Wang K, Lin J G, Li Y C, Lin J X, Wen C E. Microstructure, mechanical properties, biocompatibility, and in vitro corrosion and degradation behavior of a new Zn–5Ge alloy for biodegradable implant materials. Acta Biomater 82: 197–204 (2018)
Crossref Google Scholar
[40]
Zhao Y Y, Wei C F, Chen X, Liu J W, Yu Q Q, Liu Y N, Liu J. Drug delivery system based on near-infrared light-responsive molybdenum disulfide nanosheets controls the high-efficiency release of dexamethasone to inhibit inflammation and treat osteoarthritis. ACS Appl Mater Interfaces 11(12): 11587–11601 (2019)
Crossref Google Scholar
[41]
Yang L, Sun L Y, Zhang H, Bian F K, Zhao Y J. Ice-inspired lubricated drug delivery particles from microfluidic electrospray for osteoarthritis treatment. ACS Nano 15(12): 20600–20606 (2021)
Crossref Google Scholar
[42]
Zhao W W, Wang H, Han Y, Wang H M, Sun Y L, Zhang H Y. Dopamine/phosphorylcholine copolymer as an efficient joint lubricant and ROS scavenger for the treatment of osteoarthritis. ACS Appl Mater Interfaces 12(46): 51236–51248 (2020)
Crossref Google Scholar
[43]
Ma M, Huang Y, Chen H R, Jia X Q, Wang S G, Wang Z Z, Shi J L. Bi2S3-embedded mesoporous silica nanoparticles for efficient drug delivery and interstitial radiotherapy sensitization. Biomaterials 37: 447–455 (2015)
Crossref Google Scholar
[44]
Chatterjee S, Ohshio M, Yusa S-i, Ooya T. Controlled micelle formation and stable capture of hydrophobic drug by alkylated POSS methacrylate block copolymers. ACS Appl Polym Mater 1(8): 2108–2119 (2019)
Crossref Google Scholar
[45]
Chen Z W, Li Z H, Lin Y H, Yin M L, Ren J S, Qu X G. Bioresponsive hyaluronic acid-capped mesoporous silica nanoparticles for targeted drug delivery. Chem Eur J 19(5): 1778–1783 (2013)
Crossref Google Scholar
[46]
Xu X Y, Li H R, Li K, Zeng Q, Liu Y, Zeng Y, Chen D, Liang J M, Chen X L, Zhan Y H. A photo-triggered conjugation approach for attaching RGD ligands to biodegradable mesoporous silica nanoparticles for the tumor fluorescent imaging. Nanomed Nanotechnol Biol Med 19: 136–144 (2019)
Crossref Google Scholar
[47]
Vatankhah-Varnosfaderani M, Hu X B, Li Q X, Adelnia H, Ina M, Sheiko S S. Universal coatings based on zwitterionic–dopamine copolymer microgels. ACS Appl Mater Interfaces 10(24): 20869–20875 (2018)
Crossref Google Scholar
[48]
Niu J Q, Wang H H, Chen J, Chen X Q, Han X, Liu H L. Bio-inspired zwitterionic copolymers for antifouling surface and oil–water separation. Colloids Surf A Physicochem Eng Aspects 626: 127016 (2021)
Crossref Google Scholar
[49]
Varache M, Bezverkhyy I, Weber G, Saviot L, Chassagnon R, Baras F, Bouyer F. Loading of cisplatin into mesoporous silica nanoparticles: Effect of surface functionalization. Langmuir 35(27): 8984–8995 (2019)
Crossref Google Scholar
[50]
Yan Y F, Sun T, Zhang H B, Ji X L, Sun Y L, Zhao X, Deng L F, Qi J, Cui W G, Santos H A, et al. Euryale ferox seed-inspired superlubricated nanoparticles for treatment of osteoarthritis. Adv Funct Mater 29(4): 1807559 (2019)
Crossref Google Scholar
[51]
Liu S H, Zhao X, Tang J M, Han Y M, Lin Q K. Drug-eluting hydrophilic coating modification of intraocular lens via facile dopamine self-polymerization for posterior capsular opacification prevention. ACS Biomater Sci Eng 7(3): 1065–1073 (2021)
Crossref Google Scholar
[52]
Valle-Delgado J J, Johansson L S, Österberg M. Bioinspired lubricating films of cellulose nanofibrils and hyaluronic acid. Colloids Surf B Biointerfaces 138: 86–93 (2016)
Crossref Google Scholar
[53]
Mancipe Castro L M, Sequeira A, García A J, Guldberg R E. Articular cartilage- and synoviocyte-binding poly(ethylene glycol) nanocomposite microgels as intra-articular drug delivery vehicles for the treatment of osteoarthritis. ACS Biomater Sci Eng 6(9): 5084–5095 (2020)
Crossref Google Scholar
[54]
Martel-Pelletier J, Barr A J, Cicuttini F M, Conaghan P G, Cooper C, Goldring M B, Goldring S R, Jones G, Teichtahl A J, Pelletier J P. Osteoarthritis. Nat Rev Dis Primers 2: 16072 (2016)
Crossref Google Scholar
[55]
Nadarassan D, Loni A, Canham L T, Scoutaris N, Trivedi V, Douroumis D. Ultrahigh nanostructured drug payloads from degradable mesoporous silicon aerocrystals. Int J Pharm 607: 120840 (2021)
Crossref Google Scholar
[56]
Liu M, Xie Z K, Sun G, Chen L J, Qi D K, Zhang H W, Xiong J Y, Furey A, Rahman P, Lei G H, et al. Macrophage migration inhibitory factor may play a protective role in osteoarthritis. Arthritis Res Ther 23: 59 (2021)
Crossref Google Scholar
Friction
Volume 11 Issue 7,
July 2023
Pages 1194-1211
DOI: 10.1007/s40544-022-0648-z
Cite this article:
MAO X, CHEN K, ZHAO Y, et al. Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release. Friction, 2023, 11(7): 1194-1211. https://doi.org/10.1007/s40544-022-0648-z

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Received: 12 February 2022
Revised: 02 April 2022
Accepted: 08 May 2022
Published: 17 October 2022
© The author(s) 2022.

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