AI Chat Paper
Discover the SciOpen Platform and Achieve Your Research Goals with Ease.
Feeding behavior is the most fundamental behavior in C. elegans. Our previous results have dissected the central integration circuit for the regulation of feeding, which integrates opposing sensory inputs and regulates feeding behavior in a nonlinear manner. However, the peripheral integration that acts downstream of the central integration circuit to modulate feeding remains largely unknown. Here, we find that a Gαi/o-coupled tyramine receptor, TYRA-2, is involved in peripheral feeding suppression. TYRA-2 suppresses feeding behavior via the AIM interneurons, which receive tyramine/octopamine signals from RIM/RIC neurons in the central integration circuit. Our results reveal previously unidentified roles for the receptor TYRA-2 and the AIM interneurons in feeding regulation, providing a further understanding of how biogenic amines tyramine and octopamine regulate feeding behavior.
Alkema MJ, Hunter-Ensor M, Ringstad N, Horvitz HR, (2005) Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system.Neuron 46:247-260
Aurelio O, Hall DH, Hobert O, (2002) Immunoglobulin-domain proteins required for maintenance of ventral nerve cord organization.Science 295:686-690
Avery L, Horvitz HR, (1990) Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans.J Exp Zool 253(3):263-270
Bany IA, Dong MQ, Koelle MR, (2003) Genetic and cellular basis for acetylcholine inhibition of Caenorhabditis elegans egg-laying behavior.J Neurosci 23:8060-8069
Bargmann CI, Hartwieg E, Horvitz HR, (1993) Odorant-selective genes and neurons mediate olfaction in C. elegans.Cell 74(3):515-527
Barrios A, Ghosh R, Fang C, Emmons SW, Barr MM, (2012) PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans.Nat Neurosci 15:1675-1682
Bergamasco C, Bazzicalupo P, (2006) Chemical sensitivity in Caenorhabditis elegans.Cellular and molecular life sciences: CMLS 63:1510-1522
Brenner S, (1974) The genetics of Caenorhabditis elegans.Genetics 77:71-94
Chao MY, Komatsu H, Fukuto HS, Dionne HM, Hart AC, (2004) Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit.Proc Natl Acad Sci USA 101:15512-15517
Chen JJ, Wilkinson JR, (2012) The monoamine oxidase type B inhibitor rasagiline in the treatment of Parkinson disease: is tyramine a challenge? J Clin Pharmacol 52:620-628
Chow BY, Han X, Boyden ES, (2012) Genetically encoded molecular tools for light-driven silencing of targeted neurons.Prog Brain Res 196:49-61
Greer ER, Perez CL, Van Gilst MR, Lee BH, Ashrafi K, (2008) Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding.Cell Metab 8:118-131
Jones D, Candido EP, (1999) Feeding is inhibited by sublethal concentrations of toxicants and by heat stress in the nematodeCaenorhabditis elegans: relationship to the cellular stress response.J Exp Zool 284(2):147-157
Keane J, Avery L, (2003) Mechanosensory inputs influence Caenorhabditis elegans pharyngeal activity via ivermectin sensitivity genes.Genetics 164(1):153-162
Li Z, Li Y, Yi Y, Huang W, Yang S, Niu W, Zhang L, Xu Z, Qu A, Wu Z, Xu T, (2012) Dissecting a central flip-flop circuit that integrates contradictory sensory cues in C. elegans feeding regulation.Nat Commun 3:776
Mendel JE, Korswagen HC, Liu KS, Hajdu-Cronin YM, Simon MI, Plasterk RH, Sternberg PW, (1995) Participation of the protein Go in multiple aspects of behavior in C. elegans.Science 267:1652-1655
Nelson LS, Rosoff ML, Li C, (1998) Disruption of a neuropeptide gene, flp-1, causes multiple behavioral defects in Caenorhabditis elegans.Science 281:1686-1690
Rex E, Komuniecki RW, (2002) Characterization of a tyramine receptor from Caenorhabditis elegans.J Neurochem 82:1352-1359
Rex E, Hapiak V, Hobson R, Smith K, Xiao H, Komuniecki R, (2005) TYRA-2 (F01E11.5): a Caenorhabditis elegans tyramine receptor expressed in the MC and NSM pharyngeal neurons.J Neurochem 94:181-191
Ringstad N, Abe N, Horvitz HR, (2009) Ligand-gated chloride channels are receptors for biogenic amines inC. elegans.Science 325:96-100
Rogers CM, Franks Cj, Walker Rj, Burke JF, Holden-Dye L, (2001) Regulation of the pharynx of Caenorhabditis elegans by 5-HT, octopamine, and FMRFamide-like neuropeptides.J Neurobiol 49(3):235-244
Rumore MM, Roth M, Orfanos A, (2010) Dietary tyramine restriction for hospitalized patients on linezolid: an update.Nutr Clin Prac 25:265-269
Sawin ER, Ranganathan R, Horvitz HR, (2000) C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway.Neuron 26(3):619-631
Segalat L, Elkes DA, Kaplan JM, (1995) Modulation of serotonin-controlled behaviors by Go in Caenorhabditis elegans.Science 267:1648-1651
Serrano-Saiz E, Poole RJ, Felton T, Zhang F, De La Cruz ED, Hobert O, (2013) Modular control of glutamatergic neuronal identity in C. elegans by distinct homeodomain proteins.Cell 155:659-673
Sze JY, Victor M, Loer C, Shi Y, Ruvkun G, (2000) Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant.Nature 403(6769):560-564
Vidal-Gadea A, Topper S, Young L, Crisp A, Kressin L, Elbel E, Maples T, Brauner M, Erbguth K, Axelrod A, Gottschalk A, Siegel D, Pierce-Shimomura JT, (2011) Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin.Proc Nat Acad Sci USA 108:17504-17509
White JG, Southgate E, Thomson JN, Brenner S, (1986) The structure of the nervous system of the nematode Caenorhabditis elegans.Philos Trans R Soc B 314:1-340
Xu K, Lee F, Gao SJ, Chung JE, Yano H, Kurisawa M, (2013) Injectable hyaluronic acid-tyramine hydrogels incorporating interferon-alpha2a for liver cancer therapy.J Controll Release 166:203-210
Yoshida K, Hirotsu T, Tagawa T, Oda S, Wakabayashi T, Iino Y, Ishihara T, (2012) Odour concentration-dependent olfactory preference change in C. elegans.Nat commun 3:739
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
