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Research Article

Numerical assessment of ambient inhaled micron particle deposition in a human nasal cavity

Yidan Shang, Kiao Inthavong( )
School of Engineering, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia
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Abstract

Understanding the particle exposure characteristics in human respiratory airways plays important roles in assessing the therapeutic or toxic effects of inhaled particles. In this study, numerical modelling approach was used to investigate micron-sized particle deposition in an anatomically realistic human nasal cavity. Flow rate of 15 L/min representing typical normal breathing rate for an adult was adopted, and particles were passively released from the ambient air adjacent to the nostrils. Through introducing a surface mapping technique, the 3D nasal cavity was "unwrapped" into a 2D planar domain, which allows a complete visual coverage of the spatial particle deposition in the intricate nasal cavity. Furthermore, deposition enhancement factor was applied to extract regional deposition concentration intensity relative to background intensity of the whole nasal passage. Results show that micron particle exposure in the nasal cavity is closely associated with nasal anatomical shape, airflow dynamics, and particle inertia. Specifically, the main passage of the nasal cavity received high particle deposition dosage, especially for larger micron-sized particles due to increased particle inertia. The nasal vestibule exhibited limited particle filtration effect and most deposited particles in this region concentrated posteriorly.

Keywords

particle exposurenasal cavitysurface mappingdeposition enhancement factor

References

 
Asgharian, B., Price, O. T., Oldham, M., Chen, L. C., Saunders, E. L., Gordon, T., Mikheev, V. B., Minard, K. R., Teeguarden, J. G. 2014. Computational modeling of nanoscale and microscale particle deposition, retention and dosimetry in the mouse respiratory tract. Inhal Toxicol, 26: 829-842.
Crossref Google Scholar
 
Bai, R., Zhang, L. L., Liu, Y., Meng, L., Wang, L. M., Wu, Y., Li, W., Ge, C. C., Le Guyader, L., Chen, C. Y. 2010. Pulmonary responses to printer toner particles in mice after intratracheal instillation. Toxicol Lett, 199: 288-300.
Crossref Google Scholar
 
Cheng, K. H., Cheng, Y. S., Yeh, H. C., Guilmette, R. A., Simpson, S. Q., Yang, Y. H., Swift, D. L. 1996. In vivo measurements of nasal airway dimensions and ultrafine aerosol deposition in the human nasal and oral airways. J Aerosol Sci, 27: 785-801.
Crossref Google Scholar
 
Corley, R. A., Kabilan, S., Kuprat, A. P., Carson, J. P., Minard, K. R., Jacob, R. E., Timchalk, C., Glenny, R., Pipavath, S., Cox, T., Wallis, C. D., Larson, R. F., Fanucchi, M. V., Postlethwait, E. M., Einstein, D. R. 2012. Comparative computational modeling of airflows and vapor dosimetry in the respiratory tracts of rat, monkey, and human. Toxicol Sci, 128: 500-516.
Crossref Google Scholar
 
Dai, Y. T., Chang, C. P., Tu, L. J., Hsu, D. J. 2007. Development of a taiwanese head model for studying occupational particle exposure. Inhal Toxicol, 19: 383-392.
Crossref Google Scholar
 
Dastan, A., Abouali, O., Ahmadi, G. 2014. CFD simulation of total and regional fiber deposition in human nasal cavities. J Aerosol Sci, 69: 132-149.
Crossref Google Scholar
 
Dong, J. L., Ma, J. W., Shang, Y. D., Inthavong, K., Qiu, D. S., Tu, J. Y., Frank-Ito, D. 2018. Detailed nanoparticle exposure analysis among human nasal cavities with distinct vestibule phenotypes. J Aerosol Sci, 121: 54-65.
Crossref Google Scholar
 
Doorly, D. J., Taylor, D. J., Schroter, R. C. 2008. Mechanics of airflow in the human nasal airways. Resp Physiol Neurobi, 163: 100-110.
Crossref Google Scholar
 
Farhadi Ghalati, P., Keshavarzian, E., Abouali, O., Faramarzi, A., Tu, J. Y., Shakibafard, A. 2012. Numerical analysis of micro- and nano-particle deposition in a realistic human upper airway. Comput Biol Med, 42: 39-49.
Crossref Google Scholar
 
Ge, Q. J., Li, X. D., Inthavong, K., Tu, J. Y. 2013. Numerical study of the effects of human body heat on particle transport and inhalation in indoor environment. Build Environ, 59: 1-9.
Crossref Google Scholar
 
Ghahramani, E., Abouali, O., Emdad, H., Ahmadi, G. 2014. Numerical analysis of stochastic dispersion of micro-particles in turbulent flows in a realistic model of human nasal/upper airway. J Aerosol Sci, 67: 188-206.
Crossref Google Scholar
 
Golshahi, L., Noga, M. L., Thompson, R. B., Finlay, W. H. 2011. In vitro deposition measurement of inhaled micrometer-sized particles in extrathoracic airways of children and adolescents during nose breathing. J Aerosol Sci, 42: 474-488.
Crossref Google Scholar
 
Gross, E. A., Swenberg, J. A., Fields, S., Popp, J. A. 1982. Comparative morphometry of the nasal cavity in rats and mice. J Anat, 135: 83-88.
Google Scholar
 
Hsu, D. J., Chuang, M. H. 2012. In-vivo measurements of micrometer-sized particle deposition in the nasal cavities of taiwanese adults. Aerosol Sci Tech, 46: 631-638.
Crossref Google Scholar
 
Inthavong, K., Ge, Q. J., Li, X. D., Tu, J. Y. 2012. Detailed predictions of particle aspiration affected by respiratory inhalation and airflow. Atmos Environ, 62: 107-117.
Crossref Google Scholar
 
Inthavong, K., Ge, Q. J., Li, X. D., Tu, J. Y. 2013. Source and trajectories of inhaled particles from a surrounding environment and its deposition in the respiratory airway. Inhal Toxicol, 25: 280-291.
Crossref Google Scholar
 
Inthavong, K., Shang, Y. D., Tu, J. Y. 2014. Surface mapping for visualization of wall stresses during inhalation in a human nasal cavity. Resp Physiol Neurobi, 190: 54-61.
Crossref Google Scholar
 
Inthavong, K., Tu, J. Y., Ahmadi, G. 2009. Computational modelling of gas-particle flows with different particle morphology in the human nasal cavity. J Comput Multiphase Flows, 1: 57-82.
Crossref Google Scholar
 
Inthavong, K., Wen, J., Tian, Z. F., Tu, J. Y. 2008. Numerical study of fibre deposition in a human nasal cavity. J Aerosol Sci, 39: 253-265.
Crossref Google Scholar
 
Kelly, J. T., Asgharian, B., Kimbell, J. S., Wong, B. A. 2004. Particle deposition in human nasal airway replicas manufactured by different methods. Part I: Inertial regime particles. Aerosol Sci Tech, 38: 1063-1071.
Crossref Google Scholar
 
Kelly, J. T., Asgharian, B., Wong, B. A. 2005. Inertial particle deposition in a monkey nasal mold compared with that in human nasal replicas. Inhal Toxicol, 17: 823-830.
Crossref Google Scholar
 
Kimbell, J. S. 2006. Nasal dosimetry of inhaled gases and particles: Where do inhaled agents go in the nose? Toxicol Pathol, 34: 270-273.
Crossref Google Scholar
 
King Se, C. M., Inthavong, K., Tu, J. Y. 2010. Inhalability of micron particles through the nose and mouth. Inhal Toxicol, 22: 287-300.
Crossref Google Scholar
 
Naftali, S., Rosenfeld, M., Wolf, M., Elad, D. 2005. The air-conditioning capacity of the human nose. Ann Biomed Eng, 33: 545-553.
Crossref Google Scholar
 
Oberdörster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Kreyling, W., Cox, C. 2004. Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol, 16: 437-445.
Crossref Google Scholar
 
Oldham, M. J. 2000. Computational fluid dynamic predictions and experimental results for particle deposition in an airway model. Aerosol Sci Tech, 32: 61-71.
Crossref Google Scholar
 
Schroeter, J. D., Garcia, G. J. M., Kimbell, J. S. 2011. Effects of surface smoothness on inertial particle deposition in human nasal models. J Aerosol Sci, 42: 52-63.
Crossref Google Scholar
 
Schroeter, J. D., Kimbell, J. S., Asgharian, B. 2006. Analysis of particle deposition in the turbinate and olfactory regions using a human nasal computational fluid dynamics model. J Aerosol Med, 19: 301-313.
Crossref Google Scholar
 
Schroeter, J. D., Kimbell, J. S., Asgharian, B., Tewksbury, E. W., Singal, M. 2012. Computational fluid dynamics simulations of submicrometer and micrometer particle deposition in the nasal passages of a Sprague-Dawley rat. J Aerosol Sci, 43: 31-44.
Crossref Google Scholar
 
Schroeter, J. D., Tewksbury, E. W., Wong, B. A., Kimbell, J. S. 2015. Experimental measurements and computational predictions of regional particle deposition in a sectional nasal model. J Aerosol Med Pulm D, 28: 20-29.
Crossref Google Scholar
 
Shang, Y. D., Dong, J. L., Inthavong, K., Tu, J. Y. 2015a. Comparative numerical modeling of inhaled micron-sized particle deposition in human and rat nasal cavities. Inhal Toxicol, 27: 694-705.
Crossref Google Scholar
 
Shang, Y. D., Inthavong, K., Tu, J. Y. 2015b. Detailed micro-particle deposition patterns in the human nasal cavity influenced by the breathing zone. Comput Fluids, 114: 141-150.
Crossref Google Scholar
 
Tian, L., Shang, Y. D., Chen, R., Bai, R., Chen, C. Y., Inthavong, K., Tu, J. Y. 2019. Correlation of regional deposition dosage for inhaled nanoparticles in human and rat olfactory. Part Fibre Toxicol, 16: 6.
Crossref Google Scholar
 
Tian, L., Shang, Y. D., Chen, R., Bai, R., Chen, C. Y., Inthavong, K., Tu, J. Y. 2017a. A combined experimental and numerical study on upper airway dosimetry of inhaled nanoparticles from an electrical discharge machine shop. Part Fibre Toxicol, 14: 24.
Crossref Google Scholar
 
Tian, L., Shang, Y. D., Dong, J. L., Inthavong, K., Tu, J. Y. 2017b. Human nasal olfactory deposition of inhaled nanoparticles at low to moderate breathing rate. J Aerosol Sci, 113: 189-200.
Crossref Google Scholar
 
Xu, X. Y., Shang, Y. D., Tian, L., Weng, W. G., Tu, J. Y. 2018. A numerical study on firefighter nasal airway dosimetry of smoke particles from a realistic composite deck fire. J Aerosol Sci, 123: 91-104.
Crossref Google Scholar
Experimental and Computational Multiphase Flow
Volume 1 Issue 2,
June 2019
Pages 109-115
DOI: 10.1007/s42757-019-0015-0
Cite this article:
Shang Y, Inthavong K. Numerical assessment of ambient inhaled micron particle deposition in a human nasal cavity. Experimental and Computational Multiphase Flow, 2019, 1(2): 109-115. https://doi.org/10.1007/s42757-019-0015-0

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Received: 11 January 2019
Revised: 08 March 2019
Accepted: 10 March 2019
Published: 17 April 2019
© Tsinghua University Press 2019
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