AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Experimental and Computational Multiphase Flow Article
Article Link
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Review Article

Liquid-liquid flow through micro dimensional reactors: A review on hydrodynamics, mass transfer, and reaction kinetics

Pooja Jaiswal, Uttam Kumar, Koushik Guha Biswas( )
Department of Chemical Engineering & Engineering Science, Rajiv Gandhi Institute of Petroleum Technology, An Institute of National Importance, Jais, India
Show Author Information

Abstract

Liquid-liquid flow through compact geometries has been gaining importance in recent time. It is encountered in the pharmaceutical industry and fine chemicals industry where high throughput separation is required. The extraction and kinetic process for two-phase systems can be enhanced by working in micro dimensions due to the higher interfacial area. Liquid-liquid flow in miniature channels varies from macro channels due to the difference of forces that act along with the interface like the effect of inertia and gravity is less prominent as compared to surface tension forces. The current work presents a comprehensive review of liquid-liquid flow particularly in micro dimensions and focuses on flow visualization studies, mass transfer, and pressure drop investigations. The main uniqueness in this review work is that a comprehensive study dealing with transport processes in a microdomain is reported in a detailed fashion with all important findings which can be a base for the starting of experimental investigations in these micro dimensions. Micro dimensions are current techniques for process intensification which plays a very important role in any process industries. A detailed critical review has been included in the review which suggests that micro dimensions serve an effective tool for process intensification.

Keywords

slug flowmass transferflow patternhydrodynamicsmicro dimensions

References

 
Abdollahi, A., Norris, S. E., Sharma, R. N. 2020. Pressure drop and film thickness of liquid-liquid Taylor flow in square microchannels. Int J Heat Mass Tran, 156: 119802.
Crossref Google Scholar
 
Abdollahi, A., Sharma, R. N., Vatani, A. 2017. Fluid flow and heat transfer of liquid-liquid two phase flow in microchannels: A review. Int Commun Heat Mass, 84: 66-74.
Crossref Google Scholar
 
Ahmed-Omer, B., Brandt, J. C., Wirth, T. 2007. Advanced organic synthesis using microreactor technology. Org Biomol Chem, 5: 733-740.
Crossref Google Scholar
 
Aljbour, S., Yamada, H., Tagawa, T. 2009. Simultaneous reaction-separation in a microchannel reactor with the aid of a guideline structure. International Scholarly and Scientific Research & Innovation, 3: 267-270.
Crossref Google Scholar
 
Anna, S. L., Bontoux, N., Stone, H. A. 2003. Formation of dispersions using “flow focusing” in microchannels. Appl Phys Lett, 82: 364-366.
Crossref Google Scholar
 
Aoki, N., Tanigawa, S., Mae, K. 2011. A new index for precise design and advanced operation of mass transfer in slug flow. Chem Eng J, 167: 651-656.
Crossref Google Scholar
 
Arjun, A., Ajith, R. R., Kumar Ranjith, S. 2020. Mixing characterization of binary-coalesced droplets in microchannels using deep neural network. Biomicrofluidics, 14: 034111.
Crossref Google Scholar
 
Azimian Fereydani, A., Azizi, Z. 2018. Experimental study of extraction fraction and mass transfer coefficient in a microchannel using butyl acetate/acetic acid/water chemical system. J Therm Anal Calorim, 133: 945-950.
Crossref Google Scholar
 
Bai, Y., Gao, M., Wen, L., He, C., Chen, Y., Liu, C., Fu, X., Huang, S. 2018. Applications of microfluidics in quantitative biology. Biotechnol J, 13: 1700170.
Crossref Google Scholar
 
Bavière, R., Gamrat, G., Favre-Marinet, M., Le Person, S. 2006. Modeling of laminar flows in rough-wall microchannels. J Fluid Eng, 128: 734-741.
Crossref Google Scholar
 
Biswas, K. G., Das, G., Ray, S., Basu, J. K. 2015b. Mass transfer characteristics of liquid-liquid flow in small diameter conduits. Chem Eng Sci, 122: 652-661.
Crossref Google Scholar
 
Biswas, K. G., Das, G., Ray, S., Basu, J. K. 2015c. The use of bends for enhanced mass transfer during liquid-liquid flow through milli channels. Int J Heat Mass Tran, 84: 876-892.
Crossref Google Scholar
 
Biswas, K. G., Patra, R., Das, G., Ray, S., Basu, J. K. 2015a. Effect of flow orientation on liquid-liquid slug flow in a capillary tube. Chem Eng J, 262: 436-446.
Crossref Google Scholar
 
Boogar, R. S., Gheshlaghi, R., Mahdavi, M. A. 2013. The effects of viscosity, surface tension, and flow rate on gasoil-water flow pattern in microchannels. Korean J Chem Eng, 30: 45-49.
Crossref Google Scholar
 
Bringer, M. R., Gerdts, C. J., Song, H., Tice, J. D., Ismagilov, R. F. 2004. Microfluidic systems for chemical kinetics that rely on chaotic mixing in droplets. Phil Trans R Soc A, 362: 1087-1104.
Crossref Google Scholar
 
Burns, J. R., Ramshaw, C. 2001. The intensification of rapid reactions in multiphase systems using slug flow in capillaries. Lab Chip, 1: 10.
Crossref Google Scholar
 
Caballero-Díaz, E., Simonet, B., Valcárcel, M. 2013. Liquid-liquid extraction assisted by a carbon nanoparticles interface. Electrophoretic determination of atrazine in environmental samples. Analyst, 138: 5913.
Crossref Google Scholar
 
Cao, C., Xia, G., Holladay, J., Jones, E., Wang, Y. 2004. Kinetic studies of methanol steam reforming over Pd/ZnO catalyst using a microchannel reactor. Appl Catal A: Gen, 262: 19-29.
Crossref Google Scholar
 
Cao, Y., Li, J., Jin, Y., Luo, J., Chen, M., Wang, Y. 2019. Liquid-liquid two-phase flow patterns in a new helical microchannel device. Can J Chem Eng, 97: 3175-3184.
Crossref Google Scholar
 
Chen, R., Feng, H., Zhu, X., Liao, Q., Ye, D., Liu, J., Liu, M., Chen, G., Wang, K. 2018. Interaction of the Taylor flow behaviors and catalytic reaction inside a gas-liquid-solid microreactor under long-term operation. Chem Eng Sci, 175: 175-184.
Crossref Google Scholar
 
Cherlo, S. K. R., Kariveti, S., Pushpavanam, S. 2010. Experimental and numerical investigations of two-phase (liquid-liquid) flow behavior in rectangular microchannels. Ind Eng Chem Res, 49: 893-899.
Crossref Google Scholar
 
Chinaud, M., Roumpea, E. P., Angeli, P. 2015. Studies of plug formation in microchannel liquid-liquid flows using advanced particle image velocimetry techniques. Exp Therm Fluid Sci, 69: 99-110.
Crossref Google Scholar
 
Choi, C., Kim, M. 2011. Flow pattern based correlations of two-phase pressure drop in rectangular microchannels. Int J Heat Fluid Fl, 32: 1199-1207.
Crossref Google Scholar
 
Coleman, J. W., Garimella, S. 1999. Characterization of two-phase flow patterns in small diameter round and rectangular tubes. Int J Heat Mass Tran, 42: 2869-2881.
Crossref Google Scholar
 
Cook, S. 2005. Process intensification: Three case studies. Innovations in Pharmaceutical Technology, 17: 54-59.
Google Scholar
 
Darekar, M., Singh, K. K., Mukhopadhyay, S., Shenoy, K. T. 2017. Liquid-liquid two-phase flow patterns in Y-junction microchannels. Ind Eng Chem Res, 56: 12215-12226.
Crossref Google Scholar
 
Der, O., Bertola, V. 2020. An experimental investigation of oil-water flow in a serpentine channel. Int J Multiphase Flow, 129: 103327.
Crossref Google Scholar
 
Desir, P., Chen, T., Bracconi, M., Saha, B., Maestri, M., Vlachos, D. G. 2020. Experiments and computations of microfluidic liquid-liquid flow patterns. React Chem Eng, 5: 39-50.
Crossref Google Scholar
 
Dessimoz, A. L., Cavin, L., Renken, A., Kiwi-Minsker, L. 2008. Liquid-liquid two-phase flow patterns and mass transfer characteristics in rectangular glass microreactors. Chem Eng Sci, 63: 4035-4044.
Crossref Google Scholar
 
Dessimoz, A.-L., Raspail, P., Berguerand, C., Kiwi-Minsker, L. 2010. Quantitative criteria to define flow patterns in micro-capillaries. Chem Eng J, 160: 882-890.
Crossref Google Scholar
 
Di Miceli Raimondi, N., Prat, L., Gourdon, C., Cognet, P. 2008. Direct numerical simulations of mass transfer in square microchannels for liquid-liquid slug flow. Chem Eng Sci, 63: 5522-5530.
Crossref Google Scholar
 
Di Miceli Raimondi, N., Prat, L., Gourdon, C., Tasselli, J. 2014. Experiments of mass transfer with liquid-liquid slug flow in square microchannels. Chem Eng Sci, 105: 169-178.
Crossref Google Scholar
 
Dummann, G., Quittmann, U., Gröschel, L., Agar, D. W., Wörz, O., Morgenschweis, K. 2003. The capillary-microreactor: A new reactor concept for the intensification of heat and mass transfer in liquid-liquid reactions. Catal Today, 79-80: 433-439.
Crossref Google Scholar
 
Emran, M., Islam, M. A. 2014. Numerical investigation of flow dynamics and heat transfer characteristics in a microchannel heat sink. Procedia Eng, 90: 563-568.
Crossref Google Scholar
 
Ergu, O. B., Sara, O. N., Yapıcı, S., Arzutug, M. E. 2009. Pressure drop and point mass transfer in a rectangular microchannel. Int Commun Heat Mass, 36: 618-623.
Crossref Google Scholar
 
Fu, B. R., Pan, C. 2010. Simple channel geometry for enhancement of chemical reactions in microchannels. Ind Eng Chem Res, 49: 9413-9422.
Crossref Google Scholar
 
Ghaini, A., Kashid, M. N., Agar, D. W. 2010. Effective interfacial area for mass transfer in the liquid-liquid slug flow capillary microreactors. Chem Eng Process: Process Intensif, 49: 358-366.
Crossref Google Scholar
 
Ghaini, A., Mescher, A., Agar, D. W. 2011. Hydrodynamic studies of liquid-liquid slug flows in circular microchannels. Chem Eng Sci, 66: 1168-1178.
Crossref Google Scholar
 
Ghosh, S., Das, G., Das, P. K. 2011. Pressure drop analysis for liquid-liquid downflow through vertical pipe. J Fluid Eng, 133: 011202.
Crossref Google Scholar
 
Giri Nandagopal, M. S., Selvaraju, N. 2016. Prediction of liquid-liquid flow patterns in a Y-junction circular microchannel using advanced neural network techniques. Ind Eng Chem Res, 55: 11346-11362.
Crossref Google Scholar
 
Gruber, R., Melin, T. 2003. Radial mass-transfer enhancement in bubble-train flow. Int J Heat Mass Tran, 46: 2799-2808.
Crossref Google Scholar
 
Guo, R., Fu, T., Zhu, C., Ma, Y. 2020. Pressure drop model of gas-liquid flow with mass transfer in tree-typed microchannels. Chem Eng J, 397: 125340.
Crossref Google Scholar
 
Gupta, A., Kumar, R. 2010. Effect of geometry on droplet formation in the squeezing regime in a microfluidic T-junction. Microfluid Nanofluid, 8: 799-812.
Crossref Google Scholar
 
Gupta, R., Leung, S. S. Y., Manica, R., Fletcher, D. F., Haynes, B. S. 2013. Hydrodynamics of liquid-liquid Taylor flow in microchannels. Chem Eng Sci, 92: 180-189.
Crossref Google Scholar
 
Haase, S., Bauer, T., Graf, E. 2020. Gas-liquid flow regime prediction in minichannels: A dimensionless, universally applicable approach. Ind Eng Chem Res, 59: 3820-3838.
Crossref Google Scholar
 
Halder, R., Lawal, A., Damavarapu, R. 2007. Nitration of toluene in a microreactor. Catal Today, 125: 74-80.
Crossref Google Scholar
 
Harirchian, T., Garimella, S. V. 2010. A comprehensive flow regime map for microchannel flow boiling with quantitative transition criteria. Int J Heat Mass Tran, 53: 2694-2702.
Crossref Google Scholar
 
Hoffmann, M., Schlüter, M., Räbiger, N. 2006. Experimental investigation of liquid-liquid mixing in T-shaped micro-mixers using μ-LIF and μ-PIV. Chem Eng Sci, 61: 2968-2976.
Google Scholar
 
Hong, Z.-C., Zhen, C.-E., Yang, C.-Y. 2008. Fluid dynamics and heat transfer analysis of three dimensional microchannel flows with microstructures. Numer Heat Tr A: Appl, 54: 293-314.
Crossref Google Scholar
 
Hsieh, S.-S., Lin, C.-Y., Huang, C.-F., Tsai, H.-H. 2004. Liquid flow in a micro-channel. J Micromech Microeng, 14: 436-445.
Crossref Google Scholar
 
Hwang, C.-Y. J., Pal, R. 1997. Flow of two-phase oil/water mixtures through sudden expansions and contractions. Chem Eng J, 68: 157-163.
Crossref Google Scholar
 
Iles, A., Habgood, M., de Mello, A. J., Wootton, R. C. R. 2007. A Simple technique for microfluidic heterogeneous catalytic hydrogenation reactor fabrication. Catal Lett, 114: 71-74.
Crossref Google Scholar
 
Jana, A. K., Das, G., Das, P. K. 2006. Flow regime identification of two-phase liquid-liquid upflow through vertical pipe. Chem Eng Sci, 61: 1500-1515.
Crossref Google Scholar
 
Jovanović, J., Rebrov, E. V., Nijhuis, T. A. X., Hessel, V., Schouten, J. C. 2010. Phase-transfer catalysis in segmented flow in a microchannel: Fluidic control of selectivity and productivity. Ind Eng Chem Res, 49: 2681-2687.
Crossref Google Scholar
 
Jovanović, J., Zhou, W., Rebrov, E. V., Nijhuis, T. A., Hessel, V., Schouten, J. C. 2011. Liquid-liquid slug flow: Hydrodynamics and pressure drop. Chem Eng Sci, 66: 42-54.
Crossref Google Scholar
 
Judy, J., Maynes, D., Webb, B. W. 2002. Characterization of frictional pressure drop for liquid flows through microchannels. Int J Heat Mass Tran, 45: 3477-3489.
Crossref Google Scholar
 
Kashid, M. N., Agar, D. W. 2007. Hydrodynamics of liquid-liquid slug flow capillary microreactor: Flow regimes, slug size and pressure drop. Chem Eng J, 131: 1-13.
Crossref Google Scholar
 
Kashid, M. N., Harshe, Y. M., Agar, D. W. 2007. Liquid-liquid slug flow in a capillary: An alternative to suspended drop or film contactors. Ind Eng Chem Res, 46: 8420-8430.
Crossref Google Scholar
 
Kashid, M. N., Renken, A., Kiwi-Minsker, L. 2011. Influence of flow regime on mass transfer in different types of microchannels. Ind Eng Chem Res, 50: 6906-6914.
Crossref Google Scholar
 
Kashid, M., Kiwi-Minsker, L. 2011. Quantitative prediction of flow patterns in liquid-liquid flow in micro-capillaries. Chem Eng Process: Process Intensif, 50: 972-978.
Crossref Google Scholar
 
Kikutani, Y., Horiuchi, T., Uchiyama, K., Hisamoto, H., Tokeshi, M., Kitamori, T. 2002. Glass microchip with three-dimensional microchannel network for 2 × 2 parallel synthesis. Lab Chip, 2: 188-192.
Crossref Google Scholar
 
Kim, S. C., Clark, I. C., Shahi, P., Abate, A. R. 2018. Single-cell RT-PCR in microfluidic droplets with integrated chemical lysis. Anal Chem, 90: 1273-1279.
Crossref Google Scholar
 
Kiwi-Minsker, L., Renken, A. 2005. Microstructured reactors for catalytic reactions. Catal Today, 110: 2-14.
Crossref Google Scholar
 
Kohl, M. J., Abdel-Khalik, S. I., Jeter, S. M., Sadowski, D. L. 2005. An experimental investigation of microchannel flow with internal pressure measurements. Int J Heat Mass Tran, 48: 1518-1533.
Crossref Google Scholar
 
Kralj, J. G., Sahoo, H. R., Jensen, K. F. 2007. Integrated continuous microfluidic liquid-liquid extraction. Lab Chip, 7: 256-263.
Crossref Google Scholar
 
Kumar, U., Panda, D., Biswas, K. G. 2018. Non-lithographic copper-wire based fabrication of micro-fluidic reactors for biphasic flow applications. Chem Eng J, 344: 221-227.
Crossref Google Scholar
 
Lee, W. Y., Wong, M., Zohar, Y. 2002. Pressure loss in constriction microchannels. J Microelectromech S, 11: 236-244.
Crossref Google Scholar
 
Lee, W., Son, G. 2008. Bubble dynamics and heat transfer during nucleate boiling in a microchannel. Numer Heat Tr A: Appl, 53: 1074-1090.
Crossref Google Scholar
 
Li, X., Chen, X., Huang, Y., Zhang, X. 2019a. Effect of interface wettability on the flow characteristics of liquid in smooth microchannels. Acta Mech, 230: 2111-2123.
Crossref Google Scholar
 
Li, X., Wang, W., Zhang, P., Li, J., Chen, G. 2019b. Interactions between gas-liquid mass transfer and bubble behaviours. R Soc Open Sci, 6: 190136.
Crossref Google Scholar
 
Liu, D., Garimella, S. V. 2004. Investigation of liquid flow in microchannels. J Thermophys Heat Tr, 18: 65-72.
Crossref Google Scholar
 
Liu, H., Yao, C., Zhao, Y., Chen, G. 2017. Desorption of carbon dioxide from aqueous MDEA solution in a microchannel reactor. Chem Eng J, 307: 776-784.
Crossref Google Scholar
 
Liu, M., Zhu, X., Chen, R., Liao, Q., Feng, H., Li, L. 2016. Catalytic membrane microreactor with Pd/γ-Al2O3 coated PDMS film modified by dopamine for hydrogenation of nitrobenzene. Chem Eng J, 301: 35-41.
Crossref Google Scholar
 
Liu, R. H., Stremler, M. A., Sharp, K. V., Olsen, M. G., Santiago, J. G., Adrian, R. J., Aref, H., Beebe, D. J. 2000. Passive mixing in a three-dimensional serpentine microchannel. J Microelectromech S, 9: 190-197.
Crossref Google Scholar
 
Liu, Y., Wang, S. 2019. Distribution of gas-liquid two-phase slug flow in parallel micro-channels with different branch spacing. Int J Heat Mass Tran, 132: 606-617.
Crossref Google Scholar
 
Liu, Z. M., Pang, Y., Shen, F., Li, J., Fu, S. 2011. Effects of geometry on the liquid flow in microchannel. AIP Conf Proc, 1376: 619-622
Crossref Google Scholar
 
Lohokare, S. R., Bhusare, V. H., Joshi, J. B. 2015. Process intensification: A case study. Indian Chemical Engineer, 57: 202-218.
Crossref Google Scholar
 
Mondal, P., Ghosh, S., Das, G., Ray, S. 2010. Phase inversion and mass transfer during liquid-liquid dispersed flow through mini-channel. Chem Eng Process: Process Intensif, 49: 1051-1057.
Crossref Google Scholar
 
Naher, S., Orpen, D., Brabazon, D., Poulsen, C. R., Morshed, M. M. 2011. Effect of micro-channel geometry on fluid flow and mixing. Simul Model Pract Th, 19: 1088-1095.
Crossref Google Scholar
 
Ngo, T. L., Kato, Y., Nikitin, K., Ishizuka, T. 2007. Heat transfer and pressure drop correlations of microchannel heat exchangers with S-shaped and zigzag fins for carbon dioxide cycles. Exp Therm Fluid Sci, 32: 560-570.
Crossref Google Scholar
 
Oh, J.-T., Choi, K.-I., Chien, N.-B. 2015. Pressure drop and heat transfer during a two-phase flow vaporization of propane in horizontal smooth minichannels. In: Heat Transfer Studies and Applications. IntechOpen, DOI: 10.5772/60813.
 
Olivieri, G., Marzocchella, A., Salatino, P. 2003. Hydrodynamics and mass transfer in a lab-scale three-phase internal loop airlift. Chem Eng J, 96: 45-54.
Crossref Google Scholar
 
Ou, J., Perot, B., Rothstein, J. P. 2004. Laminar drag reduction in microchannels using ultrahydrophobic surfaces. Phys Fluids, 16: 4635-4643.
Crossref Google Scholar
 
Paul, K., Bhattacharjee, P. 2018. Mass transfer and hydrodynamic study of supercritical carbon dioxide extraction of 1, 8-cineole from small cardamom seeds. Chem Eng Commun, 205: 1023-1033.
Crossref Google Scholar
 
Pham, H., Wen, L., Zhang, H. 2012. Numerical simulation and analysis of gas-liquid flow in a T-junction microchannel. Adv Mech Eng, 4: 231675.
Crossref Google Scholar
 
Pietrzak, M. 2014. Flow patterns and volume fractions of phases during liquid-liquid two-phase flow in pipe bends. Exp Therm Fluid Sci, 54: 247-258.
Crossref Google Scholar
 
Qian, J., Li, X., Gao, Z., Jin, Z. 2019a. Mixing efficiency analysis on droplet formation process in microchannels by numerical methods. Processes, 7: 33.
Crossref Google Scholar
 
Qian, J., Li, X., Gao, Z., Jin, Z. 2019b. Mixing efficiency and pressure drop analysis of liquid-liquid two phases flow in serpentine microchannels. J Flow Chem, 9: 187-197.
Crossref Google Scholar
 
Qian, J., Li, X., Wu, Z., Jin, Z., Zhang, J., Sunden, B. 2019. Slug formation analysis of liquid-liquid two-phase flow in T-junction microchannels. J Thermal Sci Eng Appl, 11: 051017.
Crossref Google Scholar
 
Rai, A., Anand, M., Farooqui, S. A., Sibi, M. G., Sinha, A. K. 2018. Kinetics and computational fluid dynamics study for Fischer-Tropsch synthesis in microchannel and fixed-bed reactors. React Chem Eng, 3: 319-332.
Crossref Google Scholar
 
Raj, R., Mathur, N., Buwa, V. V. 2010. Numerical simulations of liquid-liquid flows in microchannels. Ind Eng Chem Res, 49: 10606-10614.
Crossref Google Scholar
 
Ramji, S., Rakesh, A., Pushpavanam, S. 2019. Modelling mass transfer in liquid-liquid slug flow in a microchannel. Chem Eng J, 364: 280-291.
Crossref Google Scholar
 
Rane, T. D., Chen, L., Zec, H. C., Wang, T. H. 2015. Microfluidic continuous flow digital loop-mediated isothermal amplification (LAMP). Lab Chip, 15: 776-782.
Crossref Google Scholar
 
Razaghi, R., Saidi, M. H. 2016. Experimental investigation of drag and lift forces on microparticles in low Reynolds number poiseuille flow in microchannel. J Disper Sci Technol, 37: 1767-1777.
Crossref Google Scholar
 
Renardy, Y., Joseph, D. D. 1985. Couette flow of two fluids between concentric cylinders. J Fluid Mech 150: 381-394.
Crossref Google Scholar
 
Rosen, A. M., Krylov, V. S. 1967. The scaling up of mass-transfer equipment and reactors: Use of hydraulic model experiments. Chem Eng Sci, 22: 407-416.
Crossref Google Scholar
 
Rouge, A., Spoetzl, B., Gebauer, K., Schenk, R., Renken, A. 2001. Microchannel reactors for fast periodic operation: the catalytic dehydration of isopropanol. Chem Eng Sci, 56: 1419-1427.
Crossref Google Scholar
 
Šalić, A., Tušek, A., Zelić, B. 2012. Application of microreactors in medicine and biomedicine. J Appl Biomed, 10: 137-153.
Crossref Google Scholar
 
Salim, A., Fourar, M., Pironon, J., Sausse J. 2008. Oil-water two-phase flow in microchannels: Flow patterns and pressure drop measurements. Can J Chem Eng, 86: 978-988.
Crossref Google Scholar
 
Sarkar, P. S., Singh, K. K., Shenoy, K. T., Sinha, A., Rao, H., Ghosh, S. K. 2012. Liquid-liquid two-phase flow patterns in a serpentine microchannel. Ind Eng Chem Res, 51: 5056-5066.
Crossref Google Scholar
 
Sattari-Najafabadi, M., Nasr Esfahany, M., Wu, Z., Sundén, B. 2017. The effect of the size of square microchannels on hydrodynamics and mass transfer during liquid-liquid slug flow. AIChE J, 63: 5019-5028.
Crossref Google Scholar
 
Serizawa, A., Feng, Z., Kawara, Z. 2002. Two-phase flow in microchannels. Exp Therm Fluid Sci, 26: 703-714.
Crossref Google Scholar
 
Shao, H., Lü, Y., Wang, K., Luo, G. 2012. An experimental study of liquid-liquid microflow pattern maps accompanied with mass transfer. Chin J Chem Eng, 20: 18-26.
Crossref Google Scholar
 
Shui, L., Eijkel, J. C. T., van den Berg, A. 2007. Multiphase flow in microfluidic systems—Control and applications of droplets and interfaces. Adv Colloid Interface Sci, 133: 35-49.
Crossref Google Scholar
 
Singh, K. K., Renjith, A. U., Shenoy, K. T. 2015. Liquid-liquid extraction in microchannels and conventional stage-wise extractors: A comparative study. Chem Eng Process: Process Intensif, 98: 95-105.
Crossref Google Scholar
 
Soboll, S., Kockmann, N. 2018. Hydrodynamics and mass transfer in a lab-scale stirred-pulsed extraction column. Chem Eng Tech, 41: 1847-1856.
Crossref Google Scholar
 
Su, Y., Chen, G., Zhao, Y., Yuan, Q. 2009. Intensification of liquid-liquid two-phase mass transfer by gas agitation in a microchannel. AIChE J, 55: 1948-1958.
Crossref Google Scholar
 
Su, Y., Zhao, Y., Chen, G., Yuan, Q. 2010. Liquid-liquid two-phase flow and mass transfer characteristics in packed microchannels. Chem Eng Sci, 65: 3947-3956.
Crossref Google Scholar
 
Suo, M., Griffith, P. 1964. Two-phase flow in capillary tubes. J Basic Eng, 86: 576-582.
Crossref Google Scholar
 
Talapuru, S., Eromo, A. C. 2013. Phase transfer catalysis in micro channels, milli channels and fine droplets column: Effective interfacial area. In: Proceedings of the AIChE Annual Meeting.
 
Thulasidas, T. C., Abraham, M. A., Cerro, R. L. 1997. Flow patterns in liquid slugs during bubble-train flow inside capillaries. Chem Eng Sci, 52: 2947-2962.
Crossref Google Scholar
 
Tsaoulidis, D., Angeli, P. 2015. Effect of channel size on mass transfer during liquid-liquid plug flow in small scale extractors. Chem Eng J, 262: 785-793.
Crossref Google Scholar
 
Ufer, A., Mendorf, M., Ghaini, A., Agar, D. W. 2011. Liquid/liquid slug flow capillary microreactor. Chem Eng Tech, 34: 353-360.
Crossref Google Scholar
 
Wang, T., Xu, C. 2020. Liquid-liquid-liquid three-phase microsystem: Hybrid slug flow-laminar flow. Lab Chip, 20: 1891-1897.
Crossref Google Scholar
 
Wang, X., Wang, Y., Li, F., Li, L., Ge, X., Zhang, S., Qiu, T. 2020. Scale-up of microreactor: Effects of hydrodynamic diameter on liquid-liquid flow and mass transfer. Chem Eng Sci, 226: 115838.
Crossref Google Scholar
 
Watts, P., Haswell, S. J. 2005. The application of micro reactors for organic synthesis. Chem Soc Rev, 34: 235.
Crossref Google Scholar
 
Weigl, B. H., Bardell, R. L., Kesler, N., Morris, C. J. 2001. Lab-on-a-chip sample preparation using laminar fluid diffusion interfaces— Computational fluid dynamics model results and fluidic verification experiments. Fresenius J Anal Chem, 371: 97-105.
Crossref Google Scholar
 
Woitalka, A., Kuhn, S., Jensen, K. F. 2014. Scalability of mass transfer in liquid-liquid flow. Chem Eng Sci, 116: 1-8.
Crossref Google Scholar
 
Wong, S. H., Bryant, P., Ward, M., Wharton, C. 2003. Investigation of mixing in a cross-shaped micromixer with static mixing elements for reaction kinetics studies. Sensor Actuat B: Chem, 95: 414-424.
Crossref Google Scholar
 
Wu, Z., Sundén, B. 2019. Liquid-liquid two-phase flow patterns in ultra-shallow straight and serpentine microchannels. Heat Mass Transfer, 55: 1095-1108.
Crossref Google Scholar
 
Xia, G. D., Jiang, J., Wang, J., Zhai, Y. L., Ma, D. D. 2015. Effects of different geometric structures on fluid flow and heat transfer performance in microchannel heat sinks. Int J Hea Mass Tran, 80: 439-447.
Crossref Google Scholar
 
Xu, J. H., Tan, J., Li, S. W., Luo, G. S. 2008. Enhancement of mass transfer performance of liquid-liquid system by droplet flow in microchannels. Chem Eng J, 141: 242-249.
Crossref Google Scholar
 
Yagodnitsyna, A. A., Kovalev, A. V., Bilsky, A. V. 2016. Flow patterns of immiscible liquid-liquid flow in a rectangular microchannel with T-junction. Chem Eng J , 303: 547-554.
Crossref Google Scholar
 
Yao, C., Ma, H., Zhao, Q., Liu, Y., Zhao, Y., Chen, G. 2020. Mass transfer in liquid-liquid Taylor flow in a microchannel: Local concentration distribution, mass transfer regime and the effect of fluid viscosity. Chem Eng Sci, 223: 115734.
Crossref Google Scholar
 
Yong, J. Q., Teo, C. J. 2014. Mixing and heat transfer enhancement in microchannels containing converging-diverging passages. J Heat Transfer, 136: 041704.
Crossref Google Scholar
 
Zhang, L., Liu, Z., Wang, Y., Xie, R., Ju, X., Wang, W., Lin, L., Chu, L. 2017. Facile immobilization of Ag nanoparticles on microchannel walls in microreactors for catalytic applications. Chem Eng J, 309: 691-699.
Crossref Google Scholar
 
Zhang, X., Chen, D., Wang, Y., Cai, W. 2012. Liquid-liquid two-phase flow patterns and mass transfer characteristics in a circular microchannel. Adv Mater Res, 482-484: 89-94.
Crossref Google Scholar
 
Zhang, X., Stefanick, S., Villani, F. J. 2004. Application of microreactor technology in process development. Org Proc Res Dev, 8: 455-460.
Crossref Google Scholar
 
Zhang, X., Zhao, T., Wu, S., Yao, F. 2019. Experimental study on liquid flow and heat transfer in rough microchannels. Adv Cond Matter Phys, 2019: 1-9.
Crossref Google Scholar
 
Zhang, Y. 2018. On study of application of micro-reactor in chemistry and chemical field. IOP Conf Ser: Earth Environ Sci, 113: 012003.
Crossref Google Scholar
 
Zhang, Y., Jiang, H.-R. 2016. A review on continuous-flow microfluidic PCR in droplets: Advances, challenges and future. Anal Chimica Acta, 914: 7-16.
Crossref Google Scholar
 
Zhao, Y., Chen, G., Yuan, Q. 2006. Liquid-liquid two-phase flow patterns in a rectangular microchannel. AIChE J, 52: 4052-4060.
Crossref Google Scholar
 
Zhao, Y., Chen, G., Yuan, Q. 2007. Liquid-liquid two-phase mass transfer in the T-junction microchannels. AIChE J, 53: 3042-3053.
Crossref Google Scholar
Experimental and Computational Multiphase Flow
Volume 4 Issue 3,
September 2022
Pages 193-211
DOI: 10.1007/s42757-020-0092-0
Cite this article:
Jaiswal P, Kumar U, Biswas KG. Liquid-liquid flow through micro dimensional reactors: A review on hydrodynamics, mass transfer, and reaction kinetics. Experimental and Computational Multiphase Flow, 2022, 4(3): 193-211. https://doi.org/10.1007/s42757-020-0092-0

786

Views

7

Crossref

10

Web of Science

9

Scopus

Altmetrics
Received: 22 May 2020
Revised: 26 September 2020
Accepted: 22 October 2020
Published: 19 January 2021
© Tsinghua University Press 2020
Return