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Review Article

Does Normobaric Hypoxic Resistance Training Confer Benefit over Normoxic Training in Athletes? A Narrative Review

Institute of Neuroscience, UCLouvain, Louvain-la-Neuve, Belgium
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Abstract

Purpose

The aim of the present review was to focus on normobaric hypoxic resistance training and to discuss to what extent this method can be efficient for athletes to potentiate classical adaptations to resistance training and thereby performance.

Methods

Search terms related to the topic of the present review such as normobar*, hypox*, resistance exercise, resistance training and performance were inserted in Pubmed and Scopus. In total, 16 articles made the core of this narrative review.

Results

Based on the available literature, 2–3 sessions a week performed in hypoxic conditions for 4–6 weeks with a FiO2 of 0.14–0.15 should recommended to athletes looking at potentiating the effects of resistance training. A large range of loads has been found to be efficient at inducing physiological effects in hypoxic vs normoxic conditions, from 20% to 90% of the 1-RM. Ideally, at least the last set should be performed to failure, if not all. Also, inter-set rest periods should be around 30 s for low-load exercise (30%–40% 1-RM), around 60 s for moderate-load exercise (60%–70% 1-RM) and 2 min for high-load exercise (85%–90% 1-RM).

Conclusion

While there is no one size fits all and certainly no guarantee of added value over normoxic training, each athlete looking at potentiating the effects of resistance training should try to implement some sessions in hypoxic conditions. Based on the individual response, subtle improvements may be expected on muscle strength and mass, velocity and power, as well as hormonal responses to resistance training.

References

1

Bandy WD, Lovelace-Chandler V, McKitrick-Bandy B. Adaptation of skeletal muscle to resistance training. J Orthop Sports Phys Ther. 1990;12(6):248–55. https://doi.org/10.2519/jospt.1990.12.6.248.

2

Chapman RF, Stray-Gundersen J, Levine BD. Individual variation in response to altitude training. J Appl Physiol. 1998;85(4):1448–56. https://doi.org/10.1152/jappl.1998.85.4.1448.

3

Chycki J, Czuba M, Golas A, Zajac A, Fidos-Czuba O, Mlynarz A, Smolka W. Neuroendocrine responses and body composition changes following resistance training under normobaric hypoxia. J Hum Kinet. 2016;53:91–8. https://doi.org/10.1515/hukin-2016-0013.

4

Clancy RB, Herring MP, MacIntyre TE, Campbell MJ. A review of competitive sport motivation research. Psychol Sport Exerc. 2016;27:232–42. https://doi.org/10.1016/j.psychsport.2016.09.003.

5

D’Hulst G, Deldicque L. Human skeletal muscle wasting in hypoxia: a matter of hypoxic dose? J Appl Physiol. 2017;122(2):406–8. https://doi.org/10.1152/japplphysiol.00264.2016.

6

D’Hulst G, Jamart C, Van Thienen R, Hespel P, Francaux M, Deldicque L. Effect of acute environmental hypoxia on protein metabolism in human skeletal muscle. Acta Physiol. 2013;208(3):251–64. https://doi.org/10.1111/apha.12086.

7

van Doorslaer de Ten Ryen S, Warnier G, Gnimassou O, Belhaj MR, Benoit N, Naslain D, Brook MS, Smith K, Wilkinson DJ, Nielens H, Atherton PJ, Francaux M, Deldicque L. Higher strength gain after hypoxic vs normoxic resistance training despite no changes in muscle thickness and fractional protein synthetic rate. FASEB J. 2021;35(8):e21773. https://doi.org/10.1096/fj.202100654RR.

8

Feriche B, Garcia-Ramos A, Morales-Artacho AJ, Padial P. Resistance training using different hypoxic training strategies: a basis for hypertrophy and muscle power development. Sports Med Open. 2017;3(1):12. https://doi.org/10.1186/s40798-017-0078-z.

9

Friedmann B, Kinscherf R, Borisch S, Richter G, Bartsch P, Billeter R. Effects of low-resistance/high-repetition strength training in hypoxia on muscle structure and gene expression. Pflugers Arch. 2003;446(6):742–51. https://doi.org/10.1007/s00424-003-1133-9.

10

Garvican-Lewis LA, Sharpe K, Gore CJ. Time for a new metric for hypoxic dose? J Appl Physiol. 2016;121(1):352–5. https://doi.org/10.1152/japplphysiol.00579.2015.

11

Gharahdaghi N, Phillips BE, Szewczyk NJ, Smith K, Wilkinson DJ, Atherton PJ. Links between testosterone, oestrogen, and the growth hormone/insulin-like growth factor axis and resistance exercise muscle adaptations. Front Physiol. 2020;11:621226. https://doi.org/10.3389/fphys.2020.621226.

12

Girard O, Brocherie F, Goods PSR, Millet GP. An updated panorama of “living low-training high” altitude/hypoxic methods. Front Sports Act Living. 2020;2:26. https://doi.org/10.3389/fspor.2020.00026.

13

Gnimassou O, Fernandez-Verdejo R, Brook M, Naslain D, Balan E, Sayda M, Cegielski J, Nielens H, Decottignies A, Demoulin JB, Smith K, Atherton PJ, Francaux M, Deldicque L. Environmental hypoxia favors myoblast differentiation and fast phenotype but blunts activation of protein synthesis after resistance exercise in human skeletal muscle. FASEB J. 2018;32(10):5272–84. https://doi.org/10.1096/fj.201800049RR.

14

Gordon SE, Kraemer WJ, Vos NH, Lynch JM, Knuttgen HG. Effect of acid-base balance on the growth hormone response to acute high-intensity cycle exercise. J Appl Physiol. 1994;76(2):821–9. https://doi.org/10.1152/jappl.1994.76.2.821.

15

Ho JY, Kuo TY, Liu KL, Dong XY, Tung K. Combining normobaric hypoxia with short-term resistance training has no additive beneficial effect on muscular performance and body composition. J Strength Cond Res. 2014;28(4):935–41. https://doi.org/10.1519/JSC.0000000000000289.

16

Hubal MJ, Gordish-Dressman H, Thompson PD, Price TB, Hoffman EP, Angelopoulos TJ, Gordon PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Seip RL, Clarkson PM. Variability in muscle size and strength gain after unilateral resistance training. Med Sci Sports Exerc. 2005;37(6):964–72.

17

Inness MW, Billaut F, Walker EJ, Petersen AC, Sweeting AJ, Aughey RJ. Heavy resistance training in hypoxia enhances 1RM squat performance. Front Physiol. 2016;7:502. https://doi.org/10.3389/fphys.2016.00502.

18

Jung WS, Kim SW, Kim JW, Park HY. Resistance training in hypoxia as a new therapeutic modality for sarcopenia—a narrative review. Life. 2021;11(2):106. https://doi.org/10.3390/life11020106.

19

Kon M, Ohiwa N, Honda A, Matsubayashi T, Ikeda T, Akimoto T, Suzuki Y, Hirano Y, Russell AP. Effects of systemic hypoxia on human muscular adaptations to resistance exercise training. Physiol Rep. 2014;2(6):e12033. https://doi.org/10.14814/phy2.12033.

20

Kurobe K, Huang Z, Nishiwaki M, Yamamoto M, Kanehisa H, Ogita F. Effects of resistance training under hypoxic conditions on muscle hypertrophy and strength. Clin Physiol Funct Imaging. 2015;35(3):197–202. https://doi.org/10.1111/cpf.12147.

21

Lee P, Chandel NS, Simon MC. Cellular adaptation to hypoxia through hypoxia inducible factors and beyond. Nat Rev Mol Cell Biol. 2020;21(5):268–83. https://doi.org/10.1038/s41580-020-0227-y.

22

Lockhart C, Scott BR, Thoseby B, Dascombe BJ. Acute effects of interset rest duration on physiological and perceptual responses to resistance exercise in hypoxia. J Strength Cond Res. 2020;34(8):2241–9. https://doi.org/10.1519/JSC.0000000000002755.

23

Manimmanakorn A, Manimmanakorn N, Taylor R, Draper N, Billaut F, Shearman JP, Hamlin MJ. Effects of resistance training combined with vascular occlusion or hypoxia on neuromuscular function in athletes. Eur J Appl Physiol. 2013;113(7):1767–74. https://doi.org/10.1007/s00421-013-2605-z.

24

Martinez-Guardado I, Ramos-Campo DJ, Olcina GJ, Rubio-Arias JA, Chung LH, Marin-Cascales E, Alcaraz PE, Timon R. Effects of high-intensity resistance circuit-based training in hypoxia on body composition and strength performance. Eur J Sport Sci. 2019;19(7):941–51. https://doi.org/10.1080/17461391.2018.1564796.

25

Martinez-Guardado IM, Urena BS, Cardenosa AC, Cardenosa MC, Camacho GO, Andrada RT. Effects of strength training under hypoxic conditions on muscle performance, body composition and haematological variables. Biol Sport. 2020;37(2):121–9. https://doi.org/10.5114/biolsport.2020.93037.

26

Mayo B, Miles C, Sims S, Driller M. The effect of resistance training in a hypoxic chamber on physical performance in elite rugby athletes. High Alt Med Biol. 2018;19(1):28–34. https://doi.org/10.1089/ham.2017.0099.

27

Millet GP, Faiss R, Pialoux V. Evidence for differences between hypobaric and normobaric hypoxia is conclusive. Exerc Sport Sci Rev. 2013;41(2):133. https://doi.org/10.1097/JES.0b013e318271a5e1.

28

Millet GP, Roels B, Schmitt L, Woorons X, Richalet JP. Combining hypoxic methods for peak performance. Sports Med. 2010;40(1):1–25. https://doi.org/10.2165/11317920-000000000-00000.

29

Namboonlue C, Hamlin MJ, Patpiya S, Manimmanakorn N, Wonnabussapawich P, Thuwakum W, Sumethanurakkhakun W, Manimmanakorn A. Optimal degree of hypoxia combined with low-load resistance training for muscle strength and thickness in athletes. J Phys Educ Sport. 2020;20(2):828–38. https://doi.org/10.7752/jpes.2020.02119.

30

Nishimura A, Sugita M, Kato K, Fukuda A, Sudo A, Uchida A. Hypoxia increases muscle hypertrophy induced by resistance training. Int J Sports Physiol Perform. 2010;5(4):497–508. https://doi.org/10.1123/ijspp.5.4.497.

31

Patterson SD, Hughes L, Warmington S, Burr J, Scott BR, Owens J, Abe T, Nielsen JL, Libardi CA, Laurentino G, Neto GR, Brandner C, Martin-Hernandez J, Loenneke J. Blood flow restriction exercise: considerations of methodology, application, and safety. Front Physiol. 2019;10:533. https://doi.org/10.3389/fphys.2019.00533.

32

Ramos-Campo DJ, Martinez-Guardado I, Olcina G, Marin-Pagan C, Martinez-Noguera FJ, Carlos-Vivas J, Alcaraz PE, Rubio JA. Effect of high-intensity resistance circuit-based training in hypoxia on aerobic performance and repeat sprint ability. Scand J Med Sci Sports. 2018;28(10):2135–43. https://doi.org/10.1111/sms.13223.

33

Richardson RS, Newcomer SC, Noyszewski EA. Skeletal muscle intracellular PO(2) assessed by myoglobin desaturation: response to graded exercise. J Appl Physiol. 2001;91(6):2679–85. https://doi.org/10.1152/jappl.2001.91.6.2679.

34

Schoenfeld BJ. Potential mechanisms for a role of metabolic stress in hypertrophic adaptations to resistance training. Sports Med. 2013;43(3):179–94. https://doi.org/10.1007/s40279-013-0017-1.

35

Schoenfeld BJ, Grgic J, Van Every DW, Plotkin DL. Loading recommendations for muscle strength, hypertrophy, and local endurance: a re-examination of the repetition continuum. Sports. 2021;9(2):32. https://doi.org/10.3390/sports9020032.

36

Scott BR, Loenneke JP, Slattery KM, Dascombe BJ. Blood flow restricted exercise for athletes: a review of available evidence. J Sci Med Sport. 2016;19(5):360–7. https://doi.org/10.1016/j.jsams.2015.04.014.

37

Scott BR, Slattery KM, Dascombe BJ. Intermittent hypoxic resistance training: does it provide added benefit? Front Physiol. 2014;5:397. https://doi.org/10.3389/fphys.2014.00397.

38

Scott BR, Slattery KM, Dascombe BJ. Intermittent hypoxic resistance training: is metabolic stress the key moderator? Med Hypotheses. 2015;84(2):145–9. https://doi.org/10.1016/j.mehy.2014.12.001.

39

Scott BR, Slattery KM, Sculley DV, Hodson JA, Dascombe BJ. Physical performance during high-intensity resistance exercise in normoxic and hypoxic conditions. J Strength Cond Res. 2015;29(3):807–15. https://doi.org/10.1519/JSC.0000000000000680.

40

Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003;3(10):721–32. https://doi.org/10.1038/nrc1187.

41

Soo J, Girard O, Ihsan M, Fairchild T. The use of the SpO2 to FiO2 ratio to individualize the hypoxic dose in sport science, exercise, and health settings. Front Physiol. 2020;11: 570472. https://doi.org/10.3389/fphys.2020.570472.

42

Törpel A, Peter B, Schega L. Effect of resistance training under normobaric hypoxia on physical performance, hematological parameters, and body composition in young and older people. Front Physiol. 2020;11:335. https://doi.org/10.3389/fphys.2020.00335.

43
Vincent KR, Vincent HK, Seto CK. Basic principles of exercise training and conditioning. Philadelphia (PA): Wolters Kluwer; 2013. pp. 60–62.
44

Wilber RL, Stray-Gundersen J, Levine BD. Effect of hypoxic “dose” on physiological responses and sea-level performance. Med Sci Sports Exerc. 2007;39(9):1590–9. https://doi.org/10.1249/mss.0b013e3180de49bd.

45

Yan B, Lai X, Yi L, Wang Y, Hu Y. Effects of five-week resistance training in hypoxia on hormones and muscle strength. J Strength Cond Res. 2016;30(1):184–93. https://doi.org/10.1519/JSC.0000000000001056.

Journal of Science in Sport and Exercise
Pages 306-314
Cite this article:
Deldicque L. Does Normobaric Hypoxic Resistance Training Confer Benefit over Normoxic Training in Athletes? A Narrative Review. Journal of Science in Sport and Exercise, 2022, 4(4): 306-314. https://doi.org/10.1007/s42978-021-00159-5

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Received: 14 September 2021
Accepted: 12 December 2021
Published: 25 February 2022
© Beijing Sport University 2022
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