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Research Article | Open Access

Antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1

Sayed A. El-Toumya, Josline Y. Saliba( ), Walaa A. El-Kashakb, Christel Martyc, Gilles Bedouxc, Nathalie Bourgougnonc
Chemistry of Tannins Department, National Research Centre, Dokki, 12622 Cairo, Egypt
Chemistry of Natural Compounds Department, National Research Centre, Dokki, 12622 Cairo, Egypt
Centre de Recherché et d’enseignement Yves Coppens, Campus de Tohannic, BP 573, 56017 Vannes, France

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

Evaluation of the anti-herpetic activity of 25 Egyptian plants extracts was investigated in vitro in this study. The antiviral activity against Herpes Simplex Virus type 1 (HSV-1) was done on Vero cell lines by cell viability. Only two plants extracts; namely Euphorbia coopire (Euphorbiaceae) and Morus alba (Moraceae) showed potent anti-herpetic activity and six other extracts showed moderate inhibition. In contrast, a bioassay monitored phytochemical exploration of these two plants led to the isolation of pure flavonoid compounds. The antiviral activity of the isolated compounds was also examined, among which seven pure compounds namely; 7-galloyl catechin, gallic acid, kaempferol 3-O-β-(6″-O-galloyl)-glucopyranoside, quercetin 3-O-β-(6″-O-galloyl)-glucopyranoside, curcumin, quercetin and kaempferol exhibited significant inhibition.

Keywords

PolyphenolsEgyptian plantsAnti-HSV-1Vero cell

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Food Science and Human Wellness
Volume 7 Issue 1,
March 2018
Pages 91-101
DOI: 10.1016/j.fshw.2018.01.001
Cite this article:
El-Toumy SA, Salib JY, El-Kashak WA, et al. Antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1. Food Science and Human Wellness, 2018, 7(1): 91-101. https://doi.org/10.1016/j.fshw.2018.01.001

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Received: 08 December 2016
Revised: 23 August 2017
Accepted: 15 January 2018
Published: 15 February 2018
© 2018 “Society information”.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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