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Research Article | Open Access

Prophylactic effect of Kudingcha polyphenols on oxazolone induced colitis through its antioxidant capacities

Xingyao Longa,b, Yanni Pana,c, Xin Zhaoa,c( )
Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, PR China
College of Food Science, Southwest University, Chongqing 400715, PR China
School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, PR China
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Abstract

This research the preventive effect of Kudingcha polyphenols (Kp) on colitis based on animal experiments. Experimental mice divided into four groups, including normal group, model group, low-concentration Kp (LKP) group and high-concentration Kp (HKP) group, and they all smeared and given 0.15mL 1% oxazolone solution by lavage to induce BALB/c mice colitis. DAI, colon weight/length ratio, serum levels of cytokines, related antioxidant activities of colon tissues such, and the mRNA expressions. The experimental results show that KP can significantly (p < 0.05) reduce DAI in mice with colitis and inhibit shortening of colon caused by colitis, increase colon weight/length ratio. It can also significantly reduce (p < 0.05) the activities of MPO, NO, MDA in mice colon tissues with colitis, increase the activity of GSH, and significantly increase (p < 0.05) the level of IL-2 and decrease the level of IL-10 in mice serum with colitis. The results of qPCR assay show that Kp can significantly increase (p < 0.05) the expression of Cu/Zn-SOD, Mn-SOD, GSH-Px, CAT, c-Kit, SCF and decrease the expression of IL-8, CXCR2 in mice colon tissues with colitis. Kp has a good preventive effect on colitis, and high concentration of PT has better preventive effect.

Keywords

AntioxidantColitisKudingcha polyphenolsOxazolonemRNA expression

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Food Science and Human Wellness
Volume 7 Issue 3,
September 2018
Pages 209-214
DOI: 10.1016/j.fshw.2018.06.002
Cite this article:
Long X, Pan Y, Zhao X. Prophylactic effect of Kudingcha polyphenols on oxazolone induced colitis through its antioxidant capacities. Food Science and Human Wellness, 2018, 7(3): 209-214. https://doi.org/10.1016/j.fshw.2018.06.002

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Received: 19 December 2017
Revised: 21 March 2018
Accepted: 13 June 2018
Published: 13 June 2018
© 2018 “Society information”.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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