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Short Communication | Open Access

Procoagulant constituents from Cordyceps militaris

Juanjuan Zhanga,1, Wei Zhanga,1, Zhenhua Yina, Changqin Lib( ), Wenyi Kanga,b( )
Huanghe Science and Technology College, Zhengzhou Key Laboratory of Medicinal Research, Zhengzhou, 450063, China
Institute of Chinese Materia Medica, Henan University, Kaifeng, 475004, China

1 These authors contributed equally to this work.

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

Cordyceps militaris, belongs to Clavicipitaceae family, was investigated for its chemical compounds, and six compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20 and recrystallization, and their structures were elucidated by spectral techniques and physicochemical properties as ergosterol (1), adenosine (2), cordycepin (3), ergosterol peroxide (4), tetracosanoic acid 2,3-dihydroxypropylester (5), mannitol (6). Procoagulant activity was screened by assaying the activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and fibrinogen (FIB) in vitro. The results indicated that ergosterol, adenosine, cordycepin, ergosterol peroxide and mannitol showed strong procoagulant activity.

Keywords

Procoagulant activityChemical componentErgosterolCordyceps militaris

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Food Science and Human Wellness
Volume 7 Issue 4,
December 2018
Pages 282-286
DOI: 10.1016/j.fshw.2018.11.001
Cite this article:
Zhang J, Zhang W, Yin Z, et al. Procoagulant constituents from Cordyceps militaris. Food Science and Human Wellness, 2018, 7(4): 282-286. https://doi.org/10.1016/j.fshw.2018.11.001

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Received: 25 September 2018
Accepted: 20 November 2018
Published: 24 November 2018
© 2018 “Society information”.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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