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Review Article | Open Access

Cytochrome P450 monooxygenase-mediated eicosanoid pathway: A potential mechanistic linkage between dietary fatty acid consumption and colon cancer risk

Weicang Wanga, Jianan Zhanga, Guodong Zhanga,b( )
Department of Food Science, University of Massachusetts-Amherst, Amherst, MA, 01003, USA
Molecular and Cellular Biology Program, University of Massachusetts-Amherst, Amherst, MA, 01003, USA

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

Human consumption of linoleic acid (LA, 18:2ω-6, abundant in vegetable oils) is very high. Animal experiments showed that excessive LA intake increased azoxymethane-induced colon tumorigenesis, however, the impact of excessive LA on colon cancer in human is not conclusive, making it difficult to make dietary recommendations for optimal intake of LA. Understanding the molecular mechanisms of LA on colon tumorigenesis could help to clarify its health effect, and facilitate development of mechanism-based strategies for preventing colon cancer. Recent studies show that the previously unappreciated cytochrome P450 monooxygenase-mediated eicosanoid pathway is upregulated in colon cancer and plays critical roles in its pathogenesis, and could contribute to the effects of dietary LA, as well as ω-3 fatty acids, on colon tumorigenesis. In this review, we will discuss recent studies about the roles of cytochrome P450 monooxygenases in fatty acid metabolism and its roles in colonic inflammation and colon cancer, and how this information could help us to clarify the health impacts of dietary fatty acids.

Keywords

Colon cancerPolyunsaturated fatty acidsCytochrome P450Linoleic acidω-3 Fatty acidsColonic inflammationEicosanoids

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Food Science and Human Wellness
Volume 8 Issue 4,
December 2019
Pages 337-343
DOI: 10.1016/j.fshw.2019.11.002
Cite this article:
Wang W, Zhang J, Zhang G. Cytochrome P450 monooxygenase-mediated eicosanoid pathway: A potential mechanistic linkage between dietary fatty acid consumption and colon cancer risk. Food Science and Human Wellness, 2019, 8(4): 337-343. https://doi.org/10.1016/j.fshw.2019.11.002

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Received: 12 September 2019
Revised: 01 November 2019
Accepted: 07 November 2019
Published: 14 November 2019
© 2019 “Society information”.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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