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Research Article | Open Access

Wolfberry extracts inhibit Aβ1-42 aggregation and rescue memory loss of AD drosophila

Cai-Hong Lia,b, Jun-Li Yanga( )
CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences (CAS), Lanzhou 730000, PR China
University of Chinese Academy of Sciences, CAS, Beijing 100049, PR China

Peer review under responsibility of KeAi Communications Co., Ltd

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Abstract

This study is to investigate the potential of wolfberry water extracts for the treatment of Alzheimer’s disease (AD) and the relationship between their anti-AD property and the geographic locations in China. Total extracts of all wolfberry samples showed the potent to decrease self-induced Aβ1-42 aggregation and Cu2+-induced Aβ1-42 aggregation and the antioxidant capacity as well as the bioactivity for binding bio-metal. A transgenic drosophila model assay revealed that TE of S1 and S6 (S1-TE and S6-TE) at 100μg/mL demonstrated the potent rescue effect on memory loss compared to the positive control memantine at 20μg/mL. Further study also revealed the polysaccharide extracts could contribute to their anti-AD property, and the anti-AD activity conspicuously depends on growing environment. Wolfberry samples S1 and S6 showed much more potent anti-AD property. Meanwhile this study demonstrated that the Chinese commonly consumed wolfberry in boiling water might have the beneficial function to prevent AD pathology.

Keywords

Aβ1−42Antioxidant bioactivityAnti-AD potentialBio-metalDrosophilaWolfberry

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Food Science and Human Wellness
Volume 9 Issue 1,
March 2020
Pages 64-70
DOI: 10.1016/j.fshw.2019.12.007
Cite this article:
Li C-H, Yang J-L. Wolfberry extracts inhibit Aβ1-42 aggregation and rescue memory loss of AD drosophila. Food Science and Human Wellness, 2020, 9(1): 64-70. https://doi.org/10.1016/j.fshw.2019.12.007

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Received: 08 August 2019
Revised: 13 November 2019
Accepted: 20 December 2019
Published: 27 December 2019
© 2020 "Society information".

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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