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Research Article | Open Access

Ganoderma lucidum spore oil (GLSO), a novel antioxidant, extends the average life span in Drosophila melanogaster

Yi Zhanga,b,c, Hongfei Caic, Zhu Taoc, Cheng Yuanc, Zhaojian Jiangc, Juyan Liub,c,d( ), Hiroshi Kuriharaa,e( ), Wendong Xub,c( )
Institute of Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, China
Postdoctoral Research Station of Guangzhou Pharmaceutical Holdings Limited, Guangdong 510130, China
Institute of National Engineering Research Center for Modernization of Extraction and Separation Process of Traditional Chinese Medicine, Hanfang Pharmaceutical Co., Ltd, Guangdong 510240, China
Guangzhou Pharmaceutical Holdings Ltd, Guangdong 510130, China
Institute of Traditional Chinese Medicine and Natural Products, Jinan University, 601, Huangpu Avenue West, Guangzhou, 510632, China

Peer review under responsibility of KeAi Communications Co., Ltd

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Abstract

In ancient China, Ganoderma lucidum was believed to be a medical fungus that could increase lifespan. Recently, pharmacologic studies have found that polysaccharide peptides and triterpenoids extracted from Ganoderma lucidum have various physiological effects as active compounds. However, the effects of spore oil isolated from Ganoderma lucidum remains unknown. In this study, the biological effects of Ganoderma lucidum spore oil (GLSO) were evaluated using a Drosophila melanogaster model. Compared with untreated groups, groups treated with GLSO had significantly longer average and maximum lifespan in both normal conditions and under oxidative stress. The activities of various antioxidant enzymes were measured to determine the antioxidant effect of GLSO. GLSO treatment markedly enhanced total superoxide dismutase (SOD) and catalase (CAT) activity and decreased levels of malondialdehyde (MDA). Further, we found dose-dependent increases in the mRNA expression of Cu, Zn-SOD, Mn-SOD, and CAT in GLSO-treated groups. These results suggest that GLSO may effectively eliminate free radicals and extend lifespan in Drosophila. Future work should investigate the value of GLSO as a functional food for the prevention of aging in larger animal models.

Keywords

Antioxidant activityDrosophila melanogasterGanoderma lucidum spore oilAnti-aging

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Food Science and Human Wellness
Volume 10 Issue 1,
January 2021
Pages 38-44
DOI: 10.1016/j.fshw.2020.05.011
Cite this article:
Zhang Y, Cai H, Tao Z, et al. Ganoderma lucidum spore oil (GLSO), a novel antioxidant, extends the average life span in Drosophila melanogaster. Food Science and Human Wellness, 2021, 10(1): 38-44. https://doi.org/10.1016/j.fshw.2020.05.011

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Received: 28 November 2019
Revised: 04 April 2020
Accepted: 21 May 2020
Published: 13 June 2020
© 2021 Beijing Academy of Food Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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