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Research Article

Chrysoeriol ameliorates hyperglycemia by regulating the carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats

Baskaran Krishnana, Abirami Ramu Ganesanb, Ravindran Balasubramanic, Dinh Duc Nguyenc, Soon Woong Changc, Shaoyun Wangd, Jianbo Xiaoe( ), Balamuralikrishnan Balasubramanianf( )
Department of Biochemistry, Sree Narayana Guru College, Coimbatore, 641105, Tamil Nadu, India
Department of Food Science and Home Economics, School of Applied Sciences, College of Engineering, Science and Technology, Fiji National University, Fiji Islands
Department of Environmental Energy and Engineering, Kyonggi University, Youngtong-Gu, Suwon, Gyeonggi-Do, 16227, South Korea
College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China
International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China
Department of Food Science and Biotechnology, College of Life Sciences, Sejong University, Seoul, 05006, South Korea

Peer review under responsibility of KeAi Communications Co., Ltd

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Abstract

The present study aimed to evaluate the effects of chrysoeriol from Cardiospermum halicacabum in streptozotocin induced Wistar rats. Thirty rats were categorized as control, diabetic control supplemented with 0, 20 mg/kg chrysoeriol and 600 μg/kg BW of glibenclamide for 45-day trial period. Our results indicated that the inclusion of chrysoeriol (20 mg/kg), showed a significant reduction in plasma glucose, hemoglobin and glycosylated hemoglobin level with a rising of plasma insulin sensitivity. Further, downregulated enzymes including glucose 6-phosphatase, fructose 1,6-bisphosphatase, and glycogen phosphorylase as well upregulated enzymes such as hexokinase, glucose-6-phosphate dehydrogenase, pyruvate kinase, and hepatic glycogen content. There was a diminish action found in liver glycogen synthase of tested rat with a rise in gamma-glutamyl transpeptidase, towards normal levels upon treatment with chrysoeriol. The histopathological study confirmed that renewal of the beta cells of pancreatic of chrysoeriol and glibenclamide treated rats. In addition, the molecular docking of chrysoeriol against glycolytic enzymes including hexokinase, glucose-6-phosphate dehydrogenase, pyruvate kinase, using Argus software shows chrysoeriol had greatest ligand binding energy as equivalent to glibenclamide, as a standard drug. Thus, chrysoeriol found to be non-toxic with potential regulation on glycemic control and upregulation of the carbohydrate metabolic enzymes.

Keywords

Cardiospermum halicacabumChrysoeriolAnti-hyperglycemicCarbohydrate metabolizing enzymes

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Food Science and Human Wellness
Volume 9 Issue 4,
December 2020
Pages 346-354
DOI: 10.1016/j.fshw.2020.05.014
Cite this article:
Krishnan B, Ramu Ganesan A, Balasubramani R, et al. Chrysoeriol ameliorates hyperglycemia by regulating the carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats. Food Science and Human Wellness, 2020, 9(4): 346-354. https://doi.org/10.1016/j.fshw.2020.05.014

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Received: 27 February 2020
Revised: 15 May 2020
Accepted: 29 May 2020
Published: 06 June 2020
© 2020 Beijing Academy of Food Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
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