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Research Article | Open Access

Auricularia polytricha noodles prevent hyperlipemia and modulate gut microbiota in high-fat diet fed mice

Donglu Fanga, Dan Wangb, Gaoxing Mab, Yang Jia, Huihua Zhenga,c, Hui Chena,c, Mingwen Zhaod, Qiuhui Hua, Liyan Zhaoa( )
College of Food Science and Technology, Nanjing Agricultural University/Key Laboratory of Edible Mushroom Processing, Ministry of Agriculture and Rural Affairs, Nanjing 210095, China
College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing 210023, China
Jiangsu Alphay Bio-technology Co., Ltd., Nantong 226009, China
College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China

Peer review under responsibility of KeAi Communications Co., Ltd

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Abstract

Auricularia polytricha possesses hypolipidemic effects and decreases lipid accumulation, leading to potential food additives for functional food processing. In this research, we explored the potential effects of A. polytricha noodles on hyperlipidemia and gut microbiota dysbiosis, and elucidated their possible regulatory mechanisms on lipid metabolism in high-fat diet (HFD) mice. A. polytricha noodles treatment significantly (< 0.05) reduced body weight gain, hyperlipidemia and liver fat accumulation. Meanwhile, A. polytricha noodles decreased the levels of serum total cholesterol (TC), total triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) compared with the HFD group. Furthermore, A. polytricha noodles could enrich the diversity of gut microbiota by decreasing the ratio of Firmicutes to Bacteroidetes as well as the relative abundance of Deferribacteres and increased the relative abundance of Verrucomicrobia, which might contribute to the prevention of hyperlipidemia. This study indicated that A. polytricha noodles could modulate the gut microbiota and prevent hyperlipidemia and liver fat accumulation induced by HFD.

Keywords

Gut microbiotaLipid metabolismAuricularia polytricha noodlesHyperlipidemia

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Food Science and Human Wellness
Volume 10 Issue 4,
July 2021
Pages 431-441
DOI: 10.1016/j.fshw.2021.04.005
Cite this article:
Fang D, Wang D, Ma G, et al. Auricularia polytricha noodles prevent hyperlipemia and modulate gut microbiota in high-fat diet fed mice. Food Science and Human Wellness, 2021, 10(4): 431-441. https://doi.org/10.1016/j.fshw.2021.04.005

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Received: 05 October 2020
Revised: 29 October 2020
Accepted: 03 November 2020
Published: 04 June 2021
© 2021 Beijing Academy of Food Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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