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Research Article | Open Access

Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice

Li Suna,b,#, Li Baoc,#, Dorji Phurbud,#, Shanshan Qiaoa,b, Shanshan Suna,e, Yangzom Permad, Hongwei Liua,b( )
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100864, China
Savaid Medicine School, University of Chinese Academy of Sciences, Beijing 100864, China
Beijing Shijitan Hospital, Capital Medicinal University, Beijing 100864, China
Tibet Plateau Institute of Biology, Lhasa 850000, China
School of Life Sciences, University of Science and Technology of China, Hefei 230026, China

# These authors contributed equally.

Peer review under responsibility of KeAi Communications Co., Ltd

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Abstract

A polyphenolic alkaloid-enriched extract (PAE) was prepared from the fruiting bodies of a wild edible mushroom Sarcodon leucopus. Oral administration of PAE reduced hyperglycemia, hyperlipidemia, hepatic steatosis, and LPS-related inflammation in high fat diet-induced obese (DIO) mice. Furthermore, we show that PAE produces taxonomic and predicted functional changes in the gut microbiome of DIO mice. A significant decrease in the family of Ruminococcaceae, especially the secondary bile acid-producing bacteria of Intestinimonas and Anaerotruncus, is detected in the gut microbiome of PAE-treate mice. Accordingly, reductions of deoxycholic acid and lithocholic acid are found in the feces of PAE-treated DIO mice, which benefits for the intestinal integrity and the reduction of inflammation. A gut microbiota related mechanism for the anti-metabolic syndrome effects of the PAE is proposed. We suppose the polyphenolic alkaloid extract from S. leucopus be a new and beneficial prebiotic regulating glucose and lipid metabolisms.

Keywords

Gut microbiotaMetabolic syndromeSarcodon leucopusPolyphenolic alkaloidsRuminococcaceae

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Food Science and Human Wellness
Volume 10 Issue 4,
July 2021
Pages 442-451
DOI: 10.1016/j.fshw.2021.04.006
Cite this article:
Sun L, Bao L, Phurbu D, et al. Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice. Food Science and Human Wellness, 2021, 10(4): 442-451. https://doi.org/10.1016/j.fshw.2021.04.006

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Received: 14 April 2020
Revised: 20 May 2020
Accepted: 12 July 2020
Published: 04 June 2021
© 2021 Beijing Academy of Food Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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