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Research Article | Open Access

The triterpenoids-enriched extracts from Antrodia cinnamomea mycelia attenuate alcohol-induced chronic liver injury via suppression lipid accumulation in C57BL/6 mice

Yange Liua,b, Ronglong Chena, Lanzhou Lib, Ruitao Dongb, Hui Yinc, Yawen Wanga, Anhui Yangb, Jianbin Wanga, Changtian Lid( ), Di Wangb,d( )
School of Basic Medical Sciences, Nanchang University, Nanchang 330038, China
School of Life Sciences, Jilin University, Changchun 130012, China
Department of Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun 130118, China

Peer review under responsibility of KeAi Communications Co., Ltd

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Abstract

The major pathologic hallmark of the alcoholic liver disease (ALD) is the representation of chronic alcohol-induced hepatocyte lipid accumulation. This study aims to investigate the hepatoprotective role of triterpenoids-enriched extracts from Antrodia cinnamomea mycelia (ACT) in chronic alcohol-induced liver injury mice, establishing in C57BL/6 mice through gradient alcohol feeding for 24 weeks. In long-term alcohol consumption mice, the significantly lost body weight, increased organ indexes, hepatic alanine aminotransferase and aspartate aminotransferase levels were all remissed after 6-week ACT orally administration, showing its hepatoprotective property. ACT suppressed the triglyceride, total cholesterol and low-density lipoprotein levels, and enhanced high-density lipoprotein levels in serum or/and liver of chronic alcohol damaged mice. Combining with the pathological observations, ACT displayed an anti-steatosis effects to restrain the progress of ALD. Based on proteomic analysis and enzyme-linked immunosorbent assay, ACT had been confirmed to regulate the levels of lipid biogeneration-related factors and depressed the over-accumulation of hepatic reactive oxygen species. According to further data, ACT prevented alcoholic liver injury may be associated with mediating lipid metabolism-related to PGC-1α and NF-κB signaling. In summary, ACT protected the body against chronic alcohol ingest induced liver injury through its regulation lipid on metabolism.

Keywords

Antrodia cinnamomea myceliaTriterpenoidsChronic alcohol-induced liver injuryLipid accumulation

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Food Science and Human Wellness
Volume 10 Issue 4,
July 2021
Pages 497-507
DOI: 10.1016/j.fshw.2021.04.012
Cite this article:
Liu Y, Chen R, Li L, et al. The triterpenoids-enriched extracts from Antrodia cinnamomea mycelia attenuate alcohol-induced chronic liver injury via suppression lipid accumulation in C57BL/6 mice. Food Science and Human Wellness, 2021, 10(4): 497-507. https://doi.org/10.1016/j.fshw.2021.04.012

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Received: 30 August 2020
Revised: 29 September 2020
Accepted: 30 September 2020
Published: 04 June 2021
© 2021 Beijing Academy of Food Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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