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Research Article | Open Access

Antioxidant and hepatoprotective effects of Hypsizygus ulmarius polysaccharide on alcoholic liver injury in rats

Sudha Govindana( ), Angu Jayabalb, Jayasakthi Shanmugamb, Prasanna Ramanic,d
Department of Biochemistry, School of Biosciences, Periyar University, Salem, India
Department of Biochemistry, Kongunadu Arts and Science College, Bharathiar University, Coimbatore, India
Dhanvanthri Lab, Department of Sciences, Amrita School of Engineering, Coimbatore, Amrita Vishwa Vidyapeetham, India
Center of Excellence in Advanced Materials & Green Technologies (CoE–AMGT), Amrita School of Engineering, Coimbatore, Amrita Vishwa Vidyapeetham, India

Peer review under responsibility of KeAi Communications Co., Ltd

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Abstract

Hypsizygus ulmarius polysaccharide (HUP) is a water-soluble polysaccharide obtained by hot water extraction, followed by precipitation and deproteinization. The characteristics of HUP, antioxidant activity and liver protection against alcohol-induced liver damage were studied. Structural characteristics indicate that the HUP is a pyran-type polysaccharide with a molecular weight of 2076Da. In antioxidant scavenging assay, HUP showed moderate DMPD radical scavenging activity, cupric ion reducing antioxidant capacity and inhibitory effect against lipid peroxidation in a dose-dependent manner. Regarding in vivo hepatoprotective activity, compared with the ethanol induction group, pre-treatment of low and high doses of HUP significantly reduced the behaviours of serum enzymes, lowered the levels of hepatic oxidative stress markers, restored the levels of biochemical constituents, enhanced the levels of liver and serum enzymatic antioxidants and non-enzymatic antioxidants, and improved the serum lipid levels of alcohol-intoxicated rats. The hepatoprotective effect of HUP was comparable to positive control silymarin. Besides, HUP pre-treatment significantly normalized the histopathological changes induced by ethanol. The results indicate that HUP could be used as a functional food and may protect the biological system from oxidative stress through its antioxidant activity, thus having a significant protective effect on acute alcoholic liver injury.

Keywords

Antioxidant activityLiver damageHypsizygus ulmarius polysaccharideHepatoprotective behaviourEthanol consumption

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Food Science and Human Wellness
Volume 10 Issue 4,
July 2021
Pages 523-535
DOI: 10.1016/j.fshw.2021.04.015
Cite this article:
Govindan S, Jayabal A, Shanmugam J, et al. Antioxidant and hepatoprotective effects of Hypsizygus ulmarius polysaccharide on alcoholic liver injury in rats. Food Science and Human Wellness, 2021, 10(4): 523-535. https://doi.org/10.1016/j.fshw.2021.04.015

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Received: 15 October 2020
Revised: 15 January 2021
Accepted: 17 January 2021
Published: 04 June 2021
© 2021 Beijing Academy of Food Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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